E[c(RGDfK)]c(RGDfK) Chemical Properties

Density 

1.51±0.1 g/cm3(Predicted)

pka

3.70±0.10(Predicted)

form 

Solid

color 

White to off-white

Sequence

Glu[cyclo(Arg-Gly-Asp-{d-Phe}-Lys)]-cyclo(Arg-Gly-Asp-{d-Phe}-Lys)

InChIKey

HBRYUNRKUGWZGH-LXHRPZKENA-N

E[c(RGDfK)]c(RGDfK) Usage And Synthesis

Uses

E(c(RGDfK)) is an αvβ3 integrin-specific binding moiety with tumor targeting properties. Increased uptake of E(c(RGDfK)) in human ovarian cancer OVCAR-3 xenograft tumors may be useful in cancer research[1].

References

[1] Polyak D, et al. Development of PEGylated doxorubicin‐E‐[c (RGDfK) 2] conjugate for integrin‐targeted cancer therapy[J]. Polymers for Advanced Technologies, 2011, 22(1): 103-113.