2-Piperazinone

Product Name: 2-Piperazinone
CAS No.: 5625-67-2
Chemical Name: 2-Piperazinone
Synonyms: PIPERAZIN-2-ONE;2-OXOPIPERAZINE;PIPERAZINE-2-ONE;PIPERAZINONE;NSC 27441;AKOS BBB/413;PIPERBORNENE;2-piperadone;2-piperazone;2-Piperzinone
CBNumber: CB3487176
Molecular Formula: C4H8N2O
Formula Weight: 100.12
MOL File: 5625-67-2.mol

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2-Piperazinone Property

Melting point:: 136-140 °C (lit.)
Boiling point:: 164°C/5mmHg(lit.)
Density: 1.053±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform
form: Crystalline Powder
pka: 15.47±0.20(Predicted)
color: White to tan
Sensitive: Hygroscopic
Stability:: Stable, but may be light and moisture sensitive. Incompatible with oxidizing agents.
InChI: InChI=1S/C4H8N2O/c7-4-3-5-1-2-6-4/h5H,1-3H2,(H,6,7)
InChIKey: IWELDVXSEVIIGI-UHFFFAOYSA-N
SMILES: N1CCNCC1=O
CAS DataBase Reference: 5625-67-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-43
Safety Statements: 26-36/37
RIDADR: 1759
WGK Germany: 3
HazardClass: 8
PackingGroup: III
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 641065
Product name: 2-Oxopiperazine
Purity: 97%
Packaging: 1g
Price: $30.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 641065
Product name: 2-Oxopiperazine
Purity: 97%
Packaging: 5g
Price: $105
Updated: 2025/07/31

TCI Chemical

Product number: P1867
Product name: 2-Piperazinone
Purity: >98.0%(GC)
Packaging: 1g
Price: $23
Updated: 2025/07/31

TCI Chemical

Product number: P1867
Product name: 2-Piperazinone
Purity: >98.0%(GC)
Packaging: 5g
Price: $67
Updated: 2025/07/31

TRC

Product number: P480140
Product name: 2-Piperazinone
Packaging: 2g
Price: $110
Updated: 2021/12/16

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2-Piperazinone Chemical Properties,Usage,Production

Chemical Properties

solid

Uses

2-Piperazinone (cas# 5625-67-2) is a compound useful in organic synthesis.

Definition

ChEBI: Piperazine-2-one is a carboximidic acid.

Synthesis

105-39-5

107-15-3

5625-67-2

The general procedure for the synthesis of 2-piperazinone from ethyl chloroacetate and ethylenediamine was as follows: ethyl chloroacetate (4.9 g, 40 mmol) was dissolved in 40 mL of anhydrous ethanol and slowly added dropwise to 100 mL of ethylenediamine (24 g, 400 mmol) over 3.5 hours at room temperature. After the dropwise addition, the reaction mixture was allowed to stand for 2 hours. Subsequently, sodium ethoxide (15 mL, 40 mmol, 21% w/w denatured ethanol solution) was added, the precipitated sodium chloride was removed by filtration and the solvent was evaporated. To the resulting red oil 40 mL of DMF was added and stirred at room temperature for 24 h. The mixture was then heated at 60°C to 70°C while N2 gas was passed through to remove volatiles. The resulting yellow solid was separated by silica gel column chromatography, eluting using a solvent mixture (CHCl3:MeOH:NH4OH = 9:1:0.1) to give the crude product (3.3 g, 33 mmol, 82% yield). This yellow solid was used directly in the next step of the reaction without further purification. Pure white crystals were obtained by three times recrystallization from acetone.1H NMR (CDCl3): δ 1.70 (1H, br s), 3.03 (2H, t, J = 5.4 Hz), 3.37 (2H, td, J = 2.3, 5.4 Hz), 3.52 (2H, s), 6.54 (1H, br s).13C NMR (CDCl3): δ 42.31, 43.05, 49.83, 170.00. melting point: 132°C-134°C (uncorrected) [literature value: 136°C (corrected)] (American Chemical Society Journal, 62 (1940) 1202-1204).

