MOLINDONE HYDROCHLORIDE (500 MG) Chemical Properties

Melting point:

211-213°C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

H2O: soluble19mg/mL

form 

solid

color 

off-white

Merck 

14,6233

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

NM3325000

HazardClass 

6.1

PackingGroup 

III

HS Code 

2934990002

Toxicity

LD50 orally in rats: 261 mg/kg (Goldenthal)

MOLINDONE HYDROCHLORIDE (500 MG) Usage And Synthesis

Chemical Properties

Light Tan Solid

Originator

Moban,Endo,US,1974

Uses

Antipsychotic;Dopamine receptor antagonist

Uses

D2 Dopamine receptor antagonist. MAO inhibitor. Antipsychotic.

Definition

ChEBI: Molindone hydrochloride is a member of indoles.

Manufacturing Process

Diethyl ketone may be reacted with methyl nitrite and that product in turn reacted with cyclohexan-1,3-dione to give 3-ethyl-4,5,6,7-tetrahydro-2- methyl-4-oxoindole.
3-ethyl-4,5,6,7-tetrahydro-2-methyl-4-oxoindole 14.1 g (0.08 mol), 14.8 g morpholine hydrochloride (0.12 mol), and 3.6 g paraformaldehyde (0.12 mol) were refluxed in 200 ml ethanol for 40 hours. The solution was evaporated to dryness in vacuo on a steam bath and the residue digested with a mixture of 150 ml water and 10 ml 2N HCl. An insoluble residue of unreacted starting material was filtered off. To the acid solution, ammonia water was added dropwise with stirring and the amine crystallized out. It was purified by dissolving in 1N HCl and addition of ammonia, then by 2 crystallizations from benzene followed by 2 crystallizations from isopropanol, to yield 3-ethyl- 4,5,6,7-tetrahydro-2-methyl-4-oxoindole, melting point 180°C to 181°C.

brand name

Moban (Endo).

Therapeutic Function

Antipsychotic

MOLINDONE HYDROCHLORIDE (500 MG)(15622-65-8)Related Product Information

• Ethylamine
• (-)-Varitriol
• MOLINDONE HYDROCHLORIDE (500 MG)
• 3-ethyl-2-methyl-4,5,6,7-tetrahydroindol-4-one
• 3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one