2-AMINO-3-CYANOTHIOPHENE Chemical Properties

Melting point:

104-108 °C

Boiling point:

318℃

Density 

1.33

Flash point:

146℃

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

powder to crystalline

pka

-0.28±0.10(Predicted)

color 

White to Light yellow to Light orange

InChI

InChI=1S/C5H4N2S/c6-3-4-1-2-8-5(4)7/h1-2H,7H2

InChIKey

XVGHZFWFGXDIOU-UHFFFAOYSA-N

SMILES

C1(N)SC=CC=1C#N

CAS DataBase Reference

4651-82-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

20/21/22-36/37/38-41-37/38-22

Safety Statements 

36/37-39-26

RIDADR 

3439

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2934999090

2-AMINO-3-CYANOTHIOPHENE Usage And Synthesis

Uses

2-Aminothiophene-3-carboxynitrile is a pharmaceutical intermediate. Due to its important role in immunity, HPK1 inhibitors play an important role in malignant solid tumors or hematological malignancies (such as acute myeloid leukemia, bladder epithelial carcinoma, breast cancer, colon cancer, lung cancer, pancreatic cancer, melanoma), autoimmune diseases (such as systemic lupus erythematosus, psoriatic arthritis), and inflammatory responses.

Chemical Properties

white to light yellow crystal powder

2-AMINO-3-CYANOTHIOPHENE(4651-82-5)Related Product Information

• 2-AMINO-3-CYANO-4-METHYL-5-CARBMETHOXY THIOPHENE
• 2-AMINO-6-METHYL-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE
• 3-Thiophenecarbonitrile
• METHYL 3-AMINO-4-CYANOTHIOPHENE-2-CARBOXYLATE
• 2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBONITRILE
• 2-AMINO-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBONITRILE
• N1-(3-CYANO-4-METHYL-2-THIENYL)-2-CHLOROACETAMIDE
• 2-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBONITRILE
• 2-AMINO-5,6,7,8-TETRAHYDRO-4H-CYCLOHEPTA[B]THIOPHENE-3-CARBONITRILE
• METHYL 3-AMINO-4-CYANO-5-(DIMETHYLAMINO)THIOPHENE-2-CARBOXYLATE
• 2-AMINO-6-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE-3-CARBONITRILE
• METHYL 3-AMINO-4-CYANO-5-PIPERIDINOTHIOPHENE-2-CARBOXYLATE
• 2-CHLORO-N-(3-CYANO-2-THIENYL)ACETAMIDE
• N'-(6-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-3-CYANO-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDIN-2-YL)-N,N-DIMETHYLIMINOFORMAMIDE
• AKOS 93048
• 2-amino-4,5-dihydronaphtho[2,1-b]thiophene-1-carbonitrile
• TIMTEC-BB SBB009939
• 6-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-2-(([4-(DIMETHYLAMINO)PHENYL]METHYLENE)AMINO)-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE-3-CARBONITRILE