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Phenyl salicylate

Description References
Product Name
Phenyl salicylate
CAS No.
118-55-8
Chemical Name
Phenyl salicylate
Synonyms
SALOL;Musol;FEMA 3960;Salphenyl;Seesorb 201;'LGC' (2411);'LGC' (2613);Phenyl salicy;Seesorb K 201;AURORA KA-3673
CBNumber
CB9322550
Molecular Formula
C13H10O3
Formula Weight
214.22
MOL File
118-55-8.mol
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Phenyl salicylate Property

Melting point:
41-43 °C (lit.)
Boiling point:
172-173 °C/12 mmHg (lit.)
Density 
1.250g/cm3
FEMA 
3960 | PHENYL SALICYLATE
refractive index 
1.5090 (estimate)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
dioxane: 0.1 g/mL, clear, colorless
pka
8.71±0.10(Predicted)
form 
Fine Crystalline Powder
color 
White
Water Solubility 
Soluble in alcohol, ether, chloroform, turpentine, acetone and benzene. Sparingly soluble in chloroformbenzene. Insoluble in water.
Merck 
14,7310
JECFA Number
736
BRN 
393969
Stability:
Light sensitive. Incompatible with strong oxidants. Flammable.
CAS DataBase Reference
118-55-8(CAS DataBase Reference)
NIST Chemistry Reference
Benzoic acid, 2-hydroxy-, phenyl ester(118-55-8)
EPA Substance Registry System
Phenyl salicylate (118-55-8)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
2
RTECS 
VO6125000
TSCA 
Yes
HS Code 
29182300
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
149187
Product name
Phenyl salicylate
Purity
ReagentPlus , 99%
Packaging
50g
Price
$49.4
Updated
2021/03/22
Sigma-Aldrich
Product number
149187
Product name
Phenyl salicylate
Purity
ReagentPlus , 99%
Packaging
250g
Price
$55
Updated
2021/03/22
TCI Chemical
Product number
S0017
Product name
Phenyl Salicylate
Purity
>98.0%(GC)
Packaging
25g
Price
$24
Updated
2021/03/22
TCI Chemical
Product number
S0017
Product name
Phenyl Salicylate
Purity
>98.0%(GC)
Packaging
500g
Price
$90
Updated
2021/03/22
Alfa Aesar
Product number
B20686
Product name
Phenyl salicylate, 99%
Packaging
100g
Price
$27
Updated
2021/03/22
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Phenyl salicylate Chemical Properties,Usage,Production

Description

Phenyl salicylate (chemical formula: C13H10O3) belongs to the family of hydroxybenzoic acid which are compound containing a hydroxybenzoic acid or its derivative. It is manufactured through the chemical reaction between phenol and salicylic acid. Phenyl salicylate has several medical properties. It can be used as analgesic to relieve pain, as an antiseptic with antibacterial effect as well as a kind of antipyretic for the treatment of fever. It is also used for the treatment of inflammation triggered by the lower urinary tract. However, it is no longer commonly applied to human medicine, but is still used in veterinary medicine.

References

https://pubchem.ncbi.nlm.nih.gov/compound/Phenyl_salicylate#section=Top
http://www.wisegeek.com/what-are-the-medical-uses-of-phenyl-salicylate.htm

Chemical Properties

white crystalline solid with an aromatic odour

Chemical Properties

Phenyl salicylate has a distinctive aromatic odor and taste.

Occurrence

Has apparently not been reported to occur in nature.

Uses

Phenyl salicylate is used as an analgesic and antipyretic. It is also used in the manufacture of polymer plastics, lacquers, waxes, polishes, adhesives, and sunscreen products. It is also a fragrance ingredient, but has limited use.

Uses

In the manufacture of various polymers for the plastics industry, also in lacquers, adhesives, waxes, polishes. In suntan oils and cremes. As light absorber to prevent discoloration of plastics. Has some plasticizer properties.

Uses

Phenyl salicylate is used as analgesie; antipyretie; anti-rheumatie agent; manufacture of polymer plastics, lacquers, waxes, polishes, and adhesives; in suntan oils and creams; light absorber to prevent discoloration of plastics; in veterinary use as an external disinfectant and intestinal antiseptic agent.

Definition

ChEBI: A benzoate ester that is the phenyl ester of salicylic acid. Also known as salol, it can be formed by heating salicylic acid with phenol and is used in the manufacture of some polymers, lacquers, adhesives, waxes and polishes.

