Piperazinone, 3-(2-thienyl)- (9CI)
- Product Name
- Piperazinone, 3-(2-thienyl)- (9CI)
- CAS No.
- 86696-86-8
- Chemical Name
- Piperazinone, 3-(2-thienyl)- (9CI)
- Synonyms
- Tenilsetam;3-(2-thienyl)- (9CI);Tenilsetam/Piperazinone;3-(2-Thienyl)-2-piperazinone;3-(2-Thienyl)piperazin-2-one;2-Piperazinone, 3-(2-thienyl)-;Piperazinone, 3-(2-thienyl)- (9CI);Tenilsetam - PAS 997 | CAS 997 | HR 029;Piperazinone, 3-(2-thienyl)- (9CI) USP/EP/BP
- CBNumber
- CB01052655
- Molecular Formula
- C8H10N2OS
- Formula Weight
- 182.24
- MOL File
- 86696-86-8.mol
Piperazinone, 3-(2-thienyl)- (9CI) Property
- Density
- 1.225
- InChI
- InChI=1S/C8H10N2OS/c11-8-7(9-3-4-10-8)6-2-1-5-12-6/h1-2,5,7,9H,3-4H2,(H,10,11)
- InChIKey
- BBACKDMGYMXYLE-UHFFFAOYSA-N
- SMILES
- N1CCNC(C2SC=CC=2)C1=O
N-Bromosuccinimide Price
- Product number
- B587980
- Product name
- 3-(thiophen-2-yl)piperazin-2-one
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- Axon1470
- Product name
- Tenilsetam-PAS997|CAS997|HR029
- Purity
- 99%
- Packaging
- 50mg
- Price
- $198
- Updated
- 2021/12/16
- Product number
- API0010538
- Product name
- 3-(2-THIENYL)-2-PIPERAZINONE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $275.1
- Updated
- 2021/12/16
- Product number
- 134199
- Product name
- 3-(Thiophen-2-yl)piperazin-2-one
- Purity
- 95%+
- Packaging
- 500mg
- Price
- $684
- Updated
- 2021/12/16
- Product number
- 134199
- Product name
- 3-(Thiophen-2-yl)piperazin-2-one
- Purity
- 95%+
- Packaging
- 2.500g
- Price
- $1374
- Updated
- 2021/12/16
Piperazinone, 3-(2-thienyl)- (9CI) Chemical Properties,Usage,Production
Description
Tenilsetam ((+/-)-3-(2-thienyl)-2-piperazinone; Piperazinone, 3-(2-thienyl)- (9CI)), a cognition-enhancing drug successfully used for the treatment of patients suffering from Alzheimer's disease, when included in the Maillard reaction inhibits protein crosslinking by AGEs in vitro. According to the mechanism proposed, Tenilsetam acts via covalent attachment to glycated proteins, thus blocking the reactive sites for further polymerisation reactions. A beneficial effect of Tenilsetam in Alzheimer's disease could come from the interference with AGE-derived crosslinking of amyloid plaques and a decreased inflammatory response by diminished activation of phagocytosing microglia[1].
References
[1] G Münch. “The cognition-enhancing drug tenilsetam is an inhibitor of protein crosslinking by advanced glycosylation.” Journal of Neural Transmission - Parkinson’s Disease and Dementia Section 8 3 (1994): 193–208.
Piperazinone, 3-(2-thienyl)- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
Piperazinone, 3-(2-thienyl)- (9CI) Suppliers
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View Lastest Price from Piperazinone, 3-(2-thienyl)- (9CI) manufacturers
- Product
- Piperazinone, 3-(2-thienyl)- (9CI) 86696-86-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-06
- Product
- Piperazinone, 3-(2-thienyl)- (9CI) 86696-86-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-09