4-Fluoroaniline
- Product Name
- 4-Fluoroaniline
- CAS No.
- 371-40-4
- Chemical Name
- 4-Fluoroaniline
- Synonyms
- P-FLUOROANILINE;fluoroanilines;4-fluorobenzenamine;1-AMINO-4-FLUOROBENZENE;NSC 579;uoroaniL;AKOS 91149;4-Fluoranilin;4-fluoro-anilin;p-fluoro-anilin
- CBNumber
- CB8143013
- Molecular Formula
- C6H6FN
- Formula Weight
- 111.12
- MOL File
- 371-40-4.mol
4-Fluoroaniline Property
- Melting point:
- -1.9 °C
- Boiling point:
- 187 °C/767 mmHg (lit.)
- Density
- 1.173 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.539(lit.)
- Flash point:
- 165 °F
- storage temp.
- 2-8°C
- solubility
- 33g/l
- pka
- 4.65(at 25℃)
- form
- Oily Liquid
- Specific Gravity
- 1.173
- color
- Clear pale yellow to red-brown
- Water Solubility
- 33 g/L (20 ºC)
- Merck
- 14,4169
- BRN
- 742030
- Stability:
- Stable. Incompatible with acids, oxidizing agents.
- CAS DataBase Reference
- 371-40-4(CAS DataBase Reference)
- NIST Chemistry Reference
- p-Fluoroaniline(371-40-4)
- EPA Substance Registry System
- p-Fluoroaniline (371-40-4)
Safety
- Hazard Codes
- C,T,Xi,Xn
- Risk Statements
- 22-34-36/38-33-23/24/25
- Safety Statements
- 26-36/37/39-45-37/39-28
- RIDADR
- UN 2941 6.1/PG 3
- WGK Germany
- 1
- RTECS
- BY1575000
- Hazard Note
- Toxic/Irritant
- TSCA
- T
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29214210
- Hazardous Substances Data
- 371-40-4(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H314Causes severe skin burns and eye damage
H373May cause damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P314Get medical advice/attention if you feel unwell.
N-Bromosuccinimide Price
- Product number
- F3800
- Product name
- 4-Fluoroaniline
- Purity
- 99%
- Packaging
- 25g
- Price
- $24.1
- Updated
- 2024/03/01
- Product number
- F0033
- Product name
- 4-Fluoroaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 25mL
- Price
- $50
- Updated
- 2024/03/01
- Product number
- F0033
- Product name
- 4-Fluoroaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 500mL
- Price
- $528
- Updated
- 2021/12/16
- Product number
- A15597
- Product name
- 4-Fluoroaniline, 99%
- Packaging
- 25g
- Price
- $24
- Updated
- 2024/03/01
- Product number
- A15597
- Product name
- 4-Fluoroaniline, 99%
- Packaging
- 100g
- Price
- $43.1
- Updated
- 2024/03/01
4-Fluoroaniline Chemical Properties,Usage,Production
Chemical Properties
4-Fluoroaniline is a light yellow to gold-coloured liquid.It is easy to oxidize and turn red in air.
Uses
4-Fluoroaniline is a degradation product of Ezetimibe (E975000). 4-Fluoroaniline is used as an analytical reagent in the enzymic detection of glucose.
Uses
4-Fluoroaniline may be employed as one of the target pollutant during the investigation of biodegradability of fluorinated compounds under aerobic conditions. It may be used for the synthesis of luminescent and cationic monocyclometalated gold(III) monoaryl complexes.
Uses
Intermediate in the manufacture of herbicides and plant growth regulators.
Preparation
The better process in the one-step process is the nitrobenzene method, which is obtained by deoxygenation, hydrogenation and fluorination. With PdCl2-V2O5 as the catalyst and carbon monoxide as the reducing agent, the reaction was carried out at 160°C for 3h, and the yield of 4-fluoroaniline could reach 90%, with another 10% of aniline as a by-product. With PtO2 as the catalyst, BF3-HF as the fluorinating agent and hydrogen as the reducing agent, the reaction was carried out at 42℃ for 12.5h, with 100% conversion and 95% yield.
Definition
ChEBI: 4-fluoroaniline is a primary arylamine that is the derivative of aniline in which the hydrogen at position 4 has been substituted by fluorine. It is used as an intermediate in the manufacture of pharmaceuticals, herbicides and plant growth regulators. It is a primary arylamine and a fluoroaniline.
Synthesis Reference(s)
Journal of the American Chemical Society, 70, p. 654, 1948 DOI: 10.1021/ja01182a065
The Journal of Organic Chemistry, 26, p. 4014, 1961 DOI: 10.1021/jo01068a089
General Description
4-fluoroaniline is a light-colored oily liquid. Mixture of three isomers. Insoluble in water and denser than water. Contact may cause irritation to skin, eyes, and mucous membranes. May be toxic by ingestion. Used to make other chemicals. The barriers to inversion and internal rotation of the NH2 group in 4-fluoroaniline has been investigated by far infrared gas spectra.
Hazard
Toxic material.
Flammability and Explosibility
Not classified
Safety Profile
Poison by ingestion. Mutation data reported. A severe skin and eye irritant. When heated to decomposition it emits very toxic fumes of NOx and F-.
4-Fluoroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Fluoroaniline manufacturers
- Product
- 4-Fluoroaniline 371-40-4
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-22
- Product
- 4-Fluoroaniline 371-40-4
- Price
- US $132.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1-20mt
- Release date
- 2021-06-08
- Product
- 4-Fluoroaniline 371-40-4
- Price
- US $10.00/mL
- Min. Order
- 1mL
- Purity
- 99%
- Supply Ability
- 5000L
- Release date
- 2023-04-12