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2-Methoxy-4-nitroaniline

Product Name
2-Methoxy-4-nitroaniline
CAS No.
97-52-9
Chemical Name
2-Methoxy-4-nitroaniline
Synonyms
FAST RED B BASE;FAST RED B;RED B BASE;2-AMINO-5-NITROANISOLE;RED B ASE;METHOXY-4-NITROANILINE;4-NITRO-ORTHO-ANISIDINE;AZOIC DIAZO COMPONENT 5;4-NITRO-2-METHOXYANILINE;2-Methoxy-4-nitrobenzenamine
CBNumber
CB1693973
Molecular Formula
C7H8N2O3
Formula Weight
168.15
MOL File
97-52-9.mol
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2-Methoxy-4-nitroaniline Property

Melting point:
140-142 °C(lit.)
Boiling point:
337.07°C (rough estimate)
Density 
1,211 g/cm3
refractive index 
1.6010 (estimate)
storage temp. 
Store below +30°C.
solubility 
0.2g/l
form 
Crystalline Powder
pka
1.02±0.10(Predicted)
color 
Yellow to orange
PH
6.2 (0.2g/l, H2O, 20℃)
Water Solubility 
slightly soluble
BRN 
879619
InChIKey
GVBHRNIWBGTNQA-UHFFFAOYSA-N
CAS DataBase Reference
97-52-9(CAS DataBase Reference)
NIST Chemistry Reference
Benzenamine, 2-methoxy-4-nitro-(97-52-9)
EPA Substance Registry System
2-Methoxy-4-nitroaniline (97-52-9)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38-20/21/22
Safety Statements 
26-37/39-36/37
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
2
RTECS 
BZ7170000
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29222900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H351Suspected of causing cancer

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
112631
Product name
2-Methoxy-4-nitroaniline
Purity
98%
Packaging
100g
Price
$60.2
Updated
2024/03/01
TCI Chemical
Product number
M0118
Product name
2-Methoxy-4-nitroaniline
Purity
>99.0%(GC)
Packaging
25g
Price
$18
Updated
2024/03/01
TCI Chemical
Product number
M0118
Product name
2-Methoxy-4-nitroaniline
Purity
>99.0%(GC)
Packaging
500g
Price
$193
Updated
2024/03/01
Alfa Aesar
Product number
B24220
Product name
2-Methoxy-4-nitroaniline, 99%
Packaging
25g
Price
$18.65
Updated
2024/03/01
Alfa Aesar
Product number
B24220
Product name
2-Methoxy-4-nitroaniline, 99%
Packaging
100g
Price
$32.65
Updated
2024/03/01
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2-Methoxy-4-nitroaniline Chemical Properties,Usage,Production

Chemical Properties

2-Methoxy-4-nitroaniline is a yellow to orange crystalline powder. 2-Methoxy-4-nitroaniline (MONA) is a potential nonlinear optical (NLO) material, the N12–O19 bond length of MONA molecule is essentially controlled by the p-character of these hybrid orbitals and also by the nature of the N12–O19 bond. The molecular geometry of the compound is almost planar with the substituents[1].

Uses

2-Methoxy-4-nitroaniline is an important intermediate for preparing organic pigments and color bases of ice dyeing dyestuff. As a benzene dye intermediate, It is generally employed to prepare not only fast pigments but also as a printing and dyeing developer for cotton fabrics. In particular, 2-methoxy-4-nitroaniline is also important in production of some antineoplastic drugs[2-3].

Uses

2-Methoxy-4-nitroaniline is used as a photometric reagent for the determination of ethinylestradiol (ETE), a semi-synthetic estrogen that is widely used in oral contraceptives.

General Description

2-Methoxy-4-nitroaniline is an important inducer of CYP1A2 owing to its small molecular size.

Flammability and Explosibility

Non flammable

Biochem/physiol Actions

The metabolism of 2-methoxy-4-nitroaniline (MNA) occurs via the hydroxylation of the phenyl ring to form 6-hydroxy MNA in Harlan Sprague Dawley rats and B6C3F(1)/N mice.

Solubility in organics

The change trend of the solubility magnitude in different monosolvents from high to low was as follows: N-methylpyrrolidone (NMP) > dimethyl sulfoxide (DMSO) > 1,4-dioxane > ethyl acetate > acetonitrile > ethanol > methanol > n-propanol > isopropanol >  ethylene glycol (EG) > n-butanol > water[2].

References

[1] Bao Y, et al. 2-Methoxy-4-nitroaniline Solubility in Several Monosolvents: Measurement, Correlation, and Solvent Effect Analysis. Journal of Chemical & Engineering Data, 2020; 65: 757–765.
[2] Degawa M, et al.2-Methoxy-4-nitroaniline is a selective inducer of cytochrome P450IA2 (CYP1A2) in rat liver. Cancer Letters, 1995; 96: 95-98.
[3] Ravikumar C, et al. Electronic absorption and vibrational spectra and nonlinear optical properties of 4-methoxy-2-nitroaniline. Physical Chemistry Chemical Physics, 2010; 12: 9452-9460.

2-Methoxy-4-nitroaniline Preparation Products And Raw materials

Raw materials

o-Anisidine dilute sulphuric acid P-toluenesulfonyl chloride Nitrification Tosyl chloride PARA TOLUENE Nitric acid Acetic acid

Preparation Products

4-Fluoro-3-methoxyaniline C.I.Pigment Yellow 98 5-CHLORO-2-NITROANISOLE 8-METHOXYQUINOLIN-6-AMINE
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2-Methoxy-4-nitroaniline Suppliers

Americas 1 Belgium 1 China 206 Czech Republic 1 Europe 2 Germany 3 India 36 Indonesia 1 Japan 4 Slovakia 1 Switzerland 1 The Netherlands 1 Ukraine 2 United Kingdom 10 United States 29 Global 299
Xiangshui Henryda Tech Chemical Co., Ltd.
Tel
13771648447
Fax
+86-512-69233657
Email
sales@henryda-chem.com
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China
ProdList
61
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58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
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62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
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56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
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81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
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Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
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61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
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56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
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View Lastest Price from 2-Methoxy-4-nitroaniline manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
2-Methoxy-4-nitroaniline 97-52-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-19
Qingdao RENAS Polymer Material Co., Ltd.
Product
Brilliant Red Developing Base 4B 97-52-9
Price
US $0.00/kg
Min. Order
20kg
Purity
99%
Supply Ability
20 tons
Release date
2024-08-27
Qingdao RENAS Polymer Material Co., Ltd.
Product
Brilliant Red Developing Base 4B 97-52-9
Price
US $0.00/kg
Min. Order
20kg
Purity
99%
Supply Ability
20 tons
Release date
2024-09-29

97-52-9, 2-Methoxy-4-nitroanilineRelated Search:

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