ChemicalBook > CAS DataBase List > 2-Piperazinone

2-Piperazinone

Product Name
2-Piperazinone
CAS No.
5625-67-2
Chemical Name
2-Piperazinone
Synonyms
PIPERAZIN-2-ONE;2-OXOPIPERAZINE;PIPERAZINE-2-ONE;PIPERAZINONE;NSC 27441;AKOS BBB/413;PIPERBORNENE;2-piperadone;2-piperazone;2-Piperzinone
CBNumber
CB3487176
Molecular Formula
C4H8N2O
Formula Weight
100.12
MOL File
5625-67-2.mol
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2-Piperazinone Property

Melting point:
136-140 °C (lit.)
Boiling point:
164°C/5mmHg(lit.)
Density 
1.053±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform
form 
Crystalline Powder
pka
15.47±0.20(Predicted)
color 
White to tan
Sensitive 
Hygroscopic
Stability:
Stable, but may be light and moisture sensitive. Incompatible with oxidizing agents.
InChI
InChI=1S/C4H8N2O/c7-4-3-5-1-2-6-4/h5H,1-3H2,(H,6,7)
InChIKey
IWELDVXSEVIIGI-UHFFFAOYSA-N
SMILES
N1CCNCC1=O
CAS DataBase Reference
5625-67-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-43
Safety Statements 
26-36/37
RIDADR 
1759
WGK Germany 
3
HazardClass 
8
PackingGroup 
III
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
641065
Product name
2-Oxopiperazine
Purity
97%
Packaging
1g
Price
$30.5
Updated
2025/07/31
Sigma-Aldrich
Product number
641065
Product name
2-Oxopiperazine
Purity
97%
Packaging
5g
Price
$105
Updated
2025/07/31
TCI Chemical
Product number
P1867
Product name
2-Piperazinone
Purity
>98.0%(GC)
Packaging
1g
Price
$23
Updated
2025/07/31
TCI Chemical
Product number
P1867
Product name
2-Piperazinone
Purity
>98.0%(GC)
Packaging
5g
Price
$67
Updated
2025/07/31
TRC
Product number
P480140
Product name
2-Piperazinone
Packaging
2g
Price
$110
Updated
2021/12/16
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2-Piperazinone Chemical Properties,Usage,Production

Chemical Properties

solid

Uses

2-Piperazinone (cas# 5625-67-2) is a compound useful in organic synthesis.

Definition

ChEBI: Piperazine-2-one is a carboximidic acid.

Synthesis

105-39-5

107-15-3

5625-67-2

The general procedure for the synthesis of 2-piperazinone from ethyl chloroacetate and ethylenediamine was as follows: ethyl chloroacetate (4.9 g, 40 mmol) was dissolved in 40 mL of anhydrous ethanol and slowly added dropwise to 100 mL of ethylenediamine (24 g, 400 mmol) over 3.5 hours at room temperature. After the dropwise addition, the reaction mixture was allowed to stand for 2 hours. Subsequently, sodium ethoxide (15 mL, 40 mmol, 21% w/w denatured ethanol solution) was added, the precipitated sodium chloride was removed by filtration and the solvent was evaporated. To the resulting red oil 40 mL of DMF was added and stirred at room temperature for 24 h. The mixture was then heated at 60°C to 70°C while N2 gas was passed through to remove volatiles. The resulting yellow solid was separated by silica gel column chromatography, eluting using a solvent mixture (CHCl3:MeOH:NH4OH = 9:1:0.1) to give the crude product (3.3 g, 33 mmol, 82% yield). This yellow solid was used directly in the next step of the reaction without further purification. Pure white crystals were obtained by three times recrystallization from acetone.1H NMR (CDCl3): δ 1.70 (1H, br s), 3.03 (2H, t, J = 5.4 Hz), 3.37 (2H, td, J = 2.3, 5.4 Hz), 3.52 (2H, s), 6.54 (1H, br s).13C NMR (CDCl3): δ 42.31, 43.05, 49.83, 170.00. melting point: 132°C-134°C (uncorrected) [literature value: 136°C (corrected)] (American Chemical Society Journal, 62 (1940) 1202-1204).

