GUANIDINYL NALTRINDOLE
GUANIDINYL NALTRINDOLE Basic information
- Product Name:
- GUANIDINYL NALTRINDOLE
- Synonyms:
-
- 5'guanidinonaltrindole bis(trifluoroacetate)
- 5μ-Guanidinonaltrindole hydrate di(trifluoroacetate) salt
- 5′-Guanidinonaltrindole di(trifluoroacetate) salt hydrate
- 5'-Guanidinonaltrindole di(trifluoroacetate)
- CAS:
- 219655-57-9
- MF:
- C27H29N5O3
- MW:
- 471.558
- Mol File:
- 219655-57-9.mol
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GUANIDINYL NALTRINDOLE Chemical Properties
- storage temp.
- 2-8°C
- solubility
- H2O: soluble30mg/mL
- form
- solid
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GUANIDINYL NALTRINDOLE Usage And Synthesis
Uses
5′-Guanidinonaltrindole di(trifluoroacetate) Salt is a selective opioid receptor antagonist. It has also been utilized to develop fluorescent methods to identify phosphopantetheinyl transferase inhibitors.
Uses
5′-Guanidinonaltrindole di(trifluoroacetate) salt hydrate (GNTI) has been used as a selective κ opioid receptor antagonist:
- to study the influence of opioid receptor types on the anti-hyperalgesic effect of dipeptidyl peptidase 4 (DPP4) inhibitors in inflammation
- to study the role of κ opioid receptor in the forebrain-dependent associative task, Whisker-Trace Eyeblink conditioning (WTEB)
- to validate its inhibitory actions on Akt kinase activities
Biochem/physiol Actions
5′-Guanidinonaltrindole di(trifluoroacetate) (GNTI) is a 5‘-guanidine derivative and a selective κ opiate receptor antagonist. It is five-fold more potent and 500-fold more selective than norbinaltorphimine (nor-BNI) for the κ opioid receptor in smooth muscle preparations.