octaamminedichloro-mu-nitridodiruthenium(3+) trichloride, stereoisomer
octaamminedichloro-mu-nitridodiruthenium(3+) trichloride, stereoisomer Basic information
- Product Name:
- octaamminedichloro-mu-nitridodiruthenium(3+) trichloride, stereoisomer
- Synonyms:
-
- octaamminedichloro-mu-nitridodiruthenium(3+) trichloride, stereoisomer
- CAS:
- 27056-01-5
- MF:
- Cl3H16N9Ru2+2
- MW:
- 450.68
- EINECS:
- 248-191-1
- Mol File:
- 27056-01-5.mol
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octaamminedichloro-mu-nitridodiruthenium(3+) trichloride, stereoisomer Chemical Properties
- storage temp.
- 2-8°C
- form
- powder
- color
- white to dark beige
- Water Solubility
- H2O: 2mg/mL, clear
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octaamminedichloro-mu-nitridodiruthenium(3+) trichloride, stereoisomer Usage And Synthesis
Biological Activity
Ru265 is a non-cytotoxic, aqueous soluble nitrido-bridged dinuclear Ru(IV) complex th at acts as a selective mitochondrial calcium uniporter (MCU) inhibitor via a manner distinct from the oxo-bridged Ru360. Ru265 selectively reduces 100 μM histamine-induced mitochondrial [Ca2+] (mCa2+), but not cytosolic [Ca2+] (cCa2+) transient (50 ?M; HeLa) by blocking MCU-mediated mCa2+ uptake at a >10-fold greater potency as Ru360 (IC50 ~2.6 nM vs. 30 nM; HEK293T) without effecting mCa2+ efflux or membrane potential (ΔΨm). Ru265 (50 μM) protects neonatal r at ventricular myocytes from hypoxia/reoxygenation injury by preventing mPTP opening and mCa2+ overload.