ChemicalBook > CAS DataBase List > Nimesulide

Nimesulide

Product Name
Nimesulide
CAS No.
51803-78-2
Chemical Name
Nimesulide
Synonyms
Nide;nimed;AULIN;Nidol;R-805;Aufin;Nisuli;MESULID;Lizepat;Nisulid
CBNumber
CB0138084
Molecular Formula
C13H12N2O5S
Formula Weight
308.31
MOL File
51803-78-2.mol
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Nimesulide Property

Melting point:
140-146°C
storage temp. 
2-8°C
solubility 
Practically insoluble in water, freely soluble in acetone, slightly soluble in anhydrous ethanol.
form 
neat
pka
pKa 6.56± 0.03(H2O,t =25,I=0.02)(Approximate)
Water Solubility 
Soluble in water (<50 &#181;g/ml), 1:10 DMSO:PBS (pH 7.2) (<200 &#181;g/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH.
λmax
391nm(H2O)(lit.)
Merck 
14,6548
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
HYWYRSMBCFDLJT-UHFFFAOYSA-N
CAS DataBase Reference
51803-78-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
36-26
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
PB0970000
HazardClass 
6.1
PackingGroup 
III
Toxicity
LD50 orally in rats: 324 mg/kg (Swingle, Moore)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P321Specific treatment (see … on this label).

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N1016
Product name
Nimesulide
Packaging
1g
Price
$23.7
Updated
2018/11/13
Sigma-Aldrich
Product number
N1016
Product name
Nimesulide
Packaging
5g
Price
$84.9
Updated
2018/11/13
TCI Chemical
Product number
N0984
Product name
Nimesulide
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$21
Updated
2018/11/22
TCI Chemical
Product number
N0984
Product name
Nimesulide
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$59
Updated
2018/11/22
Alfa Aesar
Product number
J63699
Product name
Nimesulide
Packaging
5g
Price
$48.7
Updated
2018/11/13
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Nimesulide Chemical Properties,Usage,Production

Description

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It is indicated for the treatment of acute pain, symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults. However, due to the risk of causing hepatotoxicity, it should not be taken long-term. It has also been withdrawn from the markets in many countries. It mechanism of action is through targeting on various key mediators in the inflammatory process such as COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.

Chemical Properties

Yellow Needle-Like Crystals

Originator

Riker (USA)

Uses

Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-alpha production

Uses

Labelled Nimesulide (N477500). Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-α production.

Uses

Antiinflammatory;'Cyclooxygenase 2 inhibitor

Uses

For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.

Uses

Labelled Nimesulide . Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-α production.;Labeled Nimesulide, intended for use as an internal standard for th

Uses

Nimesulide is a selective inhibitor of COX-2. The IC50 values are 70 and 1.27 μM for human recombinant COX-1 and -2 (at 20 μM arachidonic acid), respectively, and 22 and 0.03 μM for ovine COX-1 and -2 (at 100 μM arachidonic acid), respectively.[Cayman Chemical]

brand name

Nimulid.

Biological Activity

Selective, orally active cyclooxygenase-2 (COX-2) inhibitor. Produces potent analgesic, anti-inflammatory and antipyretic activities in vivo . Reported to produce fewer gastrointestinal side effects than standard NSAIDs.牋.

Clinical Use

Nimesulide is a nonsteroidal antiinflammatory/analgesic agent useful in the treatment of rheumatoid arthritis, as well as acute inflammation such as that induced by periodontal surgery or urinary tract infections.

References

https://en.wikipedia.org/wiki/Nimesulide
https://www.drugbank.ca/drugs/DB04743

Nimesulide Preparation Products And Raw materials

Raw materials

Preparation Products

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Nimesulide Suppliers

Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9933
Advantage
58
Hubei Hengluyuan Technology Co., Ltd.
Tel
+86-027-88188016; +86-027-88188096
Fax
+86-027-51835635
Email
hbhlykj@hotmail.com
Country
CHINA
ProdList
892
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2214
Advantage
55
J & K SCIENTIFIC LTD.
Tel
400-666-7788 +86-10-82848833
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
86-21-50328103 * 801、802、803、804 Mobile:18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15881
Advantage
69
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2349
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
9920
Advantage
62
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
sales@chemlin.com.cn
Country
China
ProdList
19977
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32362
Advantage
50

51803-78-2, NimesulideRelated Search:


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  • C13H7D5N2O5S
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  • Cyclooxygenase (COX) Enzymes
  • Cyclooxygenase Inhibitors
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  • Cell Signaling Enzymes
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