3-[(2-CHLOROBENZYL)SULFANYL]-1H-1,2,4-TRIAZOL-5-YLAMINE Chemical Properties

Melting point:

142-144°C

Boiling point:

488.6±47.0 °C(Predicted)

Density 

1.49±0.1 g/cm3(Predicted)

storage temp. 

4°C, protect from light

solubility 

DMSO : 100 mg/mL (415.44 mM; Need ultrasonic)

pka

9.73±0.40(Predicted)

form 

Solid

color 

White to off-white

Safety Information

HazardClass 

IRRITANT

3-[(2-CHLOROBENZYL)SULFANYL]-1H-1,2,4-TRIAZOL-5-YLAMINE Usage And Synthesis

Uses

Antibacterial agent 117, triazole derivative, is an antibacterial agent. Antibacterial agent 117 has against R. prowazekii MetAP1 (RpMetAP1) activity with an IC50 value of 15 μM. Antibacterial agent 117 also inhibits rickettsial growth and can be used for the research of infection[1].

References

[1] Travis R Helgren, et al. Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents. Bioorg Med Chem DOI:10.1016/j.bmc.2016.11.013