α-Ergocryptine

ChemicalBook > CAS DataBase List > α-Ergocryptine

Product Name: α-Ergocryptine
CAS No.: 511-09-1
Chemical Name: α-Ergocryptine
Synonyms: ergocryptine;ergokryptine;Ergocrypyine;Ergocriptine;A-ergocryptine;α-Ergocryptine;alpha-ergokryptine;9,10-Dihydro-βALPHA-ERGOCRYPTINE;ERGOCRYPTINE95%,98%
CBNumber: CB8205993
Molecular Formula: C32H41N5O5
Formula Weight: 575.7
MOL File: 511-09-1.mol

Less

α-Ergocryptine Property

Melting point:: 152-154°C
alpha: D20 -120° (pyridine); -198° (chloroform)
Boiling point:: 636.59°C (rough estimate)
Density: 1.1762 (rough estimate)
refractive index: 1.7500 (estimate)
storage temp.: −20°C
solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3 mg/mL
form: Solid
pka: 9.61±0.60(Predicted)
color: Pale Yellow to Pale Beige
Stability:: Hygroscopic
InChIKey: YDOTUXAWKBPQJW-YBALXUQENA-N
SMILES: [C@@]12(O)O[C@@](C(C)C)(NC(=O)[C@H]3CN(C4CC5=CNC6=CC=CC(=C56)C4=C3)C)C(=O)N1[C@@H](CC(C)C)C(=O)N1CCCC21 |&1:0,3,10,30,r|

Less

Safety

Hazard Codes: Xn
Risk Statements: 62
Safety Statements: 36/37
RIDADR: UN 1544 6.1/PG 3
WGK Germany: 3
RTECS: KE1400000
HazardClass: 6.1(b)
PackingGroup: III

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

H361Suspected of damaging fertility or the unborn child

H362May cause harm to breast-fed children

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

TRC

Product number: E597500
Product name: α-Ergocryptine
Packaging: 5mg
Price: $5775
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BRS0000412
Product name: ALPHA-ERGOCRYPTINE
Purity: 95.00%
Packaging: 10MG
Price: $11838.75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BRS0000412
Product name: ALPHA-ERGOCRYPTINE
Purity: 95.00%
Packaging: 1MG
Price: $2021.25
Updated: 2021/12/16

Less

α-Ergocryptine Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

α-Ergocryptine is an ergopeptine and one of the ergot alkaloids. An impurity of 2-Bromo α-Ergocryptine Mesylate (B682600).

Uses

An impurity of 2-Bromo α-Ergocriptine Mesylate (B682600).

Definition

ChEBI: Ergotaman bearing hydroxy, isopropyl, and 2-methylpropyl groups at the 12', 2' and 5' positions, respectively, and oxo groups at positions 3', 6', and 18. It is a natural ergot alkaloid. Ergocryptine discussed in the literature prior to 1967, when b ta-ergocryptine was separated from alpha-ergocryptine, is now referred to as alpha-ergocryptine.

General Description

One of the biologically most important ergot alkaloids is α-ergocryptine. Its semisynthetic derivative, the so-called bromocryptine, is one of the most widely used drugs in this family (e.g., as a prolactin inhibitor or an anti-Parkinsonian)[2].

Toxicology

A study describes the metabolic changes observed in a dietary subacute toxicity experiment with the ergot alkaloid α-ergocryptine in Sprague±Dawley rats. The rats were fed 0, 4, 20, 100 or 500 mg ergocryptine/kg diet for 28±32 days (equal to 0, 0.36, 1.7, 8.9 and 60 mg ergocryptine/kg body weight/day for females and 0, 0.34, 1.4, 6.6 and 44 mg ergocryptine/kg body weight/day for males). Total cholesterol and high-density lipoprotein (HDL)-cholesterol was decreased dose-dependently in females, but the ratio HDL-cholesterol/total cholesterol was only decreased at 20 mg/kg body weight. Triglycerides and glucose concentrations were decreased in the highest dose groups of both sexes. Serum urea concentrations were increased in the 20, 100 and 500 mg/kg dose groups. Insulin, glucagon and liver glycogen were increased in the highest dose group at the end of the study when the animals were allowed to eat prior to blood sampling and necropsy. Prolactin, T4 and FT4 were decreased in the 20, 100 and 500 mg/kg dose groups of both sexes. Follicle-stimulating hormone (FSH) was decreased in the 20, 100 and 500 mg/kg female dose groups and luteinizing hormone (LH) was increased in the 20, 100 and 500 mg/kg male dose groups[1].

