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Diphenyl ether

Product Name
Diphenyl ether
CAS No.
101-84-8
Chemical Name
Diphenyl ether
Synonyms
DIPHENYL OXIDE;Oxydibenzene;PHENYL ETHER;PHENOXYBENZENE;Biphenyl oxide;Phenyl oxide;ether,diphenyl;FEMA 3667;NSC 19311;AKOS 90362
CBNumber
CB4852610
Molecular Formula
C12H10O
Formula Weight
170.21
MOL File
101-84-8.mol
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Diphenyl ether Property

Melting point:
26 °C
Boiling point:
259 °C(lit.)
Density 
1.073 g/mL at 25 °C(lit.)
vapor density 
>5.86 (25 °C, vs air)
vapor pressure 
<1 mm Hg ( 20 °C)
refractive index 
n20/D 1.579(lit.)
FEMA 
3667 | DIPHENYL ETHER
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
alcohol: soluble(lit.)
form 
Colorless liquid
color 
White or Colorless to Almost white or Almost colorless
Specific Gravity
1.073
Relative polarity
2.8
Odor
Weak geranium.
Odor Threshold
0.1ppm
Odor Type
green
explosive limit
0.8-1.5%(V)
Water Solubility 
insoluble
FreezingPoint 
27℃
Merck 
14,7288
JECFA Number
1255
BRN 
1364620
Henry's Law Constant
2.13 at 20 °C (approximate - calculated from water solubility and vapor pressure)
Exposure limits
NIOSH REL: TWA 1 ppm (7 mg/m3), IDLH 100 ppm; OSHA PEL: TWA 1 ppm; ACGIH TLV: TWA 0.1, STEL 2 ppm (adopted).
Dielectric constant
3.7(30℃)
InChIKey
USIUVYZYUHIAEV-UHFFFAOYSA-N
LogP
4.21 at 25℃
CAS DataBase Reference
101-84-8(CAS DataBase Reference)
NIST Chemistry Reference
Diphenyl ether(101-84-8)
EPA Substance Registry System
Phenyl ether (101-84-8)
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Safety

Hazard Codes 
N,Xi,T
Risk Statements 
51/53-36/37/38-39/23/24/25-23/24/25-36/38-36
Safety Statements 
60-61-57-37/39-26-45-36/37
RIDADR 
UN 3077 9/PG 3
OEB
B
OEL
TWA: 1 ppm (7 mg/m3)
WGK Germany 
2
RTECS 
KN8970000
Autoignition Temperature
610 °C
TSCA 
Yes
HS Code 
2909 30 10
HazardClass 
9
PackingGroup 
III
Hazardous Substances Data
101-84-8(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 2450 mg/kg LD50 dermal Rabbit > 7940 mg/kg
IDLA
100 ppm
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W366706
Product name
Diphenyl ether
Purity
≥99%, FG
Packaging
1kg
Price
$76.5
Updated
2024/03/01
Sigma-Aldrich
Product number
W366706
Product name
Diphenyl ether
Purity
≥99%, FG
Packaging
25kg
Price
$364.2
Updated
2024/03/01
Sigma-Aldrich
Product number
W366706
Product name
Diphenyl ether
Purity
≥99%, FG
Packaging
10Kg
Price
$401
Updated
2024/03/01
Sigma-Aldrich
Product number
8.20978
Product name
Diphenyl ether
Purity
for synthesis
Packaging
100mL
Price
$44.2
Updated
2024/03/01
Sigma-Aldrich
Product number
8.20978
Product name
Diphenyl ether
Purity
for synthesis
Packaging
1L
Price
$66.2
Updated
2024/03/01
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Diphenyl ether Chemical Properties,Usage,Production

Description

Diphenyl ether (diphenyl oxide) is a colorless liquid with a floral odor. It is a white, crystalline solid at temperatures below 80ºF (27ºC). It has low volatility, low solubility in water, and is stable at high temperatures. Avoid contact with oxidizing materials.
Liquid diphenyl oxide is used primarily in industry. It is used in the industrial setting as a heat transfer fluid. It is the major component of Dowtherm A® (an eutectic mixture of phenyl ether and biphenyl) and further as a chemical intermediate in the production of surface-active agents and hightemperature lubricants, and in perfumery due to its geranium-like odour (ACG99b). It is also used as a chemical intermediate in the manufacture of surfactants and fire retardants.
Diphenyl oxide (DPO) is manufactured using the direct phenol method.