References

[1] Patent: US2005/222166, 2005, A1. Location in patent: Page/Page column 13
[2] Tetrahedron Letters, 1994, vol. 35, # 51, p. 9545 - 9548
[3] Patent: WO2006/51851, 2006, A1. Location in patent: Page/Page column 80
[4] Journal of the American Chemical Society, 1940, vol. 62, p. 1202

2-Piperazinone Preparation Products And Raw materials

Raw materials

Ethylenediamine Ethanol Diphenyl ether Sodium Sodium ethoxide Ethyl bromoacetate Ethyl acetate PETROLEUM ETHER Ethyl chloroacetate

Preparation Products

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View Lastest Price from 2-Piperazinone manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-Piperazinone 5625-67-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Shaanxi Dideu New Materials Co. Ltd
Product
2-Piperazinone 5625-67-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-03-20
Hebei Ganmiao New material Technology Co., LTD
Product
2-Piperazinone 5625-67-2
Price
US $10.00-7.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
20ton
Release date
2024-06-06

5625-67-2, 2-PiperazinoneRelated Search:

Levodropropizine 2-Ethylhexyl ferulate Levodropropizine N-Aminoethylpiperazine Piperazine Piperacillin ETHYL 2-(3-OXO-2-PIPERAZINYL)ACETATE ALPHA-ERGOCRYPTINE DIHYDROERGOTAMINE TARTRATE SARCOSINE ANHYDRIDE N,N'-DIACETYLGLYCINE ANHYDRIDE (S)-3-Isopropyl-2,5-piperazinedione Bromocriptine mesylate Praziquantel DL-2-AMINOPROPIONIC ANHYDRIDE GLYCINE ANHYDRIDE Dihydroergotoxine 4-Ethyl-2,3-dioxo-1-piperazine carbonyl chloride

  • TIMTEC-BB SBB000034
  • PIPERAZINONE
  • PIPERAZIN-2-ONE
  • PIPERAZINE-2-ONE
  • 2-PIPERAZINONE
  • 2-OXOPIPERZAINE
  • 2-OXOPIPERAZINE
  • AKOS BBS-00007028
  • AKOS BBB/413
  • CHEMBRDG-BB 4102110
  • 2-Piperzinone
  • Piperazin-2-one, 99+%
  • PIPERBORNENE
  • Piperazin-2-one ,98%
  • 2-piperadone
  • Piperazinone (8CI,9CI)
  • piperazin-2-one(SALTDATA: FREE)
  • 2-Ketopiperazine
  • 3-Oxopiperazine
  • NSC 27441
  • Oxopiperazine
  • Tetrahydro-2(1H)-pyrazinone
  • Piperazin-2-one 2-Oxopiperazine
  • pyrazin-2(3H)-one
  • 2 - piperazine ketone
  • 2-Oxopiperazine 97%
  • 2-oxo-piperadzine
  • 2-Piperazinone,97%
  • 2-piperazone
  • 2-Piperazinone&gt
  • 2-Piperazinone ISO 9001：2015 REACH
  • Piperazin-2-one 2-Oxopiperazin
  • 3-oxopiperazin-1-ium
  • Piperazin-2-one, Piperazine-2-one, 2-Oxopiperazine, 2-Piperazinone, Piperazinone
  • 5625-67-2
  • 5626-67-2
  • C4H9N2O
  • AMIDE
  • Building Blocks
  • Piperazines
  • Heterocyclic Building Blocks
  • Building Blocks
  • C4 to C8
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Heterocycles
  • Miscellaneous Reagents
  • pharmacetical
  • Piperaizine
  • Ketone
  • Building Blocks
  • Heterocyclic Building Blocks
  • Piperazines
  • Non-Chiral heterocyclic compounds