10-DEBC HYDROCHLORIDE Chemical Properties

Melting point:

>178°C (dec.)

Boiling point:

465.1±45.0 °C(Predicted)

Density 

1.134±0.06 g/cm3(Predicted)

storage temp. 

Desiccate at +4°C

form 

White crystalline solid.

pka

10.46±0.25(Predicted)

color 

White to Off-White

10-DEBC HYDROCHLORIDE Usage And Synthesis

Uses

10-DEBC Hydrochloride is an AKT inhibitor. Study shows that efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine.

Biological Activity

Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μ M), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC 50 ~ 2-6 μ M) and induces apoptosis in rhabdomyosarcoma cells.

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