Physical properties

Diphenyl oxide is a practically colorless crystalline solid with a harsh, floral-green, metallic geranium-type odor. clear pale yellowish liquid after melting. It is almost completely insoluble in water, but dissolves in most of the common organic solvents. Its high thermal stability at temperatures as high as 350 to 400°C. together with its noncorrosiveness and general chemical inertness make it eminently suitable as a component of high-boiling heat transfer media.

Chemical Properties

Diphenyl Ether has not been observed in nature. It is a colorless liquid or a crystalline solid (mp 26.8°C) with an odor reminiscent of geranium leaves. Diphenyl ether is obtained as a by-product in the production of phenol by high-pressure hydrolysis of chlorobenzene. Because of its stability and low price, diphenyl ether is used in large quantities in soap perfumes.

Occurrence

Reported found in muscat grapes, grilled beef, green tea, potato chips, buckwheat, Bourbon vanilla and lemon balm.

Uses

Diphenyl ether is widely used as a heat transfer agent and a dye carrier. It can be used alone or as a mixture with other materials. Because of its reactivity, It can also be used as a raw material or chemical intermediate to produce commercial products. Diphenyl ether is used in the production of:

  1. Diphenyl ether is employed as a processing aid in the production of polyesters. It acts as a chemical intermediate in the production of surface active agents and high temperature lubricants, fire retardants like polybrominated diphenyl ethers (PBDEs) and fragrance for detergents.
  2. Heat transfer media – like DOWTHERMTM fluids used for heating industrial processes
  3. Alkylated diphenyl oxides – used to make surfactants, greases and lubricants
  4. Halogenated diphenyl oxides – used in insecticides, wood preservatives, and flame retardants for appliance casings in consumer electronic products
  5. High temperature solvents
  6. Coatings
  7. Textile dye labeling
  8. Plastics – like ethylene-propylene-diene monomer (EPDM) rubber that is used for membrane roofing materials
  9. Diphenyl ether plays a vital role in the Ferrario reaction to produce phenoxathiin, which finds application in polyamide and polyimide production. Involving similar reactions, diphenyl ether is a significant side product in the high-pressure hydrolysis of chlorobenzene in the production of phenol.
  10. Diphenyl ether is found in alcoholic beverages. Diphenyl ether is present in muscat grapes, green tea, vanilla, lemon balm, buckwheat, potato chips and grilled beef. Diphenyl ether is a flavouring ingredient.

Uses

Phenyl Ether is an Impurity of Propofol (P829750).

Definition

ChEBI: Diphenyl ether is an aromatic ether in which the oxygen is attached to two phenyl substituents. It has been found in muscat grapes and vanilla. It has a role as a plant metabolite.

Preparation

By heating potassium phenolate with bromobenzene or with chlorobenzene at elevated temperatures.

Aroma threshold values

Aroma characteristics at 1.0%: grassy, musty, powdery, dry, terpy, ocimenelike, aromatic and hoplike with green juniper berry nuances.

Taste threshold values

Taste characteristics at 10 ppm: dry chemical, floral rosey with carrot, tropical and hoplike terpy notes and a green vegetative and woody nuance.

Synthesis Reference(s)

Synthetic Communications, 13, p. 335, 1983 DOI: 10.1080/00397918308066985
Synthesis, p. 204, 1991 DOI: 10.1055/s-1991-26419

General Description

Diphenyl ether occurs, e.g., in lemon balm oil. The compound forms colorless crystals that possess a geranium-like aroma. Diphenyl ether is formed as a byproduct in the high-pressure hydrolysis of chlorobenzene. Because of its high thermal stability, a eutectic mixture of diphenyl ether and biphenyl is employed as a heat transfer medium. Diphenyl ether is the starting material for organic intermediates and is used as a fragrance component. The compound is also employed as a processing aid in the production of polyesters; several polybromine derivatives of diphenyl ether are used as fire retardants.

General Description

Colorless liquid with a mild pleasant odor. May float or sink in water. Freezing point is 81°F.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Diphenyl oxide can react with oxidizing materials. . A vigorous reaction occurred between the ether and chlorosulfuric acid.

Health Hazard

Inhalation may cause nausea because of disagreeable odor. Contact of liquid with eyes causes mild irritation. Prolonged exposure of skin to liquid causes reddening and irritation. Ingestion produces nausea.

Fire Hazard

Diphenyl oxide is combustible.

Flammability and Explosibility

Non flammable

Safety Profile

Moderately toxic by ingestion. Prolonged exposure damages liver, spleen, kidneys, and thyroid, and upsets gastrointestinal tract. A skin and eye irritant. Combustible when exposed to heat or flame; can react with oxidizing materials. For explosion hazard, see ETHERS. To fight fire, use water, foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes

Potential Exposure

Strong oxidizers may cause fire andexplosions. Attacks some plastics, rubber, and coatings.

