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3-Hydroxybenzoic acid

Product Name
3-Hydroxybenzoic acid
CAS No.
99-06-9
Chemical Name
3-Hydroxybenzoic acid
Synonyms
M-HYDROXYBENZOIC ACID;3-hydroxybenzoate;Benzoic acid, 3-hydroxy-;m-Salicylic acid;meta-Hydroxybenzoic acid;m-Hba;m-salicylicacid;m-Salicylic Aci;3-Carboxyphenol;m-Hydroxybenzoic
CBNumber
CB4854760
Molecular Formula
C7H6O3
Formula Weight
138.12
MOL File
99-06-9.mol
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3-Hydroxybenzoic acid Property

Melting point:
200-203 °C (lit.)
Boiling point:
213.5°C (rough estimate)
Density 
1.4850
refractive index 
1.4600 (estimate)
FEMA 
4431 | 3-HYDROXYBENZOIC ACID
Flash point:
220 °C
storage temp. 
Store below +30°C.
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
4.06(at 19℃)
form 
Powder
color 
White to off-white
PH
3 (H2O)Aqueous solution
Water Solubility 
slightly soluble
BRN 
508160
InChIKey
IJFXRHURBJZNAO-UHFFFAOYSA-N
LogP
1.50
CAS DataBase Reference
99-06-9(CAS DataBase Reference)
NIST Chemistry Reference
Benzoic acid, 3-hydroxy-(99-06-9)
EPA Substance Registry System
m-Hydroxybenzoic acid (99-06-9)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
DH1924980
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29182990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H20008
Product name
3-Hydroxybenzoic acid
Purity
ReagentPlus , 99%
Packaging
5g
Price
$36.4
Updated
2024/03/01
Sigma-Aldrich
Product number
36333
Product name
3-Hydroxybenzoic acid
Purity
analytical standard
Packaging
100mg
Price
$61.3
Updated
2022/05/15
TCI Chemical
Product number
H0205
Product name
3-Hydroxybenzoic Acid
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$23
Updated
2024/03/01
TCI Chemical
Product number
H0205
Product name
3-Hydroxybenzoic Acid
Purity
>98.0%(HPLC)(T)
Packaging
100g
Price
$49
Updated
2024/03/01
Alfa Aesar
Product number
A13628
Product name
3-Hydroxybenzoic acid, 99%
Packaging
100g
Price
$54.9
Updated
2024/03/01
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3-Hydroxybenzoic acid Chemical Properties,Usage,Production

Chemical Properties

White to light yellow crystal powder. 3-Hydroxybenzoic acid does not undergo decarboxylation at elevated temperature and is stable up to 300℃. This is in contrast to 2- and 4-hydroxybenzoic acids. Electrophilic substitution (e.g., nitration, halogenation, sulfonation) occurs ortho or para to the hydroxyl group. Thus, nitration with 62 % aqueous nitric acid gives 2-nitro-3-hydroxybenzoic acid as the main product, along with 4-nitro- and 6-nitro-3-hydroxybenzoic acids.

Uses

3-Hydroxybenzoic acid is used as an intermediate in the manufacture of germicides, plasticizers, preservatives, light stabiliziers, petroleum additives, pharmaceuticals, and plasticizer. It can also be used for the synthesis of azo dyes and herbicide fomesafen.

Definition

ChEBI: 3-hydroxybenzoic acid is a monohydroxybenzoic acid that is benzoic acid substituted by a hydroxy group at position 3. It has been isolated from Taxus baccata. It is used as an intermediate in the synthesis of plasticisers, resins, pharmaceuticals, etc. It has a role as a bacterial metabolite and a plant metabolite. It derives from a benzoic acid. It is a conjugate acid of a 3-hydroxybenzoate.

Application

3-Hydroxybenzoic acid is used in perfumery. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.

Preparation

3-Hydroxybenzoic acid is synthesized from benzoic acid by sulfonation, alkali melting and hydrolysis.
122kg of benzoic acid was put into the reactor, and 100kg of oleum was added under stirring. The temperature was raised to about 100 °C, and the reaction was carried out for 2h to obtain Sodium 3-sulfobenzoate. Then the sulfonated liquid was transferred to an alkali melting pot, 45 kg of solid sodium hydroxide was added, the temperature was raised to melting, and reacted for 4 to 5 hours to obtain sodium m-carboxyphenate, and diluted sulfuric acid was added for acid hydrolysis. Cool and crystallize, filter out sodium sulfate, and decolorize the filter cake with activated carbon to obtain 3-Hydroxybenzoic acid.

Reactions

m-Hydroxybenzoic Acid, of the three hydroxybenzoic acids, the metaisomer is of least commercial importance. Unlike salicylic acid, m-hydroxybenzoic acid does not undergo the Friedel-Crafts reaction. It can be converted in 80% yield to m-aminophenol by the Schmidt reaction, which involves treating the acid with hydrazoic acid in trichloroethylene in the presence of sulfuric acid at 40 °C.

Synthesis Reference(s)

Tetrahedron Letters, 9, p. 3845, 1968 DOI: 10.1016/S0040-4039(01)99116-6

Purification Methods

Crystallise the hydroxyacid from absolute EtOH. [Beilstein 10 IV 315.]

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3-Hydroxybenzoic acid Suppliers

TAIZHOU HAIYING PHARMTECH CO.,LTD
Tel
0523-0523-86222516 13382003766
Email
sales@haiyingchem.com
Country
China
ProdList
36
Advantage
58
Shanghai Kaisai Chemical Co., Ltd
Tel
021-33516722 13701817765
Fax
021-33516776
Email
kaisaichem@163.com
Country
China
ProdList
4741
Advantage
58
shanghai science Bio-Pharmceutical.co,ltd.
Tel
021-021-57872719 13761402923
Fax
02157872719
Email
245662540@qq.com
Country
China
ProdList
309
Advantage
60
Nanjing Yingkun Chemical Co., Ltd
Tel
025-83212803 13382003766
Email
sales@yingkunchem.cn
Country
China
ProdList
30
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820 13031183356
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1390
Advantage
62
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View Lastest Price from 3-Hydroxybenzoic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
3-Hydroxybenzoic acid 99-06-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-25
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
3-Hydroxybenzoic acid 99-06-9
Price
US $50.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-04-30
Jinan Finer Chemical Co., Ltd
Product
3-Hydroxybenzoic acid 99-06-9
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
300mt/year
Release date
2021-07-28

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