Purification Methods

It crystallises with solvent of crystallisation, from acetone, *benzene or methanol. [Stadler et al. Helv Chim Acta 52 1549 1969, Beilstein 25 III/IV 964, 27 II 860.]

References

[1] G.B Janssen . “Subacute toxicity of α-ergocryptine in Sprague–Dawley rats. 1: general toxicological effects.” Food and Chemical Toxicology 38 8 (2000): Pages 679-688.
[2] I. Moldvai. “Enantioefficient Synthesis of α-Ergocryptine: First Direct Synthesis of (+)-Lysergic Acid (I).” ChemInform 8 1 (2005).

α-Ergocryptine Preparation Products And Raw materials

Raw materials

Preparation Products

Less

α-Ergocryptine Suppliers

Canada 1 China 58 Germany 1 India 4 Switzerland 1 United Kingdom 1 United States 6 Global 72

Apino Pharma Co., Ltd.

Tel: 0755 23009027 13602565027
Email: zhangkun@apinopharma.com
Country: China
ProdList: 88
Advantage: 58

Hubei Moco Chemical Co., Ltd.

Tel: 18627753421 18627756402
Fax: QQ：3001051413
Email: 3001009495@qq.com
Country: China
ProdList: 19063
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18080
Advantage: 56

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7787
Advantage: 56

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9484
Advantage: 50

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-28967200 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9578
Advantage: 60

Hunan chemfish Scientific co.,ltd

Tel: +8618229978283 18229978283
Email: sales@chemfish.com
Country: China
ProdList: 4888
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57423
Advantage: 58

Hangzhou Synstar pharmaceutical Technology CO.,Ltd

Tel: 0571-85361029
Fax: 0571-85361029
Email: synstar518@163.com
Country: China
ProdList: 1990
Advantage: 58

TOSUN PHARM

Tel: 020-61855200 13326451905
Email: 260366801@qq.com
Country: China
ProdList: 7823
Advantage: 58

Zhuoer Chemical Co., Ltd

Tel: 02120970332; +8613524231522
Fax: +86-21-58816016
Email: sales@zhuoerchem.com
Country: China
ProdList: 2904
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 22787
Advantage: 58

HUNAN CHEMFISH SCIENTIFIC CO.,LTD

Tel: +86-0731-85567275 18932438858
Fax: QQ:3554193828
Email: sales05@chemfish.com
Country: China
ProdList: 8332
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

Neostar United (Changzhou) Industrial Co., Ltd.

Tel: +86-0519-85551759 +8613506123987
Fax: +0086-519-85557389
Email: marketing1@neostarunited.com
Country: China
ProdList: 8840
Advantage: 58

Meng Cheng Technology (Shanghai) Co., LTD

Tel: 400-820-6829
Email: sales@mitachieve.com
Country: China
ProdList: 8860
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Zhuhai Anzhe Biotechnology Co,Ltd.

Tel: 13169972583
Email: 513211116@qq.com
Country: China
ProdList: 3006
Advantage: 58

Molcoo Chemicals Inc.

