glybuzole Chemical Properties

Melting point:

163°

Boiling point:

449.4±28.0 °C(Predicted)

Density 

1.3286 (rough estimate)

refractive index 

1.6560 (estimate)

pka

6.49±0.40(Predicted)

glybuzole Usage And Synthesis

Originator

Gludease,Kyowa Hakko,Japan,1972

Definition

ChEBI: Glybuzole is an organic molecular entity.

Manufacturing Process

15.7 g of 2-amino-5-tert-butyl-1,3,4-thiadiazole (0.1 mol) and 17.6 g of benzene sulfonyl chloride (0.1 mol) were dissolved in 150 ml dry pyridine and heated over steam for 4 hr. The pyridine was removed by distillation under reduced pressure and the residue treated with 50 ml 2N HCl. The solid product, MP 162° to 163°C. was filtered off and recrystallized once from benzene and twice from 50% aqueous EtOH.

Therapeutic Function

Oral hypoglycemic

glybuzole(1492-02-0)Related Product Information

• glybuthiazol
• 5-isopropyl-1,3,4-thiadiazol-2-amine
• 2-AMINO-5-TERT-BUTYL-1,3,4-THIADIAZOLE
• glybuzole