2,6-DIMETHYLPHENYLPROPIONATE Chemical Properties

Boiling point:

78-80°C under H.V.

storage temp. 

Refrigerator, under inert atmosphere

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Oil

color 

Colourless

2,6-DIMETHYLPHENYLPROPIONATE Usage And Synthesis

Chemical Properties

Colourless Oil

Uses

2,6-Dimethylphenylpropionate is used as an intermediate in the Saliniketal A, B formal synthesis desymmetrization.

Preparation

2,6-Dimethylphenyl Propionate is prepared in excellent yield by the reaction of the sodium or lithium salt of 2,6-dimethylphenol with propionyl chloride.^[1a,1b]

General Description

2,6-Dimethylphenyl Propionate is a lithium, titanium, and zirconium enolates used in the stereoselective synthesis of anti or syn β-hydroxy acid derivatives.

References

1. (a) Montgomery, S. H.; Pirrung, M. C.; Heathcock, C. H. OS 1985, 63, 99; OSC 1990, 7, 190. (b) Heathcock, C. H.; Pirrung, M. C.; Montgomery, S. H.; Lampe, J. T 1981, 37, 4087