3,5-Dichloro-4-hydroxybenzoic acid

Product Name: 3,5-Dichloro-4-hydroxybenzoic acid
CAS No.: 3336-41-2
Chemical Name: 3,5-Dichloro-4-hydroxybenzoic acid
Synonyms: AKOS BBS-00006921;RARECHEM AL BE 0933;Dotinurad Impurity 34;Dotinurad Impurity 24;LABOTEST-BB LT00454970;Tetrahydrozoline Impurity 4;3,5-dichloro-4-hydroxybenzoate;3,5-dichloro-4-hydroxy-benzoicaci;,5-Dichloro-4-hydroxybenzoic acid;3,5-DICHLORO-4-HYDROXYBENZOIC ACID
CBNumber: CB0480631
Molecular Formula: C7H4Cl2O3
Formula Weight: 207.01
MOL File: 3336-41-2.mol

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3,5-Dichloro-4-hydroxybenzoic acid Property

Melting point:: 264-266 °C (lit.)
Boiling point:: 297.29°C (rough estimate)
Density: 1.5281 (rough estimate)
refractive index: 1.4845 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.83±0.10(Predicted)
color: White to Off-White
BRN: 2616297
InChI: InChI=1S/C7H4Cl2O3/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1-2,10H,(H,11,12)
InChIKey: AULKDLUOQCUNOK-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC(Cl)=C(O)C(Cl)=C1
CAS DataBase Reference: 3336-41-2(CAS DataBase Reference)
NIST Chemistry Reference: 3,5-Dichloro-4-hydroxybenzoic acid(3336-41-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
RTECS: DG7502000
HS Code: 29182900
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D64007
Product name: 3,5-Dichloro-4-hydroxybenzoic acid
Purity: 97%
Packaging: 25g
Price: $111
Updated: 2023/06/20

TCI Chemical

Product number: D0373
Product name: 3,5-Dichloro-4-hydroxybenzoic Acid
Purity: >98.0%(T)
Packaging: 5g
Price: $28
Updated: 2025/07/31

TCI Chemical

Product number: D0373
Product name: 3,5-Dichloro-4-hydroxybenzoic Acid
Purity: >98.0%(T)
Packaging: 25g
Price: $77
Updated: 2025/07/31

TRC

Product number: D438698
Product name: 3,5-Dichloro-4-hydroxybenzoic acid
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 082034
Product name: 3,5-Dichloro-4-hydroxybenzoic acid
Purity: 95%
Packaging: 25g
Price: $49
Updated: 2021/12/16

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3,5-Dichloro-4-hydroxybenzoic acid Chemical Properties,Usage,Production

Chemical Properties

White to light yellow crystal powder

Uses

3,5-Dichloro-4-hydroxybenzoic Acid can be used as cyclin dependent kinase inhibitors to treat cell proliferative disorders, such as, cancer.

Definition

ChEBI: 3,5-dichloro-4-hydroxybenzoic acid is a derivative of p-salicylic acid with chloro- substituents at C-3 and C-5 of the benzene ring. It is a monohydroxybenzoic acid and a dichlorobenzene. It is functionally related to a benzoic acid and a 4-hydroxybenzoic acid. It is a conjugate acid of a 3,5-dichloro-4-hydroxybenzoate.

Synthesis

99-96-7

3336-41-2

The general procedure for the synthesis of 3,5-dichloro-4-hydroxybenzoic acid from 4-hydroxybenzoic acid was as follows: 10 mL of 33% hydrogen peroxide solution was slowly added to a suspension of 10 mL hydrochloric acid and 20 mL water containing 3.5 g (0.025 mol) of 4-hydroxybenzoic acid. Upon completion of the reaction, the resulting white precipitate was collected by filtration, washed well with hot water and purified by recrystallization from ethanol. Finally, 3.19 g of white crystalline product was obtained in 63.5% yield with a melting point of 265 °C. The 1H NMR spectral data of the product was as follows (ppm): 7.84 (s, 2H, H2,6). Elemental analysis results: measured values (%) C 40.64, H 1.87, Cl 34.34; calculated values (%) C 40.58, H 1.93, Cl 34.30 (molecular formula: C7H4Cl2O2).

References

[1] Organic Process Research and Development, 1999, vol. 3, # 1, p. 10 - 16
[2] Russian Journal of General Chemistry, 2015, vol. 85, # 3, p. 577 - 583
[3] Zh. Obshch. Khim., 2015, vol. 85, # 3, p. 413 - 419,7
[4] Zhurnal Obshchei Khimii, 1949, vol. 19, p. 1167,1168
[5] Chem. Zentralbl., 1950, vol. 121, p. 1063

3,5-Dichloro-4-hydroxybenzoic acid Preparation Products And Raw materials

Raw materials

Ethylparaben

Preparation Products

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3,5-Dichloro-4-hydroxybenzoic acid Suppliers

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View Lastest Price from 3,5-Dichloro-4-hydroxybenzoic acid manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Dotinurad Impurity 34 3336-41-2
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 5g
Release date: 2025-05-29

Shaanxi Dideu New Materials Co. Ltd

Product: 3,5-Dichloro-4-hydroxybenzoic acid 3336-41-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-18

Shaanxi Dideu Medichem Co. Ltd

Product: 3,5-Dichloro-4-hydroxybenzoic acid 3336-41-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-07-11

3336-41-2, 3,5-Dichloro-4-hydroxybenzoic acidRelated Search:

Butylparaben 3-CHLORO-4-HYDROXYBENZOIC ACID 2-Chloro-4-hydroxybenzoic acid 4-Hydroxybenzhydrazide 3-Hydroxybenzoic acid 4-Hydroxybenzoic acid Methyl 3,5-dihydroxybenzoate 2'-Hydroxy-3-phenylpropiophenone Benzylparaben 3,5-Dihydroxybenzoic acid Salicylic acid Isopropylparaben Methylparaben 2,5-Dihydroxybenzoic acid 3,5-Dichlorobenzoic acid 3,5-DICHLORO-4-HYDROXYBENZOIC ACID METHYL ESTER 3,5-DICHLORO-4-HYDROXYBENZOIC ACID ETHYL ESTER 3,5-DICHLORO-2-HYDROXYBENZOIC ACID

3,5-dichloro-4-hydroxybenzoate

3,5-Dichloro-4-hydroxybenzoic acid,97%

3,5-Dichloro-4-hydroxybenzoic acid, 97% 5GR

3,5-dichloro-4-hydroxy-benzoicaci

Benzoic acid, 3,5-dichloro-4-hydroxy-

4-Hydroxy-3,5-Dichloro Benzoic Acid

3,5-DICHLORO-4-HYDROXYBENZOIC ACID

AKOS BBS-00006921

LABOTEST-BB LT00454970

RARECHEM AL BE 0933

3,5-Dichloro-4-hydroxybenzoic Acid &gt

Tetrahydrozoline Impurity 4

,5-Dichloro-4-hydroxybenzoic acid

Dotinurad Impurity 34

Dotinurad Impurity 24

2-(benzo[d]thiazol-3(2H)-yl)-1-(3,5-dichloro-4-methoxyphenyl)ethanone

3336-41-2

C7H4Cl2O3

C7H4O3Cl2

Building Blocks

Carbonyl Compounds

Carboxylic Acids

C7

Organic Building Blocks

Building Blocks

Carbonyl Compounds

Chemical Synthesis

Organic Building Blocks

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Carboxylic Acids

Phenyls & Phenyl-Het

Benzoic acid

Carboxylic Acids

Phenyls & Phenyl-Het

C7

Carbonyl Compounds

Acids & Esters

Chlorine Compounds

Phenols