m-PEG5-succinimidyl carbonate Chemical Properties

Boiling point:

469.3±55.0 °C(Predicted)

Density 

1.25±0.1 g/cm3(Predicted)

form 

Liquid

color 

Colorless to light yellow

m-PEG5-succinimidyl carbonate Usage And Synthesis

Description

m-PEG5-succinimidyl carbonate is a PEG linker with an attached succinumidyl carbonate group. The succinimidyl carbonate group is a good leaving group and commonly reacts with amine nucleophiles.

Uses

m-PEG5-succinimidyl carbonate is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG5-succinimidyl carbonate is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

IC 50

PEGs; Alkyl/ether; Non-cleavable Linker

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005