Piperidine, 4-[[3-(1,3-benzodioxol-5-yl)-1,2,4-oxadiazol-5-yl]methyl]-1-cyclobutyl-
Piperidine, 4-[[3-(1,3-benzodioxol-5-yl)-1,2,4-oxadiazol-5-yl]methyl]-1-cyclobutyl- Basic information
- Product Name:
- Piperidine, 4-[[3-(1,3-benzodioxol-5-yl)-1,2,4-oxadiazol-5-yl]methyl]-1-cyclobutyl-
- Synonyms:
-
- Piperidine, 4-[[3-(1,3-benzodioxol-5-yl)-1,2,4-oxadiazol-5-yl]methyl]-1-cyclobutyl-
- 3-(Benzo[d][1,3]dioxol-5-yl)-5-((1-cyclobutylpiperidin-4-yl)methyl)-1,2,4-oxadiazole
- H3R antagonist 1
- CAS:
- 1448422-61-4
- MF:
- C19H23N3O3
- MW:
- 341.4
- Mol File:
- 1448422-61-4.mol
Piperidine, 4-[[3-(1,3-benzodioxol-5-yl)-1,2,4-oxadiazol-5-yl]methyl]-1-cyclobutyl- Chemical Properties
- Boiling point:
- 490.8±55.0 °C(Predicted)
- Density
- 1.282±0.06 g/cm3(Predicted)
- pka
- 9.53±0.40(Predicted)
- form
- Solid
- color
- White to off-white
Piperidine, 4-[[3-(1,3-benzodioxol-5-yl)-1,2,4-oxadiazol-5-yl]methyl]-1-cyclobutyl- Usage And Synthesis
Uses
H3R-IN-1 is a histamine receptor 3 (H3R) inverse agonist extracted from patent WO2013107336A1, compound example 2.
in vivo
The ability of H3R-IN-1 to enhance in vivo remyelination is determined with the Cuprizone/Rapamycin-induced demyelination model. Mice are treated with Cuprizone diet combined with intraperitoneal injections of Rapamycin for 5 weeks followed by 9 days of compound administration. Cuprizone diet plus intraperitoneal injections of Rapamycin induced severe demyelination in both corpus callosum and cortex and treatment with H3R-IN-1 (30 mg/kg, 9 days) significantly increases density of myelin specific Black-gold II staining in the lesion of corpus callosum and cortex in forebrain, compared to vehicle control group[1].
References
[1] WANG, Rong, et al. THERAPEUTIC USES. WO2013107336A1.
Piperidine, 4-[[3-(1,3-benzodioxol-5-yl)-1,2,4-oxadiazol-5-yl]methyl]-1-cyclobutyl-Supplier
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