ChemicalBook > CAS DataBase List > Nimesulide

Nimesulide

Product Name
Nimesulide
CAS No.
51803-78-2
Chemical Name
Nimesulide
Synonyms
Nimesulide-d5;N-(4-NITRO-2-PHENOXYPHENYL)METHANESULFONAMIDE;Nide;Nidol;nimed;AULIN;R-805;Aufin;Nisuli;MESULID
CBNumber
CB0138084
Molecular Formula
C13H12N2O5S
Formula Weight
308.31
MOL File
51803-78-2.mol
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Nimesulide Property

Melting point:
140-146°C
Boiling point:
442.0±55.0 °C(Predicted)
Density 
1.451±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Practically insoluble in water, freely soluble in acetone, slightly soluble in anhydrous ethanol.
pka
pKa 6.56± 0.03(H2O,t =25,I=0.02)(Approximate)
form 
Solid
color 
Light orange to Yellow to Green
Water Solubility 
Soluble in water (<50 &#181;g/ml), 1:10 DMSO:PBS (pH 7.2) (<200 &#181;g/ml), ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml), chloroform, dichloromethane, acetone (freely soluble), and 1N NaOH.
λmax
391nm(H2O)(lit.)
Merck 
14,6548
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
HYWYRSMBCFDLJT-UHFFFAOYSA-N
CAS DataBase Reference
51803-78-2(CAS DataBase Reference)
EPA Substance Registry System
Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)- (51803-78-2)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
36-26
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
PB0970000
HS Code 
2935.90.9500
HazardClass 
6.1
PackingGroup 
III
Toxicity
LD50 orally in rats: 324 mg/kg (Swingle, Moore)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N1016
Product name
Nimesulide
Packaging
1g
Price
$30.7
Updated
2024/03/01
Sigma-Aldrich
Product number
N1016
Product name
Nimesulide
Packaging
5g
Price
$109
Updated
2024/03/01
TCI Chemical
Product number
N0984
Product name
Nimesulide
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$20
Updated
2024/03/01
TCI Chemical
Product number
N0984
Product name
Nimesulide
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$53
Updated
2024/03/01
Alfa Aesar
Product number
J63699
Product name
Nimesulide
Packaging
5g
Price
$53.65
Updated
2024/03/01
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Nimesulide Chemical Properties,Usage,Production

Description

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) and COX-2 inhibitor (IC50s = 1.27 and 0.03 μM for the human and ovine enzymes, respectively). It is selective for COX-2 over COX-1 (IC50s = 70 and 22 μM for the human and ovine enzymes, respectively). Nimesulide also inhibits sodium-dependent neutral amino acid transporter (B0AT1) with an IC50 value of 23 μM for the rat kidney transporter. It inhibits infection-induced increases in brain prostaglandin E2 (PGE2; ) levels, as well as reduces pyresis (ED50 = 0.3 mg/kg), in yeast-infected rats. Nimesulide (2.9 mg/kg) inhibits formalin-induced hindpaw thermal hyperalgesia in rats.

Description

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It is indicated for the treatment of acute pain, symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults. However, due to the risk of causing hepatotoxicity, it should not be taken long-term. It has also been withdrawn from the markets in many countries. It mechanism of action is through targeting on various key mediators in the inflammatory process such as COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.

Chemical Properties

Yellow Needle-Like Crystals

Originator

Riker (USA)

Uses

Labelled Nimesulide (N477500). Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-α production.

Uses

Antiinflammatory;'Cyclooxygenase 2 inhibitor

Uses

For the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.

Uses

Labelled Nimesulide . Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-α production.;Labeled Nimesulide, intended for use as an internal standard for th

Uses

Nimesulide is a selective inhibitor of COX-2. The IC50 values are 70 and 1.27 μM for human recombinant COX-1 and -2 (at 20 μM arachidonic acid), respectively, and 22 and 0.03 μM for ovine COX-1 and -2 (at 100 μM arachidonic acid), respectively.[Cayman Chemical]

Uses

Antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-alpha production

Definition

ChEBI: Nimesulide is an aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups. It has a role as a cyclooxygenase 2 inhibitor and a non-steroidal anti-inflammatory drug. It is a C-nitro compound, a sulfonamide and an aromatic ether. It is functionally related to a nitrobenzene.

brand name

Nimulid.

General Description

Nimesulide, a nonsteroidal anti-inflammatory drug (NSAID) belongs to the sulfonanilide class.

Biological Activity

Selective, orally active cyclooxygenase-2 (COX-2) inhibitor. Produces potent analgesic, anti-inflammatory and antipyretic activities in vivo . Reported to produce fewer gastrointestinal side effects than standard NSAIDs.

Biochem/physiol Actions

Highly selective cyclooxygenase-2 inhibitor.

Clinical Use

Nimesulide is a nonsteroidal antiinflammatory/analgesic agent useful in the treatment of rheumatoid arthritis, as well as acute inflammation such as that induced by periodontal surgery or urinary tract infections.

References

https://en.wikipedia.org/wiki/Nimesulide
https://www.drugbank.ca/drugs/DB04743

Nimesulide Preparation Products And Raw materials

Raw materials

Organic base Ethanol Diphenyl ether Methanesulfonyl chloride Bromobenzene Dichloromethane Acetic acid

Preparation Products

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Nimesulide Suppliers

Americas 1 Austria 2 Belgium 2 Brazil 2 Canada 5 China 292 China Hong Kong 1 Europe 4 France 2 Germany 6 Greece 1 India 157 Italy 3 Japan 1 Mexico 3 Nepal 1 Nigeria 1 Poland 1 Singapore 1 Slovenia 1 South Africa 1 South Korea 2 Spain 1 Switzerland 5 United Arab Emirates 1 United Kingdom 20 United States 50 Venezuela 1 Global 568
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View Lastest Price from Nimesulide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Nimesulide 51803-78-2
Price
US $0.00/Kg/Drum
Min. Order
25KG
Purity
98%
Supply Ability
1000kg
Release date
2021-12-13
Hebei Weibang Biotechnology Co., Ltd
Product
Nimesulide 51803-78-2
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-20
Hangzhou Hyper Chemicals Limited
Product
Nimesulide 51803-78-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
USP, BP
Supply Ability
5,000KG
Release date
2024-06-13

51803-78-2, NimesulideRelated Search:

Ethanesulfonamide Methyltrimethoxysilane Methanesulfonamide Dimethyldimethoxysilane N-Methyl methanesulfonamide 1-Phenyl-2-nitropropene 2-Methylbenzene-1-sulfonamide Methyltriethoxysilane Dimethyl sulfone Chlorodimethylphenylsilane 4-Methoxyphenylacetone Diphenyldimethoxysilane nitrotoluene NITROGEN DIOXIDE 2-Methoxy-4-nitroaniline 3-PHENOXYANILINE Cetirizine dihydrochloride N-(2-METHOXY-4-NITRO-PHENYL)-METHANESULFONAMIDE

  • nimed
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  • 4-nitro-2-phenoxy-methanesulfonanilide
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  • C13H7D5N2O5S
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  • BioChemical
  • Application Index