S14-95 Chemical Properties

Boiling point:

559.0±50.0 °C(Predicted)

Density 

1.20±0.1 g/cm3(Predicted)

S14-95 Usage And Synthesis

Uses

Phenylpyropene C (S14-95), a JAK/STAT pathway inhibitor, can inhibit IFN-γ mediated expression of the reporter gene (IC50=5.4~10.8 μM). Phenylpyropene C also is an inhibitor of acyl-CoA, with an IC50 of 16.0 μM[1][2].

IC 50

ACAT: 16.0 μM (IC₅₀)

References

[1] Rho MC, et, al. Phenylpyropene C, a new inhibitor of acyl-CoA: cholesterol acyltransferase produced by Penicillium griseofulvum F1959. J Antibiot (Tokyo). 2002 Feb;55(2):211-4. DOI:10.7164/antibiotics.55.211
[2] Erkel G, et, al. S14-95, a novel inhibitor of the JAK/STAT pathway from a Penicillium species. J Antibiot (Tokyo). 2003 Apr;56(4):337-43. DOI:10.7164/antibiotics.56.337