ChemicalBook > CAS DataBase List > Lithium bis(trimethylsilyl)amide

Lithium bis(trimethylsilyl)amide

Product Name
Lithium bis(trimethylsilyl)amide
CAS No.
4039-32-1
Chemical Name
Lithium bis(trimethylsilyl)amide
Synonyms
LHMDS;LITHI;LIHMDS;HMDS Li;LiHMDS(1M);Lithium bis(trimethy;ithium bis(trimethyL;LITHIUM HMDS 30% IN THF;LITHIUM HEXAMETHYLDISILAZIDE;LITHIUM HEXAMETHYLDISILAZANE
CBNumber
CB2202677
Molecular Formula
C6H18LiNSi2
Formula Weight
167.33
MOL File
4039-32-1.mol
More
Less

Lithium bis(trimethylsilyl)amide Property

Melting point:
73°C
Boiling point:
55-56 °C
Density 
0.860 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.425(lit.)
Flash point:
48 °F
storage temp. 
Store below +30°C.
solubility 
hydrolysis
form 
Powder
color 
White
Specific Gravity
0.891
Specific Gravity
0.716
Water Solubility 
hydrolysis
Sensitive 
Air & Moisture Sensitive
Hydrolytic Sensitivity
8: reacts rapidly with moisture, water, protic solvents
Hydrolytic Sensitivity
7: reacts slowly with moisture/water
BRN 
3567910
InChIKey
YNESATAKKCNGOF-UHFFFAOYSA-N
CAS DataBase Reference
4039-32-1(CAS DataBase Reference)
EPA Substance Registry System
Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, lithium salt (4039-32-1)
More
Less

Safety

Hazard Codes 
F,C,N
Risk Statements 
11-34-48/20-63-65-67-51/53-35-20-62-14-40-37-19
Safety Statements 
9-16-26-29-33-36/37/39-45-61-62-57-43
RIDADR 
UN 2925 4.1/PG 2
WGK Germany 
3
10-23
TSCA 
Yes
HazardClass 
4.3
PackingGroup 
II
HS Code 
29319090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H228Flammable solid

H302Harmful if swallowed

H303May be harmfulif swallowed

H304May be fatal if swallowed and enters airways

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H333May be harmful if inhaled

H335May cause respiratory irritation

H336May cause drowsiness or dizziness

H341Suspected of causing genetic defects

H351Suspected of causing cancer

H361Suspected of damaging fertility or the unborn child

H371May cause damage to organs

H372Causes damage to organs through prolonged or repeated exposure

H373May cause damage to organs through prolonged or repeated exposure

H402Harmful to aquatic life

H411Toxic to aquatic life with long lasting effects

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P402Store in a dry place.

P405Store locked up.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
224367
Product name
Lithium bis(trimethylsilyl)amide solution
Purity
1.0 M in hexanes
Packaging
100ml
Price
$83.3
Updated
2021/12/16
Sigma-Aldrich
Product number
224367
Product name
Lithium bis(trimethylsilyl)amide solution
Purity
1.0 M in hexanes
Packaging
8l
Price
$985
Updated
2021/12/16
Sigma-Aldrich
Product number
225770
Product name
Lithium bis(trimethylsilyl)amide solution
Purity
1.0?M in THF
Packaging
18 L
Price
$2420
Updated
2021/12/16
Sigma-Aldrich
Product number
775053
Product name
Lithium bis(trimethylsilyl)amide solution
Purity
0.5 M in 2-methyltetrahydrofuran
Packaging
100ml
Price
$74.9
Updated
2021/03/22
Sigma-Aldrich
Product number
775053
Product name
Lithium bis(trimethylsilyl)amide solution
Purity
0.5 M in 2-methyltetrahydrofuran
Packaging
4x25ml
Price
$115
Updated
2021/03/22
More
Less

Lithium bis(trimethylsilyl)amide Chemical Properties,Usage,Production

Chemical Properties

light yellow to yellow crystalline powder

Physical properties

distillable low-melting solid; mp 70–72 °C, bp 115 °C/1mmHg. LHMDS is a cyclic trimer in the solid state,3 whereas in benzene solution it exists in a monomer–dimer equilibrium. LHMDS exists as a tetramer-dimer mixture in hydrocarbons and as a dimer-monomer mixture in THF and ether. Treatment of LHMDS with trialkylamines increases the monomer concentration, whereas the use of diamines affords exclusively the corresponding chelated monomer. LHMDS is less soluble, less basic, more stable, and much less sensitive to air compared to lithium diisopropylamide. pKa 29.5 (THF, 27 °C).