Tel: 18576690171 17386083646
Email: 3001006472@qq.com
Country: China
ProdList: 11837
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81960175-877 18933936954
Email: tianwen.zhan@cato-chem.com
Country: China
ProdList: 7734
Advantage: 58

Cdreamlab (Hubei) Technology Co., LTD

Tel: 0717-6300888 18062399888
Email: service@cdreamlab.com
Country: China
ProdList: 299
Advantage: 58

Shanghai Tachizaki Biomedical Research Center

Tel: 18014399201
Email: sales@chemlab-tachizaki.com
Country: China
ProdList: 2619
Advantage: 58

Wuhan Feiyue Biotechnology Co., LTD

Tel: 027-87002654 18062720658
Email: andydeng@feiyuebio.com
Country: China
ProdList: 805
Advantage: 58

Shanghai Zerui Biotechnology Co., Ltd.

Tel: 021-54580889 18321124657
Fax: 021-54580889
Email: 731997554@qq.com
Country: China
ProdList: 10608
Advantage: 58

Hubei De'ao Chemical Research Pharmaceutical Technology Co., Ltd

Tel: 18502726233; 18502726233
Email: 3641133981@qq.com
Country: China
ProdList: 9713
Advantage: 58

Henan Vcommend Consultrading Co., Ltd.

Tel: 13393721940; 13393721940
Email: sales@vcommend.com
Country: China
ProdList: 10005
Advantage: 58

Cdreamlab (Hubei) Technology Co., LTD

Tel: 18062399888
Email: service@cdreamlab.com
Country: China
ProdList: 124
Advantage: 58

ShenZhen H&D Pharmaceutical Technology Co., LTD

Tel: 2851922763
Email: zhangweiyue@hdimpurity.com
Country: China
ProdList: 7879
Advantage: 58

Cato Research Chemicals Inc.

Tel: 13342851930
Email: 3008394369@qq.com
Country: China
ProdList: 15726
Advantage: 58

Tel: 4008-099-669
Email: 23419001name@qq.com
Country: CHINA
ProdList: 73043
Advantage: 58

Hubei Ruinuo Pharmaceutical Technology Co., Ltd

Tel: 13165688766
Fax: 0714-5316360
Email: 3008058375@qq.com
Country: China
ProdList: 3001
Advantage: 58

Henan Tianfu Chemical Co.,Ltd.

Tel: +86-0371-55170693 +86-19937530512
Fax: 0371-55170693
Email: info@tianfuchem.com
Country: China
ProdList: 21634
Advantage: 55

Guangzhou Tosun Pharmaceutical Ltd

Tel: +86-020-61855200-902 +8618124244216
Email: info@upharm.cn
Country: China
ProdList: 890
Advantage: 58

Guangzhou CATO Research Chemicals Inc.

Tel: +86-020-81960175-617 +8615602392859
Email: Intermediate@cato-chem.com
Country: China
ProdList: 5763
Advantage: 58

XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.

Tel: +8618950047208
Email: ellena@amitychem.com
Country: China
ProdList: 43416
Advantage: 58

Moxin Chemicals

Tel: +8617320513646
Email: mike@molcoo.com
Country: China
ProdList: 9563
Advantage: 58

Hubei Lidu New Material Technology Co., Ltd

Tel: +undefined+86-19307248857
Email: liduxcl@163.com
Country: China
ProdList: 988
Advantage: 58

Dorne Chemical Technology co. LTD

Tel: +86-86-13583358881 +8618560316533
Email: Ethan@dornechem.com
Country: China
ProdList: 3097
Advantage: 58

ShenZhen H&D Pharmaceutical Technology Co., LTD

Tel: +8618627948422
Email: sale@hdimpurity.com
Country: China
ProdList: 3394
Advantage: 58

Shijiazhuang Jianxin Biotechnology Co., LTD

Tel: +undefined-86-1906231316-9 +undefined86-19062313169
Email: liyingjian1997@gmail.com
Country: China
ProdList: 712
Advantage: 58

LEAPCHEM CO., LTD.

