DM3 Chemical Properties

Boiling point:

942.2±65.0 °C(Predicted)

Density 

1.30±0.1 g/cm3(Predicted)

pka

9.82±0.70(Predicted)

form 

Solid

color 

White to off-white

DM3 Usage And Synthesis

Uses

DM3 (Maytansinoid DM3), a Maytansine (HY-13674) analog bearing disulfide or thiol groups, and is a tubulin inhibitor. DM3 a cytotoxic moiety of antibody-drug conjugates (ADCs)[1][2].

IC 50

Maytansinoids

References

[1] Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8). DOI:10.3390/molecules22081281
[2] Griffin P, et al. High anti-tumor activity of a novel alpha-fetoprotein-maytansinoid conjugate targeting alpha-fetoprotein receptors in colorectal cancer xenograft model. Cancer Cell Int. 2023 Apr 5;23(1):60. DOI:10.1186/s12935-023-02910-0