References

[1] Patent: US2005/222166, 2005, A1. Location in patent: Page/Page column 13
[2] Tetrahedron Letters, 1994, vol. 35, # 51, p. 9545 - 9548
[3] Patent: WO2006/51851, 2006, A1. Location in patent: Page/Page column 80
[4] Journal of the American Chemical Society, 1940, vol. 62, p. 1202

2-Piperazinone Preparation Products And Raw materials

Raw materials

Ethylenediamine Ethanol Diphenyl ether Sodium Sodium ethoxide Ethyl bromoacetate Ethyl acetate PETROLEUM ETHER Ethyl chloroacetate

Preparation Products

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2-Piperazinone Suppliers

Americas 1 Belgium 1 Canada 3 China 274 Europe 1 France 2 Germany 8 India 21 Japan 3 Lithuania 1 Russia 3 Switzerland 5 Ukraine 3 United Kingdom 18 United States 50 Global 394

Hangzhou Disynthesis Chemical Technology Co., Ltd.

Tel: +86-0571-88194596 15558156576
Fax: 0571-88199298
Email: sales@disynchem.com
Country: China
ProdList: 94
Advantage: 55

Shanghai Chainpharm Bio-medical Technology Co., Ltd.

Tel: +86-021-61727342 13611721451
Fax: 021-61294107
Email: chainpharm@163.com
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Shanghai GaoLang Chemical Technology Co., Ltd.

Tel: 021-57340939 18017297327
Fax: 021-37210791
Email: sales@gaolangchemical.com
Country: China
ProdList: 892
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Jinan Kabotang Biological Technology Co.,Ltd.

Tel: 0531-61320525 15866703830
Email: figo.gao@foxmail.com
Country: China
ProdList: 5178
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Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
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INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
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future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
Country: China
ProdList: 1995
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Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
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View Lastest Price from 2-Piperazinone manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Piperazinone 5625-67-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Piperazinone 5625-67-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-03-20

Hebei Ganmiao New material Technology Co., LTD

Product: 2-Piperazinone 5625-67-2
Price: US $10.00-7.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 20ton
Release date: 2024-06-06

5625-67-2, 2-PiperazinoneRelated Search:

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TIMTEC-BB SBB000034

PIPERAZINONE

PIPERAZIN-2-ONE

PIPERAZINE-2-ONE

2-PIPERAZINONE

2-OXOPIPERZAINE

2-OXOPIPERAZINE

AKOS BBS-00007028

AKOS BBB/413

CHEMBRDG-BB 4102110

2-Piperzinone

Piperazin-2-one, 99+%

PIPERBORNENE

Piperazin-2-one ,98%

2-piperadone

Piperazinone (8CI,9CI)

piperazin-2-one(SALTDATA: FREE)

2-Ketopiperazine

3-Oxopiperazine

NSC 27441

Oxopiperazine

Tetrahydro-2(1H)-pyrazinone

Piperazin-2-one 2-Oxopiperazine

pyrazin-2(3H)-one

2 - piperazine ketone

2-Oxopiperazine 97%

2-oxo-piperadzine

2-Piperazinone,97%

2-piperazone

2-Piperazinone&gt

2-Piperazinone ISO 9001：2015 REACH

Piperazin-2-one 2-Oxopiperazin

3-oxopiperazin-1-ium

Piperazin-2-one, Piperazine-2-one, 2-Oxopiperazine, 2-Piperazinone, Piperazinone

5625-67-2

5626-67-2

C4H9N2O

AMIDE

Building Blocks

Piperazines

Heterocyclic Building Blocks

Building Blocks

C4 to C8

Chemical Synthesis

Heterocyclic Building Blocks

Heterocycles

Miscellaneous Reagents

pharmacetical

Piperaizine

Ketone

Building Blocks

Heterocyclic Building Blocks

Piperazines

Non-Chiral heterocyclic compounds