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Sunitinib

Product Name
Sunitinib
CAS No.
557795-19-4
Chemical Name
Sunitinib
Synonyms
SUNITINIB BASE;SUNITINIB MALEATE;SNTI;Suniti;Sutini;SU-11248;Sutent-d4;sunitinib;SU-11248-d4;SUNITINIB-D4
CBNumber
CB9728174
Molecular Formula
C22H27FN4O2
Formula Weight
398.47
MOL File
557795-19-4.mol
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Sunitinib Property

Melting point:
189-191°C
Boiling point:
572.1±50.0 °C(Predicted)
Density 
1.2
Flash point:
299.8℃
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
8.5(at 25℃)
form 
Solid
color 
Yellow to Dark Orange
CAS DataBase Reference
557795-19-4(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
HS Code 
29337900
Hazardous Substances Data
557795-19-4(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Usbiological
Product number
170080
Product name
Sunitinib, Free base
Packaging
25mg
Price
$240
Updated
2021/12/16
Usbiological
Product number
S8032
Product name
Sunitinib Maleate
Packaging
100mg
Price
$127
Updated
2021/12/16
ChemScene
Product number
CS-1670
Product name
Sunitinib
Purity
98.96%
Packaging
1g
Price
$132
Updated
2021/12/16
Biorbyt Ltd
Product number
orb154665
Product name
Sunitinib base
Purity
>98%
Packaging
250mg
Price
$615.4
Updated
2021/12/16
Biorbyt Ltd
Product number
orb61102
Product name
Sunitinib, Free Base
Purity
>99% pure
Packaging
5G
Price
$617.1
Updated
2021/12/16
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Sunitinib Chemical Properties,Usage,Production

Description

Sunitinib is an inhibitor of multiple receptor tyrosine kinases (RTKs) involved in tumor proliferation and angiogenesis, including platelet-derived growth factor receptors (PDGFR), vascular endothelial growth factor receptors (VEGFR), and stem cell factor receptor (KIT). It was launched as an oral treatment for gastrointestinal stromal tumors (GIST) and advanced renal-cell carcinoma (RCC). In vitro, sunitib inhibits VEGFR2, PDGFRα, PDGFRβ, KIT, and FLT3 receptors with IC50 values in the 4–14nM range, and the ligand-dependent autophosphorylation of VEGFR2 and PDGFRb with IC50s of approximately 10 nM. In addition, it inhibits the growth of tumor cells expressing dysregulated target RTKs in vitro and inhibits PDGFRb- and VEGFR2-dependent tumor angiogenesis in vivo. Sunitinib exhibits broad and potent antitumor activity, causing regression in murine models of human epidermal (A431), colon (Colo205 and HT-29), lung (NCI-H226 and H460), breast (MDA-MB-435), prostate (PC3-3M-luc), and renal (786-O) cancers, and suppressing or delaying the growth of many others, including the C6 rat and SF763 T human glioma xenografts and B16 melanoma lung cancer.

Chemical Properties

Yellow Solid

Originator

Sugen (US)

Uses

Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.

Uses

Labelled Sunitinib (S820000), a multi-kinase inhibitor targeting several receptor tyrosine kinases (RTK).

Definition

ChEBI: Sunitinib is a member of pyrroles and a monocarboxylic acid amide. It has a role as an angiogenesis inhibitor, an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, a vascular endothelial growth factor receptor antagonist, an immunomodulator and a neuroprotective agent. It is functionally related to a 3-methyleneoxindole.

brand name

(Pfizer).

Clinical Use

Tyrosine kinase inhibitor:
Treatment of metastatic renal cell carcinoma (MRCC), gastrointestinal stromal tumours (GIST) and pancreatic neuroendocrine tumours (pNET)

target

VEGFR-1

Drug interactions

Potentially hazardous interactions with other drugs
Antipsychotics: avoid with clozapine (increased risk of agranulocytosis).
Antivirals: avoid concomitant use with boceprevir.
Avoid concomitant use with other inhibitors or inducers of CYP3A4. Dose alterations may be required.

Metabolism

Metabolised mainly via the cytochrome P450 isoenzyme CYP3A4 to its primary active metabolite, which itself is then further metabolised via CYP3A4.
Elimination is primarily via faeces. In a human mass balance study of [14C]sunitinib, 61% of the dose was eliminated in faeces and 16% by the renal route.

References

[1]hui ep1, lui vw, wong cs, ma bb, lau cp, cheung cs, ho k, cheng sh, ng mh, chan at. preclinical evaluation of sunitinib as single agent or in combination with chemotherapy in nasopharyngeal carcinoma. invest new drugs. 2011 dec;29(6):1123-31.

Sunitinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Sunitinib Suppliers

Canada 3 China 354 Europe 2 Germany 1 India 12 United Kingdom 5 United States 29 Global 406
shandong XuanHong Pharmaceutical Technology Co.,Ltd
Tel
0531-88801869 15562622698
Fax
0531-88801867
Email
sciencechem@163.com
Country
China
ProdList
268
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4698
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6011
Advantage
61
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd.
Tel
21-54820552
Fax
086-21-64964478
Email
188738128@qq.com
Country
China
ProdList
308
Advantage
66
Suzhou haiyu Biochem Industrial Co., LTD
Tel
512-68097639 18013585858
Fax
0512-
Email
744942877@qq.com
Country
China
ProdList
913
Advantage
62
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
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View Lastest Price from Sunitinib manufacturers

Jinan Million Pharmaceutical Co., Ltd
Product
Sunitinib 557795-19-4
Price
US $1.00-0.50/kg
Min. Order
1kg
Purity
99%
Supply Ability
200
Release date
2024-01-12
Sinoway Industrial co., ltd.
Product
Sunitinib 557795-19-4
Price
US $50.00-2.00/G/Bag
Min. Order
1G/Bag
Purity
0.99
Supply Ability
100kg
Release date
2023-11-03
shandong perfect biotechnology co.ltd
Product
sunitinib 557795-19-4
Price
US $0.00/g
Min. Order
1g
Purity
98% HPLC
Supply Ability
1kg
Release date
2023-08-02

557795-19-4, SunitinibRelated Search:

Dasatinib monohydrate Methyl 2-hydroxyethyl cellulose Ethylparaben Gefitinib Lapatinib Ethyl cyanoacetate Ethyl acrylate Teniposide Erlotinib Ethanol N,N-Dimethyl-1,4-phenylenediamine Tris(hydroxymethyl)aminomethane Ethyl acetate Imatinib ISOXADIFEN-ETHYL Dihydromyrcenol Imatinib mesylate Sunitinib Malate

  • Sunitinib--- free base
  • Sunitinib，Sutent
  • 5-(5-Fluoro-2-oxo-1,2-dihydroindol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid N-(2-diethylaminoethyl)amide
  • Suniti
  • N-[2-(diethylaMino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]Methyl}-2,4-diMethyl-1H-pyrrole-3-carboxaMide
  • SUTENT SUNITINIB
  • N-(2-diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)meth yl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
  • Sunitinib malate(TINIBS)
  • Sunitinib malate for research
  • N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide Maleate
  • SU-11248
  • N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2- dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
  • N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide Malate
  • SUNITINIB (SU 11248)
  • SU-11248;SU11248
  • Sunitinib (Sutent, SU11248)
  • SNTI
  • N-[2-DiethylaMino(ethyl-d4)]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-2,4-diMethyl-1H-pyrrole-3-carboxaMide
  • SU-11248-d4
  • Sutent-d4
  • (Z)-N-(2-(DiethylaMino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)Methyl)-2,4-diMethyl-1H-pyrrole-3-carboxaMide
  • Sunitinib (Mixture of E and Z IsoMer)
  • Sunitinib N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
  • Sunitinib, >=99%
  • sunitinib
  • SUNITINIB-D4
  • SUNITINIB MALEATE
  • n-(2-(diethylamino)ethyl)-5-((z)-(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl)-2,4-dimethyl-1h-pyrrole-3-carboxamide
  • SUNITINIB BASE
  • 1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-
  • SUNITINIBMALEATE(FORR&DONLY)
  • (Z)-N-[2-(Diethylamino)ethyl]-5-[(5-fluoro-2-oxo-3-indolinylidene)methyl]-2,4-dimethylpyrrole-3-carboxamide
  • (Z)-Sunitinib
  • Sunitinib USP/EP/BP
  • Sunitinib DISCONTINUED
  • Sunitinib free base (SU-11248)
  • SunitinibQ: What is Sunitinib Q: What is the CAS Number of Sunitinib Q: What is the storage condition of Sunitinib Q: What are the applications of Sunitinib
  • Sutent, Sunitinib, SU11248
  • Sutini
  • 557795-19-4
  • 41031-54-7
  • C22H27FN4O2C4H6O5
  • C26H33FN4O7
  • C26H31FN4O6
  • C22H27N4O2C4H6O5
  • 26H31FN4O6
  • SU-11248
  • Inhibitors
  • anti-neoplastic
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sunitinib
  • Molecular Targeted Antineoplastic
  • Heterocyclic Compounds
  • Pharmaceutical intermediate
  • API
  • Tyrosine Kinase Inhibitors