Uses

Lithium bis(trimethylsilyl)amide is used as nonnucleophilic base to generate kinetic ketone and ester enolates. It is considerably more selective than LDA and undesired reductions (e.g., of nonenolizable ketones observed in the case of LDA) can be avoided by using LHMDS.

Uses

Lithium Hexamethyldisilazide is widely used as strong nonnucleophilic base

Uses

Lithium bis(trimethylsilyl)amide is a base used in preparation of dienes and enolates. It is used to catalyze the addition of phosphine P-H bonds to carbodiimides leading to phosphaguanidines. Lithium bis(trimethylsilyl)amide is also used in a novel three-step synthesis of disubstituted 1,2,5-thiadiazoles.

Preparation

It is conveniently prepared by the reaction of hexamethyldisilazane with n-butyllithium in hexane. For most uses the hexane is then evaporated and replaced with THF.

General Description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product, 0.5 M in 2-methyltetrahydrofuran aligns with Safer Solvents and Auxiliaries, Use of Renewable Feedstocks and Inherently Safer Chemistry for Accident Prevention. Click here for more information.

Lithium bis(trimethylsilyl)amide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Lithium bis(trimethylsilyl)amide Suppliers

Wuhan rosenger Chemical Technology Co., Ltd.
Tel
Email
2359502153@qq.com
Country
China
ProdList
77
Advantage
58
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
Chengdu Hongsheng Sci-Tech Development Co..,Ltd
Tel
028-37690186-
Fax
028-37690518
Email
cdchemical@163.com;
Country
China
ProdList
59
Advantage
58
Adamas Reagent, Ltd.
Tel
400-600-9262
Email
bxy@titansci.com
Country
China
ProdList
13915
Advantage
59
Panjin Infinity Scientific CO. LTD
Tel
400-106-2016
Fax
QQ25788917
Email
hao@infsci.com
Country
China
ProdList
292
Advantage
58
Lianyungang Jiezhong Pharmaceutical Technology Co., Ltd
Tel
;
Fax
13165449089
Email
2124455948@qq.com;2124455948@qq.com
Country
China
ProdList
66
Advantage
58
Sigma-Aldrich
Tel
021-61415566- ;
Email
orderCN@merckgroup.com;orderCN@merckgroup.com
Country
China
ProdList
50837
Advantage
80
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100-
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9636
Advantage
66
Sichuan Weibo Science and Technology Co.,Ltd
Tel
028-65199188-
Fax
028-65199189
Email
ellnn@163.com
Country
China
ProdList
12
Advantage
58
Jiaxing Resenpai Biotechnology Co., LTD
Tel
;
Email
2733037641@qq.com;2733037641@qq.com
Country
China
ProdList
44
Advantage
58
More
Less

View Lastest Price from Lithium bis(trimethylsilyl)amide manufacturers

Hebei Guanlang Biotechnology Co., Ltd.
Product
Lithium bis(trimethylsilyl)amide 4039-32-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-12-13
Zhuozhou Wenxi import and Export Co., Ltd
Product
Lithium bis(trimethylsilyl)amide 4039-32-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Lithium bis(trimethylsilyl)amide 4039-32-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

4039-32-1, Lithium bis(trimethylsilyl)amideRelated Search:


  • 1,1,1,3,3,3-HEXAMETHYLDISILAZAN LITHIUMSALZ
  • 1,1,1,3,3,3-HEXAMETHYLDISILAZANE LITHIUM SALT
  • HEXAMETHYLDISILAZANE LITHIUM SALT
  • LHMDS
  • LIHMDS
  • LITHIUM HEXAMETHYLDISILAZANE
  • LITHIUM HEXAMETHYLDISILAZIDE
  • LITHIUM-BIS-(TRIMETHYLSILYL)-AMID
  • LITHIUM BIS(TRIMETHYLSILYL)AMIDE
  • Lithium bis(trimethylsilyl)amide, 0.9-1.1M in hexane, packaged under Argon in resealable ChemSeal bottles
  • Lithium bis(trimethylsilyl)amide, 1.0m solution in methyl tert-butyl ether
  • Lithium bis(trimethylsilyl)amide1.0M sol. in methyl tert-butyl etherAcroSeal§3
  • Lithium bis(trimethylsilyl)amide1M solution in THF/EthylbenzeneAcroSeal§3
  • Lithium bis(trimethylsilyl)amide0.9M solution in methylcyclohexaneAcroSeal§3
  • (Lithioimino)bis(trimethylsilane)
  • [Di(trimethylsilyl)amino] lithium
  • 2-Lithio-1,1,1,3,3,3-hexamethylpropanedisilazane
  • 2-Lithiohexamethylpropanedisilazane
  • Lithioiminobis(trimethylsilane)
  • N-Lithio-N-(trimethylsilyl)-α,α,α-trimethylsilanamine
  • Lithium Hexamethyldisilazide,LiHMDS
  • N-LITHIOHEXAMETHYLDISILAZANE
  • 1,1,1-trimethyl-n-(trimethylsilyl)-silanaminlithiumsalt
  • lithium-bis-(trimethylsilyl)-amide(30%inthf)
  • Lithium bis(trimethylsilyl)amide, 20% (ca 1.06M) soln. in THF/ethylbenzene
  • Lithium bis(trimethylsilyl)amide, 0.9-1.1M in hexane, packaged under Argon in resealable ChemSealTM bottles
  • Lithium Hexamethyldisilazide (29% in Tetrahydrofuran, ca. 1.6mol/L)
  • Lithium bis(trimethylsilyl)amide, 0.9-1.1M in hexane, packaged under Argon in resealable ChemSeal^t bottles
  • Lithium bis(trimethylsilyl)amide, 0.9-1.1M in hexane, packaged under Argon in resealable ChemSeal^t
  • Lithium bis(trimethylsilyl)amide,1.3M solution in toluene/ethylbenzene
  • Lithium bis(trimethylsilyl)amide, 1.3M solution in THF
  • Lithium bis(trimethylsilyl)amide,1.3M solution in hexanes/ethylbenzene
  • LithiuM Bis(triMethylsilyl)aMide (ca. 26% in Tetrahydrofuran, ca. 1.3Mol/L)
  • LithiuM bis(triMethylsilyl)aMide, stab. with hexane
  • Hexamethyldisilazane Lithium Salt LiHMDS Lithium Hexamethyldisilazide
  • LithiuM bis(triMethylsilyl)aMide, 15% in 2-MeTHF/Ethylbenzene, AcroSeal
  • LITHIUM HEXAMETHYLDISILAZIDE, 1.25M in tetrahydrofuran
  • LithiuM bis(triMethylsilyl) aMide, titr 95%
  • LithiuM bis(triMethylsilyl)aMide solution 1.0 M in THF
  • LithiuM bis(triMethylsilyl)aMide, 1.0 M solution in THF
  • LithiuM bis(triMethylsilyl)aMide, 1.0 M solution in THF, J&KSeal
  • HMDS Li
  • LithiuM bis(triMethylsilyl)aMide solution 1 M in toluene
  • LithiuM bis(triMethylsilyl)aMide solution 1.0 M in hexanes
  • LithiuM bis(triMethylsilyl)aMide, 0.5 M solution in toluene, SpcSeal
  • Double triMethyl silyl aMino lithiuM
  • LithiuM bis(triMethylsilyl)aMide, 1.0 M solution in THF, SpcSeal
  • LithiuM bis(triMethylsilyl)aMide, 1.0M solution in Methyl tert-butyl ether, SpcSeal
  • Lithium bis(trimethylsilyl)amide, 1M in THF
  • LiHMDS(1M)
  • N,N-Bis(trimethylsilyl)amidelithium, 97%, 20% THF solution
  • Lithium bis(trimethylsilyl)amide, 1M in toluene
  • Lithium Hexamethyldisilazide (1M in Tetrahydrofuran)
  • Lithium bis(trimethylsilyl)amide, 1.0M sol. in methyl tert-butyl ether
  • Lithium bis(trimethylsilyl)amide, 1M solution in THF/Ethylbenzene
  • Hexamethyldisilazanelithiumsalt24%THF
  • Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, lithium salt
  • lithium bis(trimethylsilyl)amide, 0.9-1.1m in hexane, packaged under argon in resealable chemseal