KR-62436
KR-62436 Basic information
- Product Name:
- KR-62436
- Synonyms:
-
- 6-{2-[(5-Cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile dihydrochloride hydrate
- KR-62436 hydrate
- 3-Pyridinecarbonitrile, 6-[[2-[[2-(5-cyano-4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethyl]amino]ethyl]amino]-
- CAS:
- 761414-79-3
- MF:
- C14H15N7O
- MW:
- 297.32
- Mol File:
- 761414-79-3.mol
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KR-62436 Chemical Properties
- storage temp.
- 2-8°C
- solubility
- H2O: 12 mg/mL
- form
- powder
- color
- white to beige
- Water Solubility
- H2O: 5mg/mL, clear
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KR-62436 Usage And Synthesis
Biochem/physiol Actions
KR-62436 is a competitive inhibitor of dipeptidyl peptidase-IV (DPP-IV). DPP-IV is a serine protease which inactivates glucagon-like peptide (GLP-1); IC50 0.1-0.8 μM; GLP-1 is a potent stimulus for insulin secretion and inducer of satiety after food intake, but it has a very short action (1 min) because it is rapidly degraded by DPP-IV; blocking DPP-IV increases GLP-1 action and increases plasma insulin levels; DPP-IV inhibitors and KR-62436 have clinical potential as anti-diabetic agents