Tel: +86-852-30606658
Email: market18@leapchem.com
Country: China
ProdList: 43340
Advantage: 58

China National Standard Pharmaceutical Corporation Limited

Tel: +8615391658522
Email: overseasales@yongstandards.com
Country: China
ProdList: 11922
Advantage: 58

GIHI CHEMICALS CO.,LIMITED

Tel: +8618058761490
Email: info@gihichemicals.com
Country: China
ProdList: 49977
Advantage: 58

PT CHEM GROUP LIMITED

Tel: +86-85511178; +86-85511178;
Email: peter68@ptchemgroup.com
Country: China
ProdList: 35425
Advantage: 58

Gihi Chemicals Co., Limited

Tel: +86-0571-86217390 +8618058761490
Email: info@gihichem.com
Country: China
ProdList: 998
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Less

View Lastest Price from α-Ergocryptine manufacturers

Moxin Chemicals

Product: Bromocriptine Impurity 511-09-1
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98
Supply Ability: 10000000
Release date: 2024-12-10

Guangzhou Tosun Pharmaceutical Ltd

Product: Bromocriptine EP Impurity B 511-09-1
Price: US $0.00-0.00/mg
Min. Order: 5mg
Purity: 95%+
Supply Ability: 1000mg
Release date: 2025-01-24

511-09-1, α-ErgocryptineRelated Search:

Ergotaman-3',6',18-trione, 2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-, (2'β,5'α,8α)- (9CI) BroMocriptine IMpurity G BroMocriptine-13C-d3 BroMocriptine IMpurity F Ergoline-8-carboxylic acid, 2-bromo-9,10-didehydro-6-methyl-, (8β)- Ergocryptine, 2-bromo- (8CI),2-bromo-alpha-ergocryptin (8S)-2-BroMo α-Ergocryptine Bromocriptine mesylate BroMocriptine IMpurity E beta-ergocryptine Bromocriptine Impurity 2 Bromocriptine Impurity A (Mixture of Diastereomers) DIHYDROERGOCRISTINE MESYLATE ERGTOXIN ALPHA-ERGOCRYPTINE Mergocriptine 1-Bromo-α-ergocryptine methane Sulfonate ergocryptine methanesulfonate

12’-hydroxy-2’-(1-methylethyl)-5’-alpha-(2-methylpropyl)ergotaman-3’,6’,18-t

9,10-Dihydro-&beta

alpha-ergokryptine

ergocryptine

ALPHA-ERGOCRYPTINE

A-ergocryptine

12'-hydroxy-5'alpha-isobutyl-2'-isopropylergotaman-3',6',18-trione

ERGOCRYPTINE95%,98%

ergokryptine

Bromocriptine EP Impurity B

12μ-Hydroxy-2μ-(1-methylethyl)-5μ-α-(2-methylpropyl)ergotaman-3μ,6μ,18-trione

12'-Hydroxy-2'-isopropyl-5'α-isobutylergotaman-3',6',18-trione

A-ERGOCRYPTINE ERGOT ALKALOID

Ergocryptine Ergokryptine

ErgotaMan-3',6',18-trione,12'-hydroxy-2'-(1-Methylethyl)-5'-(2-Methylpropyl)-, (5'a)-

(R)-9,10-Dihydro-&beta

Ergotaman-3',6',18-trione, 12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-, (5'α)-

Bromocriptine Impurity 2（Bromocriptine Mesylate EP Impurity B)

α-Ergocryptine

Ergocrypyine

ALPHA-ERGOCRYPTINE USP/EP/BP

Bromocriptine mesilate EP Impurity B

(6aR,9R)-N-[(2R,5S,10aS,10bS)-10b-hydroxy-2-(1-methylethyl)-5-(2-methylpropyl)-3,6-dioxooctahydro-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl]-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (α-ergocryptine),

(6aR,9R)-N-((2R,5S,10aS,10bS)-10b-hydroxy-5-isobutyl-2-isopropyl-3,6-dioxooctahydro-2H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide

Ergocriptine

Bromocryptine EP Impurity B (α-Ergocryptine)

Cilnidipine Impurity 16

12'-hydroxy-5'α-isobutyl-2'-isopropylergotaman-3',6',18-trione

511-09-1

3086-91-8

205448-66-5

C32H41N5O5

Aromatics

Heterocycles

Impurities

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals