Chemical Properties Uses of Biology Uses
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Tris Base

Chemical Properties Uses of Biology Uses
Product Name
Tris Base
CAS No.
77-86-1
Chemical Name
Tris Base
Synonyms
THAM;TRIS;Trizma;Tham-E;TRISMAT;8VTE 1L;riladyl;thamset;Trisamin;NSC-6365
CBNumber
CB8336488
Molecular Formula
C4H11NO3
Formula Weight
121.14
MOL File
77-86-1.mol
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Tris Base Property

Melting point:
167-172 °C(lit.)
Boiling point:
219-220 °C10 mm Hg(lit.)
Density 
1,353 g/cm3
vapor pressure 
0.0267 hPa (20 °C)
refractive index 
1.4170 (estimate)
Flash point:
219-220°C/10mm
storage temp. 
2-8°C
solubility 
H2O: 4 M at 20 °C, clear, colorless
form 
crystalline
color 
white
PH
10.5-12.0(4 m in water, 25 °C)
PH Range
7 - 9
pka
8.1(at 25℃)
Water Solubility 
550 g/L (25 ºC)
λmax
λ: 260 nm Amax: 0.10
λ: 280 nm Amax: 0.08
Sensitive 
Hygroscopic
Merck 
14,9772
BRN 
741883
Stability:
Stable. Incompatible with bases, strong oxidizing agents. Protect from moisture.
InChIKey
LENZDBCJOHFCAS-UHFFFAOYSA-N
CAS DataBase Reference
77-86-1(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Propanediol, 2-amino-2-(hydroxymethyl)-(77-86-1)
EPA Substance Registry System
Tris(hydroxymethyl)aminomethane (77-86-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39-24/25-23
WGK Germany 
2
RTECS 
TY2900000
3
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29221980
Hazardous Substances Data
77-86-1(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rat > 5000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
252859
Product name
Tris(hydroxymethyl)aminomethane
Purity
ACS reagent, ≥99.8%
Packaging
100g
Price
$78.5
Updated
2020/08/18
Sigma-Aldrich
Product number
1698002
Product name
Tromethamine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
125mg
Price
$297
Updated
2020/08/18
TCI Chemical
Product number
A0321
Product name
Tris(hydroxymethyl)aminomethane
Purity
>99.0%(T)
Packaging
25g
Price
$13
Updated
2020/06/24
TCI Chemical
Product number
A0321
Product name
Tris(hydroxymethyl)aminomethane
Purity
>99.0%(T)
Packaging
500g
Price
$87
Updated
2020/06/24
Alfa Aesar
Product number
A18494
Product name
Tris(hydroxymethyl)aminomethane, 99%
Packaging
100g
Price
$26.9
Updated
2020/06/24
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Tris Base Chemical Properties,Usage,Production

Chemical Properties

White crystal or powder. Melting point 171-172℃, boiling point 219-220℃/1.3kPa, soluble in ethanol and water, slightly soluble in ethyl acetate, benzene, insoluble in ether, carbon tetrachloride,copper,aluminum corrosion effects,irritant.

Uses of Biology

Tris base, also known as THAM, is widely used as a biological buffer or as a component of buffer formulations such as TAE and TBE buffers. Tris has a pKa of 8.06 and is very useful in the biology and biochemistry lab because it has buffering capabilities in the range of the typical physiological pH of most living organisms (pH 7.0-9.0). Tris has been reported to interfere with the activity of a number of enzymes, it should therefore be used carefully when studying proteins.

Uses

1, Tris buffer, only nucleic acids and proteins are widely used as solvents.
2, Tris is used for protein crystal growth under different pH conditions.
3, Tris buffer having a low ionic strength can be used nematode (C. elegans) is formed lamin (lamin) intermediate fibers.
4, Tris is a major component of protein electrophoresis buffer.
5, Tris for the preparation of a surfactant, a vulcanization accelerator, and some drug intermediates.
6, Tris titrated also used as standard.

Chemical Properties

White, crystalline solid. PH (0.1M aqueous solution) 10.6, corrosive to copper, brass, aluminum. Solubility in water 80 g/100 cc (20C). Combustible.

Originator

Trisaminol,Bellon,France,1964

Uses

tromethamine can help mask odor in a formulation. It is also used as a buffer, keeping product pH stable.

Uses

In the synthesis of surface-active agents, vulcanization accelerators, pharmaceuticals. As emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, leather dressings, textile specialties, polishes, cleaning Compounds, so-called soluble oils. Absorbent for acidic gases. Biological buffer.

Manufacturing Process

Nitromethane is reacted with formaldehyde to give tris(hydroxymethyl)nitromethane in an initial step. This intermediate may be reduced by catalytic hydrogenation (US Patent 2,174,242) or by electrolytic reduction (US Patent 2,485,982).

brand name

Tham (Hospira).

Therapeutic Function

Antacid

Biological Activity

Commonly used laboratory reagent

Purification Methods

TRIS can ordinarily be obtained in highly pure form suitable for use as an acidimetric standard. If only impure material is available, it should be crystallised from 20% EtOH, aqueous MeOH (m 171.1o) or isopropanol (m 172-173o). Dry it in a vacuum desiccator over P2O5 or CaCl2. Alternatively, it is dissolved in twice its weight of water at 55-60o, filtered, concentrated to half its volume and poured slowly, with stirring, into about twice its volume of EtOH. The crystals which separate on cooling to 3-4o are filtered off, washed with a little MeOH, air dried by suction, then finally ground and dried in a vacuum desiccator over P2O5. It has also been recrystallised from water, MeOH or aqueous MeOH, and vacuum dried at 80o for 2 days. [Beilstein 4 H 303, 4 III 857, 4 IV 1903.]

Tris Base Preparation Products And Raw materials

Raw materials

Preparation Products

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Tris Base Suppliers

Shangqiu tengfei biotechnology co., ltd
Tel
;0370-63313-88
Email
1303279042@qq.com;1303279042@qq.com
Country
China
ProdList
1
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
400-900-4166
Email
3007522970@qq.com
Country
China
ProdList
52519
Advantage
58
Spectrum Chemical Manufacturing Corp.
Tel
021-67601398-809
Fax
021-57711696
Email
marketing_china@spectrumchemical.com;
Country
China
ProdList
9688
Advantage
60
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
021-20337333-801
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24983
Advantage
65
Nanjing Search Biotech Co., Ltd
Tel
025-85860978-0
Fax
025-85860962
Email
sales@searchbio.com.cn;
Country
China
ProdList
183
Advantage
68
Shanghai Uteam Biotechnology Co., Ltd.
Tel
021-65211385-102
Email
3338195766@QQ.com;
Country
China
ProdList
5183
Advantage
55
Dongyang Baihang Chemical Co., Ltd.
Tel
0579-86886233-
Fax
QQ:355093164
Email
355093164@qq.com
Country
China
ProdList
80
Advantage
58
BOC Sciences
Email
info@bocsci.com
Country
United States
ProdList
9983
Advantage
65
Hangzhou changru chemical co., ltd
Tel
;
Email
534091519@qq.com;534091519@qq.com
Country
China
ProdList
92
Advantage
58
Hubei maoerwo biomedical Co., Ltd
Tel
15387162512
Email
664219562@qq.com
Country
CHINA
ProdList
294
Advantage
58
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View Lastest Price from Tris Base manufacturers

Jinan Finer Chemical Co., Ltd
Product
Trometamol 77-86-1
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
200mt
Release date
2020-11-11
Shenyang Simchoice Chemical Co.,Ltd
Product
TRIS 77-86-1
Price
US $25.00/Kg/Drum
Min. Order
100KG
Purity
99.5%
Supply Ability
20ton
Release date
2020-11-27
Hubei Xindesheng Material Technology Co., Ltd.
Product
tris hydroxymethyl methyl aminomethane 77-86-1
Price
US $30.00-22.50/公斤
Min. Order
1公斤
Purity
>99%(HPLC)
Supply Ability
20T
Release date
2020-10-29

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