(ISOCYANOIMINO)TRIPHENYLPHOSPHORANE Chemical Properties

Melting point:

160-161 °C

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

solid

color 

White to Light yellow to Light orange

Safety Information

HS Code 

29319090

(ISOCYANOIMINO)TRIPHENYLPHOSPHORANE Usage And Synthesis

Uses

Despite growing interest for therapeutic and other biological applications, cyclic peptidomimetics are challenging to synthesize. As reported by the lab of Andrei Yudin, (N-isocyanoimino)triphenylphosphorane (Pinc
) enables zwitterionic-controlled generation of peptide macrocyles from linear peptides and aldehydes. Containing a 1,3,4-oxadiazole, the resulting peptide exhibits both improved membrane permeability, lipophilicity, and aqueous solubility.
Different functional groups can be introduced by varying the aldehyde, and initial work used propionaldehyde (538124), phenylacetaldehyde (107395), and isovaleraldehyde (146455).

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