4-Fluoro-3-methoxyaniline

Product Name: 4-Fluoro-3-methoxyaniline
CAS No.: 64465-53-8
Chemical Name: 4-Fluoro-3-methoxyaniline
Synonyms: BUTTPARK 14\01-65;5-Amino-2-fluoroanisole;3-METHOXY-4-FLUOROANILINE;4-FLUORO-3-METHOXYANILINE;4-Fluoro-3-Methoxybenzenamin;4-Fluoro-3-methoxyphenylamine;4-FLUORO-3-METHOXYBENZENAMINE;Benzenamine, 4-fluoro-3-methoxy-;4-Fluoro-3-methoxyaniline AldrichCPR;5-Amino-2-fluoroanisole, 4-Fluoro-m-anisidine
CBNumber: CB1409132
Molecular Formula: C7H8FNO
Formula Weight: 141.14
MOL File: 64465-53-8.mol

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4-Fluoro-3-methoxyaniline Property

Melting point:: 66-68
Boiling point:: 135 °C(Press: 18 Torr)
Density: 1.176±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
form: solid
pka: 4.23±0.10(Predicted)
color: Brown to black
InChI: InChI=1S/C7H8FNO/c1-10-7-4-5(9)2-3-6(7)8/h2-4H,9H2,1H3
InChIKey: XAACOEWSHBIFGJ-UHFFFAOYSA-N
SMILES: C1(N)=CC=C(F)C(OC)=C1
CAS DataBase Reference: 64465-53-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-36/37/38-52-41-37/38-22
Safety Statements: 26-36/37/39-39
HazardClass: IRRITANT
HS Code: 2922290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: F1298
Product name: 4-Fluoro-3-methoxyaniline
Purity: min. 98.0 %
Packaging: 5G
Price: $76
Updated: 2025/07/31

TCI Chemical

Product number: F1298
Product name: 4-Fluoro-3-methoxyaniline
Purity: min. 98.0 %
Packaging: 25G
Price: $301
Updated: 2025/07/31

TRC

Product number: F592245
Product name: 4-Fluoro-3-methoxyaniline
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: F592245
Product name: 4-Fluoro-3-methoxyaniline
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Apolloscientific

Product number: PC9111
Product name: 4-Fluoro-3-methoxyaniline
Packaging: 25g
Price: $74
Updated: 2021/12/16

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4-Fluoro-3-methoxyaniline Chemical Properties,Usage,Production

Synthesis Reference(s)

The Journal of Organic Chemistry, 46, p. 2520, 1981 DOI: 10.1021/jo00325a017

Synthesis

454-16-0

64465-53-8

General procedure for the synthesis of 4-fluoro-3-methoxyaniline from 2-fluoro-5-nitroanisole: 1. Reduction of nitro: The nitro compound 2-fluoro-5-nitroanisole (6.5 g, 0.038 mol) and iron powder (10.6 g, 0.19 mol) were suspended in ethanol (90 ml) and heated to 50 °C. Concentrated hydrochloric acid (120 ml) was added dropwise to the reaction mixture at 0°C. The reaction mixture was stirred at 20°C for 18 hours. 2. Post-treatment: the reaction mixture was filtered through diatomaceous earth and the filter cake was washed repeatedly with ethanol. The filtrate and washings were combined and concentrated under reduced pressure to remove ethanol. The residue was alkalized to pH neutral with solid Na2CO3. 3. Extraction and purification: Extract the alkalized aqueous phase with ethyl acetate and combine the organic phases. The organic phase was washed with water and saturated saline in turn, and then dried with anhydrous Na2SO4. The drier was removed by filtration, and the organic phase was concentrated under reduced pressure to obtain 4-fluoro-3-methoxyaniline (5g, 93% yield). Product characterization: HPLC-MS showed a purity of 97% and a molecular ion peak (M+1) of 142.1.

References

[1] Patent: WO2017/132928, 2017, A1. Location in patent: Paragraph 000101
[2] Patent: WO2010/145989, 2010, A1. Location in patent: Page/Page column 12-13
[3] Patent: US4044049, 1977, A
[4] Patent: US4044049, 1977, A

4-Fluoro-3-methoxyaniline Preparation Products And Raw materials

Raw materials

2-Methoxy-4-nitroaniline Sodium Sodium nitrite Fluoroboric acid Ammonium chloride 3,4-Difluoronitrobenzene Hydrochloric acid Iron

Preparation Products

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4-Fluoro-3-methoxyaniline Suppliers

Canada 1 China 168 Germany 4 India 3 Italy 1 United Kingdom 11 United States 25 Global 213

Hubei Chenghai Chemical Co., Ltd

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J & K SCIENTIFIC LTD.

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INTATRADE GmbH

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Energy Chemical

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Shijiazhuang Sdyano Fine Chemical Co., Ltd.

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Wuhan Chemwish Technology Co., Ltd

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Capot Chemical Co., Ltd

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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

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Jia Xing Isenchem Co.,Ltd

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Accela ChemBio Co.,Ltd.

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View Lastest Price from 4-Fluoro-3-methoxyaniline manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 4-Fluoro-3-Methoxyaniline 64465-53-8
Price: US $99.00-45.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-12-05

Henan Fengda Chemical Co., Ltd

Product: 4-Fluoro-3-methoxyaniline 64465-53-8
Price: US $8.00-0.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-22

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-Fluoro-3-methoxyaniline 64465-53-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

64465-53-8, 4-Fluoro-3-methoxyanilineRelated Search:

4-Methoxyphenylacetone 4-(Trifluoromethoxy)aniline (Trifluoromethoxy)benzene 2,4,5-Trifluoroaniline 4-Fluoroaniline p-Anisidine 2-Fluoroaniline m-Anisidine 3-Ethoxyaniline Anisole p-Anisaldehyde Fluorine 3-METHOXY-2,4,5-TRIFLUOROBENZAMIDE 4-FLUORO-3-(TRIFLUOROMETHOXY)BENZYLAMINE 3,5-DIFLUORO-4-METHOXYANILINE 5-Fluoro-2-methoxyaniline hydrochloride 2,4-DIFLUORO-3-METHOXYANILINE 3-FLUORO-2-METHOXYANILINE

BUTTPARK 14\01-65

4-FLUORO-3-METHOXYANILINE

3-METHOXY-4-FLUOROANILINE

4-Fluoro-3-Methoxybenzenamin

4-FLUORO-3-METHOXYBENZENAMINE

4-Fluoro-3-methoxyphenylamine

2-fluoro-5-aminoanisole(4-fluoro-3-methoxyaniline)

5-Amino-2-fluoroanisole, 4-Fluoro-m-anisidine

5-AMino-2-fluoroanisole[4-Fluoro-3-Methoxyaniline]

4-Fluoro-3-methoxyaniline AldrichCPR

5-Amino-2-fluoroanisole

Benzenamine, 4-fluoro-3-methoxy-

64465-53-8

164465-53-8

Multisubstituted Benzene

Amines and Anilines

Halides

Amines

blocks

FluoroCompounds

Anilines, Aromatic Amines and Nitro Compounds