ChemicalBook > Product Catalog > Biochemical Engineering > Antibody > Primary Antibody > ANTI-N-(EPSILON)-CML
ANTI-N-(EPSILON)-CML
ANTI-N-(EPSILON)-CML Basic information
- Product Name:
- ANTI-N-(EPSILON)-CML
- Synonyms:
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- Anti-phospho-BCR (pTyr177) antibody produced in rabbit
- Anti-BCR (N-term) antibody produced in rabbit
- Anti-ALL antibody produced in rabbit
- Anti-BCR (Ab-177) antibody produced in rabbit
- Anti-BCR1 antibody produced in rabbit
- Anti-BCR-ABL1 antibody produced in rabbit
- Anti-breakpoint cluster region antibody produced in rabbit
- Anti-CML antibody produced in rabbit
- MF:
- C8H16N2O4
- MW:
- 204.22364
- Mol File:
- Mol File
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ANTI-N-(EPSILON)-CML Chemical Properties
- storage temp.
- -20°C
- form
- buffered aqueous solution
- biological source
- rabbit
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ANTI-N-(EPSILON)-CML Usage And Synthesis
Uses
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac.