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Sasapyrine

Product Name
Sasapyrine
CAS No.
552-94-3
Chemical Name
Sasapyrine
Synonyms
Salina;diagen;Salysal;Disalyl;Nobacid;Salical;salflex;Saloxium;salgesic;salsitab
CBNumber
CB1240724
Molecular Formula
C14H10O5
Formula Weight
258.23
MOL File
552-94-3.mol
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Sasapyrine Property

Melting point:
139-151 °C
Boiling point:
361.48°C (rough estimate)
Density 
1.3326 (rough estimate)
refractive index 
1.4825 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: ≥15mg/mL
pka
pKa 3.5 (Uncertain);9.8 (Uncertain)
form 
Crystalline Powder
color 
white to tan
Water Solubility 
HYDROLYSIS
Sensitive 
Moisture Sensitive
Merck 
14,8339
CAS DataBase Reference
552-94-3
NIST Chemistry Reference
2-Carboxyphenyl salicylate(552-94-3)
EPA Substance Registry System
Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester (552-94-3)
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Safety

Hazard Codes 
Xi,N,Xn
Risk Statements 
36/37/38-50-22
Safety Statements 
37/39-26-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
DH2080000
TSCA 
Yes
HS Code 
29182300
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1941
Product name
Salsalate (Aspirin Impurity E)
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
200mg
Price
$256
Updated
2021/03/22
Sigma-Aldrich
Product number
1609807
Product name
Salsalate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
150mg
Price
$366
Updated
2021/03/22
TCI Chemical
Product number
S0129
Product name
2-Carboxyphenyl Salicylate
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$23
Updated
2021/03/22
TCI Chemical
Product number
S0129
Product name
2-Carboxyphenyl Salicylate
Purity
>98.0%(HPLC)(T)
Packaging
100g
Price
$50
Updated
2021/03/22
Alfa Aesar
Product number
B22444
Product name
Salicylsalicylic acid, 98%
Packaging
25g
Price
$53.7
Updated
2021/03/22
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Sasapyrine Chemical Properties,Usage,Production

Description

Salsalate, or salicylsalicylic acid, (pKa 3.5 [COOH], 9.8 [AR-OH]) is a dimer of salicylic acid. It is insoluble in gastric juice but is soluble in the small intestine, where it is partially hydrolyzed to two molecules of salicylic acid and absorbed. On a molar basis, it produces 15% less salicylic acid than aspirin. It does not cause GI blood loss and can be given to aspirin-sensitive patients. Salsalate is available as capsules and tablets.

Chemical Properties

white crystalline powder

Uses

Nonacetylated aspirin analog. Analgesic, anti-inflammatory.

Uses

Nonacetylated (e.g., sodium salicylate) and acetylated (aspirin) forms of salicylate are widely used to target inflammation in the treatment of insulin resistance, type 2 diabetes, or rheumatic pain. Sasapyrine is a dimeric prodrug comprising two esterified salicylate moieties. It is advantageous over sodium salicylate because it is insoluble at the acid pH of the stomach and passes suspended but undissolved into the small intestine, sparing the gastric mucosa direct contact.

Definition

ChEBI: A dimeric benzoate ester obtained by intermolecular condensation between the carboxy of one molecule of salicylic acid with the phenol group of a second. It is a prodrug for salycylic acid that is used for treatment of rheumatoid arthritis and osteoarthrit s and also shows activity against type II diabetes.

brand name

Disalcid (3M Pharmaceuticals).

General Description

Salsalate, salicylsalicylic acid (Amigesic, Disalcid,Salflex), is the ester formed between two salicylic acidmolecules. It is rapidly hydrolyzed to salicylic acid followingits absorption. It reportedly causes less gastric irritationthan aspirin, because it is relatively insoluble inthe stomach and is not absorbed until it reaches the smallintestine.

Sasapyrine Preparation Products And Raw materials

Raw materials

Preparation Products

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Sasapyrine Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2346
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43503
Advantage
61
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
9917
Advantage
62
Adamas Reagent, Ltd.
Tel
400-600-9262
Email
bxy@titansci.com
Country
China
ProdList
13915
Advantage
59
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-2580635- ;0712-2580635
Email
1791901229@qq.com;1791901229@qq.com;
Country
China
ProdList
8935
Advantage
52
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View Lastest Price from Sasapyrine manufacturers

Hebei Crovell Biotech Co Ltd
Product
Sasapyrine 552-94-3
Price
US $1.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 ton
Release date
2021-09-03
Zhuozhou Wenxi import and Export Co., Ltd
Product
Sasapyrine 552-94-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Shaanxi Dideu Medichem Co. Ltd
Product
Sasapyrine 552-94-3
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-29

552-94-3, SasapyrineRelated Search:


  • salicylicacid,bimolecularester
  • Salicyloxysalicylic acid
  • Salicyloylsalicylic acid
  • salicyloylsalicylicacid
  • Salicyl-salicylate
  • Salina
  • Saloxium
  • Salysal
  • Sasapirin
  • Sasapyrin
  • Sasapyrinum
  • disalicylicacid
  • Disalyl
  • Nobacid
  • NSC-49171
  • Sal Ester Sal
  • Salical
  • Salicylic acid, bimolecular ester
  • Salicylic acid, bimol. ester
  • Salicylic acid 2-carboxyphenyl
  • Salicylsalicylic acid,99%
  • Salsalate (150 mg)
  • Salsalate (125 mg)
  • Double salicylate
  • 2-Salicyloyloxybenzoic Acid O-Salicyloylsalicylic Acid Salicylic Acid 2-Carboxyphenyl Ester Salsalate
  • Aspirin EP IMpurity E
  • Aspirin IMpurity E
  • 2-[(2-hydroxyphenyl)carbonyloxy]benzoic acid
  • Acetylsalicylic Acid IMpurity E (Aspirin IMpurity E)
  • Sasapyrine Solution, 100ppm
  • Acetylsalicylic Acid EP Impurity E
  • Acetylsalicylic Acid Impurity 5(Acetylsalicylic Acid EP Impurity E)
  • O-SALICYLOYLSALICYLIC ACID
  • O-SALICYLSALICYLIC ACID
  • mono-gesic
  • salflex
  • salgesic
  • SALICYLSALICYLIC ACID
  • SALICYLIC ACID SALICYLATE
  • salicylylsalicylic acid
  • TIMTEC-BB SBB003097
  • SASAPYRINE
  • salsitab
  • SALSALATE
  • Arcylate
  • SALSALATE USP XXIV
  • SALICYLSALICYLIC ACID 99%
  • Salicylsalicylicacid,98%
  • disalcid
  • DISALICYLIC ACID, SALSALATE
  • diagen
  • 2-HYDROXYBENZOIC ACID 2-CARBOXYPHENYL ESTER
  • 2-CARBOXYPHENYL SALICYLATE
  • 2-SALICYLOYLOXYBENZOIC ACID
  • 2-salicylsalicylic acid
  • amigesic
  • 2-[(2-Hydroxybenzoyl)oxy]benzoic acid
  • 2-hydroxy-benzoicaci2-carboxyphenylester