ETHYL 2-(3-OXO-2-PIPERAZINYL)ACETATE Chemical Properties

Melting point:

110-111°C

Boiling point:

360.6±27.0 °C(Predicted)

Density 

1.101±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

pka

15.06±0.40(Predicted)

Appearance

White to off-white Solid

InChI

InChI=1S/C8H14N2O3/c1-2-13-7(11)5-6-8(12)10-4-3-9-6/h6,9H,2-5H2,1H3,(H,10,12)

InChIKey

HNYRNJAZRKCHSC-UHFFFAOYSA-N

SMILES

N1CCNC(=O)C1CC(OCC)=O

CAS DataBase Reference

33422-35-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HazardClass 

IRRITANT

HS Code 

2933599590

ETHYL 2-(3-OXO-2-PIPERAZINYL)ACETATE Usage And Synthesis

Synthesis

1. Ethylenediamine (1.17 mL, 17.42 mmol) and diethyl maleate (3 g, 17.42 mmol) were added to a 50 mL round bottom flask and dissolved in propanol (30 mL). 2. The reaction mixture was stirred at 55 °C for 16 h. 3. Upon completion of the reaction, the solvent was removed under reduced pressure by rotary evaporator. 4. The residue was placed in a vacuum drying chamber and The residue was dried to give the crude ethyl 2-(3-oxopiperazin-2-yl)acetate. 5. The crude product was used directly in the next step of the reaction without further purification. Yield: 3.4 g (quantitative yield).

References

[1] Patent: US2008/312231, 2008, A1. Location in patent: Page/Page column 40
[2] Journal of Heterocyclic Chemistry, 1993, vol. 30, # 1, p. 275 - 276
[3] Journal of Pharmaceutical Sciences, 1990, vol. 79, # 5, p. 447 - 452

ETHYL 2-(3-OXO-2-PIPERAZINYL)ACETATE(33422-35-4)Related Product Information

• ETHYL 2-(3-OXO-2-PIPERAZINYL)ACETATE
• Ethyl acetate
• ETHYL 2-[1-(2,4-DICHLOROBENZOYL)-3-OXO-2-PIPERAZINYL]ACETATE
• ETHYL 2-(3-OXO-1-[(2,4,5-TRICHLOROPHENYL)SULFONYL]-2-PIPERAZINYL)ACETATE
• ETHYL 2-[1-(4-CHLOROBENZOYL)-3-OXO-2-PIPERAZINYL]ACETATE
• ETHYL 2-(1-BENZOYL-3-OXO-2-PIPERAZINYL)ACETATE
• ETHYL 2-[1-(2,4-DIFLUOROBENZOYL)-3-OXO-2-PIPERAZINYL]ACETATE
• ETHYL 2-(3-OXO-1-[3-(TRIFLUOROMETHYL)BENZOYL]-2-PIPERAZINYL)ACETATE
• ETHYL 2-(1-[(4-METHYLPHENYL)SULFONYL]-3-OXO-2-PIPERAZINYL)ACETATE
• ETHYL 2-[1-(4-METHYLBENZOYL)-3-OXO-2-PIPERAZINYL]ACETATE
• ETHYL 2-(1-[(3,4-DICHLOROPHENYL)SULFONYL]-3-OXO-2-PIPERAZINYL)ACETATE
• ETHYL 2-(1-[(4-METHOXYPHENYL)SULFONYL]-3-OXO-2-PIPERAZINYL)ACETATE
• ETHYL 2-[3-OXO-1-(PHENYLSULFONYL)-2-PIPERAZINYL]ACETATE
• ETHYL 2-[1-(3,4-DICHLOROBENZOYL)-3-OXO-2-PIPERAZINYL]ACETATE
• ETHYL 2-(1-[(4-BROMOPHENYL)SULFONYL]-3-OXO-2-PIPERAZINYL)ACETATE
• ETHYL 2-(3-OXO-1-([3-(TRIFLUOROMETHYL)PHENYL]SULFONYL)-2-PIPERAZINYL)ACETATE
• ETHYL 2-[1-(2,6-DICHLOROBENZOYL)-3-OXO-2-PIPERAZINYL]ACETATE
• ETHYL 2-[1-(2,6-DIFLUOROBENZOYL)-3-OXO-2-PIPERAZINYL]ACETATE