RU 28362
RU 28362 Basic information
- Product Name:
- RU 28362
- Synonyms:
-
- 11,17-dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one
- (11β,17β)-11,17-Dihydroxy-6-methyl-17-(1-propynyl)-androsta-1,4,6-trien-3-one
- 11β,17β-Dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-trien-3-one
- Androsta-1,4,6-trien-3-one, 11,17-dihydroxy-6-methyl-17-(1-propynyl)-, (11β,17β)-
- CAS:
- 74915-64-3
- MF:
- C23H28O3
- MW:
- 352.47
- Mol File:
- 74915-64-3.mol
RU 28362 Chemical Properties
- Boiling point:
- 533.2±50.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 33 mg/mL, soluble
- form
- solid
- pka
- 12.82±0.70(Predicted)
RU 28362 Usage And Synthesis
Uses
RU28362 is a potent and selective glucocorticoid agonist. RU28362 increases the Bnip3 mRNA levels in neurons. RU28362 inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion[1][2]. RU28362 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
in vivo
RU28362 (150 μg/kg; i.p.) inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion and selectively suppressed the stress-induced increase in POMC hnRNA in the anterior pituitary gland[2].
| Animal Model: | 250-350 g, adult male Sprague-Dawley rats[2] |
| Dosage: | 150 μg/kg |
| Administration: | I.p.; 60 min before exposure to a 15-min period of restraint stress |
| Result: | Inhibited adrenocorticotrophic hormone (ACTH) and corticosterone secretion and selectively suppressed the stress-induced increase in POMC hnRNA in the anterior pituitary gland. |
References
[1] Sandau US, et al. Glucocorticoids exacerbate hypoxia-induced expression of the pro-apoptotic gene Bnip3 in the developing cortex. Neuroscience. 2007 Jan 19;144(2):482-94. DOI:10.1016/j.neuroscience.2006.10.003
[2] Ginsberg AB, et al. Specific and time-dependent effects of glucocorticoid receptor agonist RU28362 on stress-induced pro-opiomelanocortin hnRNA, c-fos mRNA and zif268 mRNA in the pituitary. J Neuroendocrinol. 2006 Feb;18(2):129-38. DOI:10.1111/j.1365-2826.2005.01396.x
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