4-Bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Chemical Properties

Boiling point:

565.4±45.0 °C(Predicted)

Density 

1.794±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

pka

10+-.0.40(Predicted)

form 

Solid

color 

Off-white to gray

InChI

InChI=1S/C13H9BrN2O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5H2,(H,15,17,18)

InChIKey

NUICQRZENMKDBW-UHFFFAOYSA-N

SMILES

C1(=O)C2=C(C(Br)=CC=C2)C(=O)N1C1CCC(=O)NC1=O

4-Bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Usage And Synthesis

Description

4-Bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione is a thalidomide analog that can be useful in PROTAC research.

Uses

Thalidomide-4-Br (compound 53) is a compound with a bromodomain. Thalidomide-4-Br can be used in the research of inflammation, tumor and neurology[1].

References

[1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816