tridihexethyl iodide
tridihexethyl iodide Basic information
- Product Name:
- tridihexethyl iodide
- Synonyms:
-
- tridihexethyl iodide
- Tridihexethl
- Tridihexethyl
- CAS:
- 125-99-5
- MF:
- C21H36NO.I
- MW:
- 445.421
- EINECS:
- 204-762-7
- Mol File:
- 125-99-5.mol
tridihexethyl iodide Chemical Properties
- Melting point:
- 179-184°
tridihexethyl iodide Usage And Synthesis
Originator
Pathilon,Burroughs-Wellcome,US,1955
Definition
ChEBI: Tridihexethyl iodide is an organic iodide salt. It contains a tridihexethyl.
Manufacturing Process
Acetophenone, paraformaldehyde and diethylamine are first reacted to give ω- diethylaminopropiophenone. That is reacted with cyclohexylmagnesium bromide to give 3-diethylamino-1-cyclohexyl-1-phenylpropanol-1. To 1,320 parts of methyl isobutyl ketone is added 570 parts of 3- diethylamino-1-cyclohexyl-1-phenylpropanol-1 (2 mols) and the mixture is stirred until solution is complete. Then 500 parts (3.2 molsor 60% excess) of ethyl iodide are added. After filtration, the filtrate is diluted with an additional 300 parts of methyl isobutyl ketone and the solution is then heated at the reflux temperature (108°C to 110°C) for 9 hours. After cooling to 0°C, the precipitated solid material is removed by filtration, washed with isopropyl acetate and dried. Approximately 777 parts of product is obtained or a yield of 88.6% based on as-is starting material or 92.5% based on real starting material.
Therapeutic Function
Anticholinergic