Basic information Safety Supplier Related

DIGALLIC ACID

Basic information Safety Supplier Related

DIGALLIC ACID Basic information

Product Name:
DIGALLIC ACID
Synonyms:
  • Digallic acid - mixture of para and meta digallic acid
  • 3,4-dihydroxy-5-((3,4,5-trihydroxybenzoyl)oxy)-benzoicaci
  • 3,4-dihydroxy-5-((3,4,5-trihydroxybenzoyl)oxy)benzoicacid
  • 3-galloylgallicacid
  • gallicacid,3-gallate
  • 3-O-Galloylgallic acid
  • 5-Galloyloxyprotocatechuic acid
  • Digallate
CAS:
536-08-3
MF:
C14H10O9
MW:
322.22
EINECS:
2086247
Product Categories:
  • Aromatics Compounds
  • Aromatics
Mol File:
536-08-3.mol
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DIGALLIC ACID Chemical Properties

Melting point:
267-269°C
Boiling point:
420.86°C (rough estimate)
Density 
1.5467 (rough estimate)
refractive index 
1.7770 (estimate)
storage temp. 
-20°C Freezer
solubility 
DMSO: Soluble; Methanol: Soluble
form 
A solid
pka
4.11±0.10(Predicted)
Water Solubility 
0.5g/L(25 ºC)
Stability:
Hygroscopic
LogP
1.970 (est)
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DIGALLIC ACID Usage And Synthesis

Description

Digallic acid is a natural polyphenolic that can be produced by hydrolysis of gallotannins. Like other polyphenolic compounds, digallic acid has antioxidant activity that can be cytoprotective. Digallic acid inhibits reverse transcriptases from human immunodeficiency virus (Ki = 0.58 μM) and murine leukemia virus. It also inhibits calcium-activated chloride channels, blocking the initial agonist-stimulated chloride current.

Chemical Properties

Off-White Solid

Uses

Digallic Acid is an intermolecular ester of Gallic acid (G188900), a phenolic acid with antioxidant activity. Gallic acid was found to protect human cells against oxidative damage and showed cytotoxicity against cancer cells. Gallic Acid and its esters also show antiviral and antifungal activities.

Definition

ChEBI: Digallic acid is a benzoate ester and a gallate ester. It is functionally related to a gallic acid. It is a conjugate acid of a digallate.

References

[1] WISSEM BHOURI . Study of genotoxic, antigenotoxic and antioxidant activities of the digallic acid isolated from Pistacia lentiscus fruits[J]. Toxicology in Vitro, 2010, 24 2: Pages 509-515. DOI: 10.1016/j.tiv.2009.06.024
[2] HIDEO NAKANE  Katsuhiko O  Masanori Fukushima. Differential Inhibition of Reverse Transcriptase and Various DNA Polymerases by Digallic Acid and Its Derivatives[J]. Journal of Natural Products , 1990, 53 5: 1234-1240. DOI: 10.1021/np50071a015
[3] WAN NAMKUNG  A S V  Puay Wah Phuan. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells.[J]. The Journal of Biological Chemistry, 2011: 2365-2374. DOI: 10.1074/jbc.m110.175109

DIGALLIC ACIDSupplier

J & K SCIENTIFIC LTD.
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200 18116577057
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3003855609@qq.com
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DIGALLIC ACID(536-08-3)Related Product Information