Basic information Safety Supplier Related

9-L-Leucine-1-9-kallidin

Basic information Safety Supplier Related

9-L-Leucine-1-9-kallidin Basic information

Product Name:
9-L-Leucine-1-9-kallidin
Synonyms:
  • (DES-ARG10,LEU9)-KALLIDIN
  • H-LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-LEU-OH
  • LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-LEU
  • LYS-(DES-ARG9,LEU8)-BRADYKININ
  • [LYS0, DES-ARG9, LEU8]BRADYKININ
  • Lys-(des-Arg9, Leu8)-Bradykinin trifluoroacetate salt
  • LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-LEU: KRPPGFSPL
  • Lys-(Des-Arg9,Leu8)-Bradykinin (Des-Arg10,Leu9)-Kallidin
CAS:
71800-37-8
MF:
C47H75N13O11
MW:
998.2
Mol File:
71800-37-8.mol
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9-L-Leucine-1-9-kallidin Chemical Properties

Density 
1.45±0.1 g/cm3(Predicted)
storage temp. 
−20°C
form 
Solid
pka
3.71±0.21(Predicted)
color 
White to off-white
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Safety Information

WGK Germany 
3

MSDS

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9-L-Leucine-1-9-kallidin Usage And Synthesis

Description

Lys-(des-Arg9, Leu8)-Bradykinin trifluoroacetate salt is a peptide chain containing nine amino acids. The amino acid sequence of bradykinin is Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg (RPPGFSPFR). Bradykinin is a peptide that causes blood vessels to dilate, thus resulting in lower blood pressure. A class of drugs used to lower blood pressure called ACE inhibitors lower blood pressure by increasing the concentration of bradykinin (by inhibiting its degradation). Bradykinin acts on blood vessels by releasing prostacyclin, nitric oxide, and endothelial-derived hyperpolarizing factors.

Application

As one of the end effectors of the kallikrein-kinin system,Lys-(des-Arg9, Leu8)-Bradykinin trifluoroacetate salt has various biological activities, such as vasodilator, increase vascular permeability, induce contraction of non-vascular smooth muscle and so on.

Mechanism of action

Lys-(des-Arg9, Leu8)-Bradykinin trifluoroacetate salt is a potent endothelium-dependent vasodilator that causes non-vascular smooth muscle contraction, increases vascular permeability and is also involved in pain mechanisms. Bradykinin also causes an increase in urine sodium, which helps lower blood pressure.

It increases calcium levels inside neocortical astrocytes, causing them to release glutamate.

In some patients treated with angiotensin I-converting enzyme (ACE) inhibitors, bradykinin has been implicated as a cause of dry cough. This difficult-to-treat cough usually results from discontinuation of ACE inhibitor therapy. In such cases, angiotensin II receptor antagonists are used as the next step in therapy.

9-L-Leucine-1-9-kallidinSupplier

GL Biochem (Shanghai) Ltd
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21-61263452 13641803416
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ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
Email
info@hanhongsci.com
Chemsky(shanghai)International Co.,Ltd.
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021-50135380
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shchemsky@sina.com
Cellmano Biotech Limited
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0551-65326643 18156095617
Email
info@cellmano.com
Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
Email
meilunui@163.com