(3beta,24S)-stigmast-5-en-3-ol Chemical Properties

Boiling point:

473.52°C (rough estimate)

Density 

0.9540 (rough estimate)

refractive index 

1.5000 (estimate)

Melting point:

147 °C

pka

15.03±0.70(Predicted)

(3beta,24S)-stigmast-5-en-3-ol Usage And Synthesis

Uses

γ-Sitosterol is an inhibitor for c-Myc. γ-Sitosterol inhibits the proliferation of cancer cell MCF-7 and A549 with IC50 of 240.73 μg/mL and 696.6 μg/mL, arrests the cell cycle at G2/M phase, and induces apoptosis. γ-Sitosterol upregulates the expression of cell cycle regulators cyclin B/E[1].

Definition

ChEBI: Clionasterol is a member of the class of phytosterols that is poriferast-5-ene carrying a beta-hydroxy substituent at position 3. It has a role as a plant metabolite and a marine metabolite. It is a 3beta-sterol, a member of phytosterols and a 3beta-hydroxy-Delta(5)-steroid. It derives from a hydride of a poriferastane.

References

[1] Sundarraj S, et al., γ-Sitosterol from Acacia nilotica L. induces G2/M cell cycle arrest and apoptosis through c-Myc suppression in MCF-7 and A549 cells. J Ethnopharmacol. 2012 Jun 14;141(3):803-9. DOI:10.1016/j.jep.2012.03.014