2-Piperazinone
- Product Name
- 2-Piperazinone
- CAS No.
- 5625-67-2
- Chemical Name
- 2-Piperazinone
- Synonyms
- PIPERAZIN-2-ONE;2-OXOPIPERAZINE;PIPERAZINE-2-ONE;PIPERAZINONE;NSC 27441;AKOS BBB/413;PIPERBORNENE;2-piperadone;2-piperazone;2-Piperzinone
- CBNumber
- CB3487176
- Molecular Formula
- C4H8N2O
- Formula Weight
- 100.12
- MOL File
- 5625-67-2.mol
2-Piperazinone Property
- Melting point:
- 136-140 °C (lit.)
- Boiling point:
- 164°C/5mmHg(lit.)
- Density
- 1.053±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Chloroform
- form
- Crystalline Powder
- pka
- 15.47±0.20(Predicted)
- color
- White to tan
- Sensitive
- Hygroscopic
- Stability:
- Stable, but may be light and moisture sensitive. Incompatible with oxidizing agents.
- InChI
- InChI=1S/C4H8N2O/c7-4-3-5-1-2-6-4/h5H,1-3H2,(H,6,7)
- InChIKey
- IWELDVXSEVIIGI-UHFFFAOYSA-N
- SMILES
- N1CCNCC1=O
- CAS DataBase Reference
- 5625-67-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-43
- Safety Statements
- 26-36/37
- RIDADR
- 1759
- WGK Germany
- 3
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 641065
- Product name
- 2-Oxopiperazine
- Purity
- 97%
- Packaging
- 1g
- Price
- $30.5
- Updated
- 2025/07/31
- Product number
- 641065
- Product name
- 2-Oxopiperazine
- Purity
- 97%
- Packaging
- 5g
- Price
- $105
- Updated
- 2025/07/31
- Product number
- P1867
- Product name
- 2-Piperazinone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $23
- Updated
- 2025/07/31
- Product number
- P1867
- Product name
- 2-Piperazinone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $67
- Updated
- 2025/07/31
- Product number
- P480140
- Product name
- 2-Piperazinone
- Packaging
- 2g
- Price
- $110
- Updated
- 2021/12/16
2-Piperazinone Chemical Properties,Usage,Production
Chemical Properties
solid
Uses
2-Piperazinone (cas# 5625-67-2) is a compound useful in organic synthesis.
Definition
ChEBI: Piperazine-2-one is a carboximidic acid.
Synthesis
105-39-5
107-15-3
5625-67-2
The general procedure for the synthesis of 2-piperazinone from ethyl chloroacetate and ethylenediamine was as follows: ethyl chloroacetate (4.9 g, 40 mmol) was dissolved in 40 mL of anhydrous ethanol and slowly added dropwise to 100 mL of ethylenediamine (24 g, 400 mmol) over 3.5 hours at room temperature. After the dropwise addition, the reaction mixture was allowed to stand for 2 hours. Subsequently, sodium ethoxide (15 mL, 40 mmol, 21% w/w denatured ethanol solution) was added, the precipitated sodium chloride was removed by filtration and the solvent was evaporated. To the resulting red oil 40 mL of DMF was added and stirred at room temperature for 24 h. The mixture was then heated at 60°C to 70°C while N2 gas was passed through to remove volatiles. The resulting yellow solid was separated by silica gel column chromatography, eluting using a solvent mixture (CHCl3:MeOH:NH4OH = 9:1:0.1) to give the crude product (3.3 g, 33 mmol, 82% yield). This yellow solid was used directly in the next step of the reaction without further purification. Pure white crystals were obtained by three times recrystallization from acetone.1H NMR (CDCl3): δ 1.70 (1H, br s), 3.03 (2H, t, J = 5.4 Hz), 3.37 (2H, td, J = 2.3, 5.4 Hz), 3.52 (2H, s), 6.54 (1H, br s).13C NMR (CDCl3): δ 42.31, 43.05, 49.83, 170.00. melting point: 132°C-134°C (uncorrected) [literature value: 136°C (corrected)] (American Chemical Society Journal, 62 (1940) 1202-1204).
References
[1] Patent: US2005/222166, 2005, A1. Location in patent: Page/Page column 13
[2] Tetrahedron Letters, 1994, vol. 35, # 51, p. 9545 - 9548
[3] Patent: WO2006/51851, 2006, A1. Location in patent: Page/Page column 80
[4] Journal of the American Chemical Society, 1940, vol. 62, p. 1202
2-Piperazinone Preparation Products And Raw materials
Raw materials
Preparation Products
2-Piperazinone Suppliers
- Tel
- --
- Fax
- --
- ardan@micro.lt
- Country
- Lithuania
- ProdList
- 206
- Advantage
- 30
View Lastest Price from 2-Piperazinone manufacturers
- Product
- 2-Piperazinone 5625-67-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- 2-Piperazinone 5625-67-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-20
- Product
- 2-Piperazinone 5625-67-2
- Price
- US $10.00-7.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 20ton
- Release date
- 2024-06-06