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Ethylparaben

Product Name
Ethylparaben
CAS No.
120-47-8
Chemical Name
Ethylparaben
Synonyms
Ethyl;Sobrol A;nipazina;solbrola;Of ethyl;Solbro A;Easeptol;Keloform;Mycocten;napagina
CBNumber
CB5119772
Molecular Formula
C9H10O3
Formula Weight
166.17
MOL File
120-47-8.mol
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Ethylparaben Property

Melting point:
114-117 °C (lit.)
Boiling point:
297-298 °C (lit.)
Density 
1.1708 (rough estimate)
vapor pressure 
0.00012 hPa (25 °C)
refractive index 
1.5286 (estimate)
Flash point:
297-298°C
storage temp. 
2-8°C
solubility 
Very slightly soluble in water, freely soluble in ethanol (96 per cent) and in methanol.
pka
8.31±0.13(Predicted)
form 
Crystalline Powder
color 
White
PH
4.5-5.5 (H2O, 20°C) (saturated solution)
Water Solubility 
Slightly soluble in water.
Merck 
14,3837
BRN 
1101972
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference
120-47-8(CAS DataBase Reference)
NIST Chemistry Reference
Ethylparaben(120-47-8)
EPA Substance Registry System
Ethylparaben (120-47-8)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
1
RTECS 
DH2190000
Autoignition Temperature
495 °C
TSCA 
Yes
HS Code 
29182930
Hazardous Substances Data
120-47-8(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
111988
Product name
Ethyl 4-hydroxybenzoate
Purity
ReagentPlus , 99%
Packaging
5g
Price
$16.8
Updated
2020/08/18
Sigma-Aldrich
Product number
111988
Product name
Ethyl 4-hydroxybenzoate
Purity
ReagentPlus , 99%
Packaging
100g
Price
$28.7
Updated
2020/08/18
Sigma-Aldrich
Product number
E2425000
Product name
Ethyl parahydroxybenzoate
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
1.00887
Product name
Ethyl 4-hydroxybenzoate
Purity
EMPROVE? ESSENTIAL Ph Eur,BP,JP,NF
Packaging
5 kg
Price
$388
Updated
2021/03/22
Sigma-Aldrich
Product number
1.00887
Product name
Ethyl 4-hydroxybenzoate
Purity
EMPROVE? ESSENTIAL Ph Eur,BP,JP,NF
Packaging
25 kg
Price
$1290
Updated
2021/03/22
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Ethylparaben Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Chemical Properties

Ethylparaben occurs as a white, odorless or almost odorless, crystalline powder.

Uses

An antimicrobial

Uses

bronchodilator, tocolytic

Uses

Preservative for pharmaceuticals.

Production Methods

Ethylparaben is prepared by the esterification of p-hydroxybenzoic acid with ethanol (95%).

Synthesis Reference(s)

The Journal of Organic Chemistry, 39, p. 3343, 1974 DOI: 10.1021/jo00937a007

Pharmaceutical Applications

Ethylparaben is widely used as an antimicrobial preservative in cosmetics,food products, and pharmaceutical formulations.
It may be used either alone or in combination with other paraben esters or with other antimicrobial agents. In cosmetics it is one of the most frequently used preservatives.
The parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds.
Owing to the poor solubility of the parabens, paraben salts, particularly the sodium salt, are frequently used. However, this may cause the pH of poorly buffered formulations to become more alkaline.

Contact allergens

This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.

Safety

Ethylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics, food products, and oral and topical pharmaceutical formulations.
Systemically, no adverse reactions to parabens have been reported, although they have been associated with hypersensitivity reactions. Parabens, in vivo, have also been reported to exhibit estrogenic responses in fish.(10) The WHO has set an estimated total acceptable daily intake for methyl-, ethyl-, and propylparabens at up to 10 mg/kg body-weight.
LD50 (mouse, IP): 0.52 g/kg
LD50 (mouse, oral): 3.0 g/kg

storage

Aqueous ethylparaben solutions at pH 3–6 can be sterilized by autoclaving, without decomposition. At pH 3–6, aqueous solutions are stable (less than 10% decomposition) for up to about 4 years at room temperature, while solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days at room temperature).
Ethylparaben should be stored in a well-closed container in a cool, dry place.

Incompatibilities

The antimicrobial properties of ethylparaben are considerably reduced in the presence of nonionic surfactants as a result of micellization. Absorption of ethylparaben by plastics has not been reported, although it appears probable given the behavior of other parabens. Ethylparaben is coabsorbed on silica in the presence of ethoxylated phenols. Yellow iron oxide, ultramarine blue, and aluminum silicate extensively absorb ethylparaben in simple aqueous systems, thus reducing preservative efficacy.
Ethylparaben is discolored in the presence of iron and is subject to hydrolysis by weak alkalis and strong acids.

Regulatory Status

Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral, otic, and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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Ethylparaben Suppliers

Changzhou Yanji Biotechnology Co., Ltd.
Tel
0519-83556355
Fax
-
Email
shikewei397@163.com
Country
China
ProdList
3786
Advantage
55
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
Tel
1867-8026865- ;
Fax
15336364684
Email
sdfantai@163.com;sdfantai@163.com
Country
China
ProdList
787
Advantage
58
ShangHai Anpel Co, Ltd.
Tel
021-54890099
Email
shanpel@anpel.com.cn
Country
CHINA
ProdList
1584
Advantage
58
Taian jiangzhou biology science and technology co., ltd
Tel
0538-5498888-
Fax
QQ:239546874
Email
239546874@qq.com
Country
China
ProdList
37
Advantage
58
Tianjin Zhongxin Chemtech Co., Ltd.
Tel
022-66880623;022-89880623
Fax
86(0)22-66880086
Email
sales@tjzxchem.com;sales@tjzxchem.com
Country
China
ProdList
617
Advantage
60
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
Chembest Research Laboratories Limited
Tel
021-20908456-
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5948
Advantage
61
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
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View Lastest Price from Ethylparaben manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Ethylparaben 120-47-8
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-11-17
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Ethylparaben 120-47-8
Price
US $0.00/KG
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2020-11-17
Wuhan Mulei New Material Technology Co. Ltd
Product
Ethylparaben 120-47-8
Price
US $20.00/Kg/Drum
Min. Order
25Kg/Drum
Purity
99.99%
Supply Ability
1 ton per week
Release date
2021-04-02

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