First aid

Wear protective gloves andclothing to prevent any reasonable probability of skin contact. Safety equipment suppliers/manufacturers can providerecommendations on the most protective glove/clothingmaterial for your operation. All protective clothing (suits,gloves, footwear, headgear) should be clean, available eachday, and put on before work. Contact lenses should not beworn when working with this chemical. Wear splash-proofgoggles and face shield if working with the liquid or dustproof chemical goggles and face shield if working with thecrystalline material, unless full face-piece respiratory protection is worn. Employees should wash immediately withsoap when skin is wet or contaminated. Provide emergencyshowers and eyewash.Respirator Selection: 2

Carcinogenicity

Phenyl ether was not mutagenic in the Ames Salmonella assay with or without metabolic activation.

storage

Color Code—Green: General storage may be used.Prior to working with diphenyl oxide you should be trainedon its proper handling and storage. Before entering confinedspace where this chemical may be present, check to makesure that an explosive concentration does not exist. Store intightly closed containers in a cool, well-ventilated areaaway from oxidizers. Store in tightly closed containers in acool, well-ventilated area away from heat. Sources of ignition, such as smoking and open flames, are prohibitedwhere this chemical is used, handled, or stored in a mannerthat could create a potential fire or explosion hazard. Metalcontainers involving the transfer of 5 gallons or more ofthis chemical should be grounded and bonded. Drums mustbe equipped with self-closing valves, pressure vacuumbungs, and flame arresters. Use only nonsparking tools andequipment, especially when opening and closing containersof this chemical.

Shipping

The name of this material is not in the DOT listof materials for label and packaging standards. However,based on regulations, it may be classified as anEnvironmentally hazardous substances, solid, n.o.s. Thischemical requires a shipping label of “CLASS 9.” It falls inHazard Class 9 and Packing Group III.[20,

Purification Methods

Crystallise the ether from 90% EtOH. Melt it, wash it with 3M NaOH and water, dry it with CaCl2 and fractionally distil it under reduced pressure. Fractionally recrystallise it from its melt and store over P2O5. [Beilstein 6 IV 562.]

Diphenyl ether Preparation Products And Raw materials

Raw materials

Preparation Products

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Diphenyl ether Suppliers

LGC Science (Shanghai) Ltd.
Tel
17717235263
Email
cindy.yang@lgcgroup.com
Country
China
ProdList
11657
Advantage
58
Shanghai Ronghe Chemical Co. , Ltd.
Tel
18766949288
Email
276744338@qq.com
Country
China
ProdList
122
Advantage
58
Zibo Junlida Chemical Co. , Ltd.
Tel
18560270963
Email
1258536883@qq.com
Country
China
ProdList
367
Advantage
58
Shanghai RC Chemicals Co. Ltd
Tel
17305617782 17305617782
Fax
86-21-50322176
Email
sales1@rcc.net.cn
Country
China
ProdList
344
Advantage
55
Hubei Guangao Biotechnology Co., Ltd
Tel
027-027-59223056 18162699093
Fax
027-59223056
Email
1208480011@qq.com
Country
China
ProdList
9924
Advantage
58
Guangzhou Dreampharm Biotechnology Co., Ltd.
Tel
020-36607679 17825480238
Fax
QQ 3008233717
Email
3008233717@qq.com
Country
China
ProdList
9919
Advantage
12
Shanghai Aoguang Biotechnology Co., Ltd
Tel
1735-4997695 17715859063
Email
1204996172@qq.com
Country
China
ProdList
230
Advantage
58
Shanghai Yiji Chemical Co.,Ltd.
Tel
021-22810390-339 13916710504
Email
421877690@qq.com
Country
China
ProdList
18
Advantage
58
Jobachem Suzhou Co., Ltd
Tel
0512-62927368; 18136961057
Email
min.li@jobachem.com
Country
China
ProdList
51
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
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View Lastest Price from Diphenyl ether manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Diphenyl oxide 101-84-8
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5ton
Release date
2024-04-28
Hebei Chuanghai Biotechnology Co,.LTD
Product
Diphenyl oxide 101-84-8
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-19
Baoji Guokang Bio-Technology Co., Ltd.
Product
Diphenyl ether 101-84-8
Price
US $5.00/KG
Min. Order
250KG
Purity
99%
Supply Ability
20T
Release date
2021-06-03

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