2-BROMO-6-FLUOROBENZOYL CHLORIDE Chemical Properties

Boiling point:

236℃

Density 

1.742

Flash point:

97℃

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

liquid

color 

Colourless

Safety Information

HS Code 

2916399090

2-BROMO-6-FLUOROBENZOYL CHLORIDE Usage And Synthesis

Synthesis

General method: 2-bromo-6-fluorobenzoic acid (1.0 mmol) was mixed with excess thionyl chloride (5 mL) and reacted at reflux for 2 hours. After completion of the reaction, the excess thionyl chloride was removed by vacuum concentration to give 2-bromo-6-fluorobenzoyl chloride in quantitative yield.

References

[1] Chinese Chemical Letters, 2013, vol. 24, # 8, p. 673 - 676
[2] Patent: EP2123644, 2009, A1. Location in patent: Page/Page column 59
[3] Journal of the American Chemical Society, 2010, vol. 132, # 32, p. 11278 - 11287
[4] Synlett, 2013, vol. 24, # 19, p. 2575 - 2580
[5] Journal of the American Chemical Society, 2017, vol. 139, # 30, p. 10228 - 10231