α-Ergocryptine
- Product Name
- α-Ergocryptine
- CAS No.
- 511-09-1
- Chemical Name
- α-Ergocryptine
- Synonyms
- ergocryptine;ergokryptine;Ergocrypyine;Ergocriptine;A-ergocryptine;α-Ergocryptine;alpha-ergokryptine;9,10-Dihydro-βALPHA-ERGOCRYPTINE;ERGOCRYPTINE95%,98%
- CBNumber
- CB8205993
- Molecular Formula
- C32H41N5O5
- Formula Weight
- 575.7
- MOL File
- 511-09-1.mol
α-Ergocryptine Property
- Melting point:
- 152-154°C
- alpha
- D20 -120° (pyridine); -198° (chloroform)
- Boiling point:
- 636.59°C (rough estimate)
- Density
- 1.1762 (rough estimate)
- refractive index
- 1.7500 (estimate)
- storage temp.
- −20°C
- solubility
- 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3 mg/mL
- form
- Solid
- pka
- 9.61±0.60(Predicted)
- color
- Pale Yellow to Pale Beige
- Stability:
- Hygroscopic
- InChIKey
- YDOTUXAWKBPQJW-YBALXUQENA-N
- SMILES
- [C@@]12(O)O[C@@](C(C)C)(NC(=O)[C@H]3CN(C4CC5=CNC6=CC=CC(=C56)C4=C3)C)C(=O)N1[C@@H](CC(C)C)C(=O)N1CCCC21 |&1:0,3,10,30,r|
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
H361Suspected of damaging fertility or the unborn child
H362May cause harm to breast-fed children
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P263Avoid contact during pregnancy/while nursing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E597500
- Product name
- α-Ergocryptine
- Packaging
- 5mg
- Price
- $5775
- Updated
- 2021/12/16
- Product number
- BRS0000412
- Product name
- ALPHA-ERGOCRYPTINE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $11838.75
- Updated
- 2021/12/16
- Product number
- BRS0000412
- Product name
- ALPHA-ERGOCRYPTINE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $2021.25
- Updated
- 2021/12/16
α-Ergocryptine Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Solid
Uses
α-Ergocryptine is an ergopeptine and one of the ergot alkaloids. An impurity of 2-Bromo α-Ergocryptine Mesylate (B682600).
Uses
An impurity of 2-Bromo α-Ergocriptine Mesylate (B682600).
Definition
ChEBI: Ergotaman bearing hydroxy, isopropyl, and 2-methylpropyl groups at the 12', 2' and 5' positions, respectively, and oxo groups at positions 3', 6', and 18. It is a natural ergot alkaloid. Ergocryptine discussed in the literature prior to 1967, when b ta-ergocryptine was separated from alpha-ergocryptine, is now referred to as alpha-ergocryptine.
General Description
One of the biologically most important ergot alkaloids is α-ergocryptine. Its semisynthetic derivative, the so-called bromocryptine, is one of the most widely used drugs in this family (e.g., as a prolactin inhibitor or an anti-Parkinsonian)[2].
Toxicology
A study describes the metabolic changes observed in a dietary subacute toxicity experiment with the ergot alkaloid α-ergocryptine in Sprague±Dawley rats. The rats were fed 0, 4, 20, 100 or 500 mg ergocryptine/kg diet for 28±32 days (equal to 0, 0.36, 1.7, 8.9 and 60 mg ergocryptine/kg body weight/day for females and 0, 0.34, 1.4, 6.6 and 44 mg ergocryptine/kg body weight/day for males). Total cholesterol and high-density lipoprotein (HDL)-cholesterol was decreased dose-dependently in females, but the ratio HDL-cholesterol/total cholesterol was only decreased at 20 mg/kg body weight. Triglycerides and glucose concentrations were decreased in the highest dose groups of both sexes. Serum urea concentrations were increased in the 20, 100 and 500 mg/kg dose groups. Insulin, glucagon and liver glycogen were increased in the highest dose group at the end of the study when the animals were allowed to eat prior to blood sampling and necropsy. Prolactin, T4 and FT4 were decreased in the 20, 100 and 500 mg/kg dose groups of both sexes. Follicle-stimulating hormone (FSH) was decreased in the 20, 100 and 500 mg/kg female dose groups and luteinizing hormone (LH) was increased in the 20, 100 and 500 mg/kg male dose groups[1].
Purification Methods
It crystallises with solvent of crystallisation, from acetone, *benzene or methanol. [Stadler et al. Helv Chim Acta 52 1549 1969, Beilstein 25 III/IV 964, 27 II 860.]
References
[1] G.B Janssen . “Subacute toxicity of α-ergocryptine in Sprague–Dawley rats. 1: general toxicological effects.” Food and Chemical Toxicology 38 8 (2000): Pages 679-688.
[2] I. Moldvai. “Enantioefficient Synthesis of α-Ergocryptine: First Direct Synthesis of (+)-Lysergic Acid (I).” ChemInform 8 1 (2005).
α-Ergocryptine Preparation Products And Raw materials
Raw materials
Preparation Products
α-Ergocryptine Suppliers
- Tel
- 0755 23009027 13602565027
- zhangkun@apinopharma.com
- Country
- China
- ProdList
- 88
- Advantage
- 58
- Tel
- 18627753421 18627756402
- Fax
- QQ：3001051413
- 3001009495@qq.com
- Country
- China
- ProdList
- 19063
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- +1 (866) 930-6790
- Fax
- +1 (866) 333-9607
- info@adooq.com
- Country
- United States
- ProdList
- 2782
- Advantage
- 58
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18070
- Advantage
- 56
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7787
- Advantage
- 56
- Tel
- 021-64609169 18901607656
- Fax
- 021-64609160
- greensnown@163.com
- Country
- China
- ProdList
- 9906
- Advantage
- 50
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2990
- Advantage
- 60
- Tel
- Fax
- -
- xg01_gj@163.com
- Country
- China
- ProdList
- 9484
- Advantage
- 50
View Lastest Price from α-Ergocryptine manufacturers
- Product
- Bromocriptine EP Impurity B 511-09-1
- Price
- US $0.00-0.00/mg
- Min. Order
- 5mg
- Purity
- 95%+
- Supply Ability
- 1000mg
- Release date
- 2025-01-24
- Product
- Bromocriptine Impurity 511-09-1
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98
- Supply Ability
- 10000000
- Release date
- 2024-12-10