Basic information Safety Supplier Related

tridihexethyl iodide

Basic information Safety Supplier Related

tridihexethyl iodide Basic information

Product Name:
tridihexethyl iodide
Synonyms:
  • tridihexethyl iodide
  • Tridihexethl
  • Tridihexethyl
CAS:
125-99-5
MF:
C21H36NO.I
MW:
445.421
EINECS:
204-762-7
Mol File:
125-99-5.mol
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tridihexethyl iodide Chemical Properties

Melting point:
179-184°
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Safety Information

Toxicity
LD50 oral in rat: 1100mg/kg
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tridihexethyl iodide Usage And Synthesis

Originator

Pathilon,Burroughs-Wellcome,US,1955

Definition

ChEBI: Tridihexethyl iodide is an organic iodide salt. It contains a tridihexethyl.

Manufacturing Process

Acetophenone, paraformaldehyde and diethylamine are first reacted to give ω- diethylaminopropiophenone. That is reacted with cyclohexylmagnesium bromide to give 3-diethylamino-1-cyclohexyl-1-phenylpropanol-1. To 1,320 parts of methyl isobutyl ketone is added 570 parts of 3- diethylamino-1-cyclohexyl-1-phenylpropanol-1 (2 mols) and the mixture is stirred until solution is complete. Then 500 parts (3.2 molsor 60% excess) of ethyl iodide are added. After filtration, the filtrate is diluted with an additional 300 parts of methyl isobutyl ketone and the solution is then heated at the reflux temperature (108°C to 110°C) for 9 hours. After cooling to 0°C, the precipitated solid material is removed by filtration, washed with isopropyl acetate and dried. Approximately 777 parts of product is obtained or a yield of 88.6% based on as-is starting material or 92.5% based on real starting material.

Therapeutic Function

Anticholinergic

tridihexethyl iodide Supplier

Shaanxi Dideu Medichem Co. Ltd
Tel
029-81124267 15229202216
Email
1073@dideu.com