Almorexant-13C-d3 Chemical Properties

solubility 

DMF: soluble
DMSO: soluble
Methanol: soluble

Almorexant-13C-d3 Usage And Synthesis

Uses

Almorexant-13C-d3 is a labelled isotope of of Almorexant (A575195) . Almorexant regulates sleep and wakefulness through two G protein-coupled receptors.

References

[1] PARI MALHERBE. Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison with selective OX1 and OX2 antagonists.[J]. Molecular Pharmacology, 2009, 76 3: 618-631. DOI: 10.1124/mol.109.055152
[2] CATHERINE BRISBARE-ROCH. Promotion of sleep by targeting the orexin system in rats, dogs and humans[J]. Nature Medicine, 2007, 13 2: 150-155. DOI: 10.1038/nm1544
[3] HENDRIK DIETRICH  François J. Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant.[J]. Psychopharmacology, 2010, 212 2: 145-154. DOI: 10.1007/s00213-010-1933-5

Almorexant-13C-d3(2738376-75-3)Related Product Information

• NA
• (R)-2-((R)-6,7-dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide
• Almorexant (αS,1S) Isomer
• Almorexant-d6