Preparation

By the action of phosphorus oxychloride on a mixture of phenol and salicylic acid (Merck Index, 1968).

Toxicity evaluation

The acute oral LD50 value in rats was reported as 3 g/kg and the acute dermal LD50 value in rabbits exceeded 5 g/kg (Levenstein, 1975). The probable LD in man is 50-500 mg/kg. The toxic effects of phenyl salicylate are similar to those of phenol but do not include a corrosive action on the alimentary canal (Dittmer, 1959).

General Description

White crystals. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Incompatible with bromine water, ferric salts, camphor, phenol, chloral hydrate, monobrominated camphor, thymol, or urethane in trituration. .

Fire Hazard

Flash point data for Phenyl salicylate are not available, however Phenyl salicylate is probably combustible.

Pharmacology

Phenyl salicylate was found to have slight analgesic activity against pain stimuli in mice (Kameyama, 1961), but ip administration of 500 mg/kg showed no analgesic action against an electric shock applied to the tails of mice (McKenzie & Beechey, 1962). In vitro studies on cartilage and rat-liver mitochondria have shown that phenyl salicylates are more active than salicylates in uncoupling oxidative phosphorylation (Bostrom, Berntsen & Whitehouse, 1964).

Safety Profile

Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTERS

Chemical Synthesis

Prepared by a synthetic process whereby the phenol group is made to unite with the salicylic acid radical. Also obtained by heating salicylic acid, the air being excluded.

Metabolism

According to Baas (1890) from 44 to 96% of a dose (5-8 g) of phenyl salicylate is hydrolysed in man and none of it is found in the faeces. An increase in the ethereal sulphates of the urine after its ingestion is due, no doubt, to the phenol liberated (Williams, 1959). Phenyl salicylate is hydrolysed in the gut primarily to phenol and salicylic acid, which are rapidly absorbed and excreted (Fassett, 1963), but it was not hydrolysed by a partially purified preparation of acetylarylesterase from human plasma (Augustinsson & Ekedahl, 1962). Intestinal absorption and excretion of orally administered phenyl salicylate were studied in rabbits and dogs by analysis of blood and urine samples; oral administration of glucosamine hydrochloride increased the blood concentration of phenyl salicylate but had little effect on urinary excretion (Tanaka, Kojima & Matsubara, 1961).

Purification Methods

Fractionally crystallise salol from its melt, then crystallise it from *benzene. [Beilstein 10 IV 154.]

Phenyl salicylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Phenyl salicylate Suppliers

HUBEI RISON CHEMICAL CO.,LTD
Tel
027 83642615 13995607107
Fax
027 83660699
Email
market@risonchem.com
Country
China
ProdList
281
Advantage
58
Hangzhou chemfluoro Chemical Co., Ltd.
Tel
0571-86780539
Fax
0571-86780539
Email
chemfluoro@126.com
Country
China
ProdList
24
Advantage
58
Jinan MaoFuYi Chemical Co., Ltd.
Tel
0531-88996911
Fax
0531-88996911 QQ:3305202763
Email
3305202763@qq.com
Country
China
ProdList
51
Advantage
58
Shenzhen noadia chemical technology co., ltd
Email
2880680559@qq.com
Country
China
ProdList
37
Advantage
58
Shanghai jiubang chemical co., ltd
Tel
Fax
021-66315995
Email
jiubang_168@163.com
Country
China
ProdList
30
Advantage
58
Wuhan Yuqing Jiaheng Pharmaceutical Co., Ltd.
Tel
027-83850122-
Email
918571372@qq.com
Country
China
ProdList
986
Advantage
58
Henan Huawen Chemical Co., Ltd
Tel
0370-2070108-
Fax
QQ:2712427897
Email
2712427897@qq.com
Country
China
ProdList
8899
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
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View Lastest Price from Phenyl salicylate manufacturers

Wuhan wingroup Pharmaceutical Co., Ltd
Product
Phenyl salicylate 118-55-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2021-07-09
Guangzhou Sunton Biotechnology Co., Ltd.
Product
Phenyl salicylate 118-55-8
Price
US $48.00-40.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200tons
Release date
2021-06-08
Hebei Senko Biotechnology Co., Ltd.
Product
Phenyl salicylate 118-55-8
Price
US $10.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
10 Tons
Release date
2021-07-23

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