ChemicalBook > CAS DataBase List > 4-Fluoroaniline

4-Fluoroaniline

Product Name
4-Fluoroaniline
CAS No.
371-40-4
Chemical Name
4-Fluoroaniline
Synonyms
P-FLUOROANILINE;fluoroanilines;4-fluorobenzenamine;1-AMINO-4-FLUOROBENZENE;NSC 579;uoroaniL;AKOS 91149;4-Fluoranilin;4-fluoro-anilin;p-fluoro-anilin
CBNumber
CB8143013
Molecular Formula
C6H6FN
Formula Weight
111.12
MOL File
371-40-4.mol
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4-Fluoroaniline Property

Melting point:
-1.9 °C
Boiling point:
187 °C/767 mmHg (lit.)
Density 
1.173 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.539(lit.)
Flash point:
165 °F
storage temp. 
2-8°C
solubility 
33g/l
pka
4.65(at 25℃)
form 
Oily Liquid
Specific Gravity
1.173
color 
Clear pale yellow to red-brown
Water Solubility 
33 g/L (20 ºC)
Merck 
14,4169
BRN 
742030
Stability:
Stable. Incompatible with acids, oxidizing agents.
CAS DataBase Reference
371-40-4(CAS DataBase Reference)
NIST Chemistry Reference
p-Fluoroaniline(371-40-4)
EPA Substance Registry System
p-Fluoroaniline (371-40-4)
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Safety

Hazard Codes 
C,T,Xi,Xn
Risk Statements 
22-34-36/38-33-23/24/25
Safety Statements 
26-36/37/39-45-37/39-28
RIDADR 
UN 2941 6.1/PG 3
WGK Germany 
1
RTECS 
BY1575000
Hazard Note 
Toxic/Irritant
TSCA 
T
HazardClass 
6.1
PackingGroup 
III
HS Code 
29214210
Hazardous Substances Data
371-40-4(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F3800
Product name
4-Fluoroaniline
Purity
99%
Packaging
25g
Price
$24.1
Updated
2024/03/01
TCI Chemical
Product number
F0033
Product name
4-Fluoroaniline
Purity
>98.0%(GC)(T)
Packaging
25mL
Price
$50
Updated
2024/03/01
TCI Chemical
Product number
F0033
Product name
4-Fluoroaniline
Purity
>98.0%(GC)(T)
Packaging
500mL
Price
$528
Updated
2021/12/16
Alfa Aesar
Product number
A15597
Product name
4-Fluoroaniline, 99%
Packaging
25g
Price
$24
Updated
2024/03/01
Alfa Aesar
Product number
A15597
Product name
4-Fluoroaniline, 99%
Packaging
100g
Price
$43.1
Updated
2024/03/01
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4-Fluoroaniline Chemical Properties,Usage,Production

Chemical Properties

4-Fluoroaniline is a light yellow to gold-coloured liquid.It is easy to oxidize and turn red in air.

Uses

4-Fluoroaniline is a degradation product of Ezetimibe (E975000). 4-Fluoroaniline is used as an analytical reagent in the enzymic detection of glucose.

Uses

4-Fluoroaniline may be employed as one of the target pollutant during the investigation of biodegradability of fluorinated compounds under aerobic conditions. It may be used for the synthesis of luminescent and cationic monocyclometalated gold(III) monoaryl complexes.

Uses

Intermediate in the manufacture of herbicides and plant growth regulators.

Preparation

The better process in the one-step process is the nitrobenzene method, which is obtained by deoxygenation, hydrogenation and fluorination. With PdCl2-V2O5 as the catalyst and carbon monoxide as the reducing agent, the reaction was carried out at 160°C for 3h, and the yield of 4-fluoroaniline could reach 90%, with another 10% of aniline as a by-product. With PtO2 as the catalyst, BF3-HF as the fluorinating agent and hydrogen as the reducing agent, the reaction was carried out at 42℃ for 12.5h, with 100% conversion and 95% yield.

Definition

ChEBI: 4-fluoroaniline is a primary arylamine that is the derivative of aniline in which the hydrogen at position 4 has been substituted by fluorine. It is used as an intermediate in the manufacture of pharmaceuticals, herbicides and plant growth regulators. It is a primary arylamine and a fluoroaniline.

Synthesis Reference(s)

Journal of the American Chemical Society, 70, p. 654, 1948 DOI: 10.1021/ja01182a065
The Journal of Organic Chemistry, 26, p. 4014, 1961 DOI: 10.1021/jo01068a089

General Description

4-fluoroaniline is a light-colored oily liquid. Mixture of three isomers. Insoluble in water and denser than water. Contact may cause irritation to skin, eyes, and mucous membranes. May be toxic by ingestion. Used to make other chemicals. The barriers to inversion and internal rotation of the NH2 group in 4-fluoroaniline has been investigated by far infrared gas spectra.

Hazard

Toxic material.

Flammability and Explosibility

Not classified

Safety Profile

Poison by ingestion. Mutation data reported. A severe skin and eye irritant. When heated to decomposition it emits very toxic fumes of NOx and F-.

4-Fluoroaniline Preparation Products And Raw materials

Raw materials

Phenyl phosphine Fluorine 4-Fluoronitrobenzene 4-Chloronitrobenzene Formic acid Styrene Sulfolane Potassium fluoride N-Phenylhydroxylamine Polyethylene Glycol Benzotrichloride Dimethyl sulfoxide N,N-Dimethylacetamide 15-Crown-5

Preparation Products

6-Fluoro-4-(trifluoromethyl)quinolin-2-amine ,97% 2-Hydroxy-4-(trifluoromethyl)quinoline 1-FLUORO-4-(TRIFLUOROMETHYLTHIO)BENZENE 2-BROMO-6-METHYL-4-NITROANILINE N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline 4-BROMO-6-FLUORO-2-(TRIFLUOROMETHYL)QUINOLINE 4-(Trifluoromethyl)quinoline-2-carbohydrazide ,97% (6-Fluoro-4-(trifluoromethyl)quinolin-2-yl)methanol ,97% Ethyl 6-fluoro-4-(trifluoromethyl)quinoline-2-carboxylate ,97% 4-FLUORO-N-METHYLANILINE 2-Bromo-6-fluoro-4-(trifluoromethyl)quinoline 6-FLUORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE (4-(Trifluoromethyl)quinolin-2-yl)methanol ,97% Sarafloxacin 4-(Trifluoromethyl)quinolin-2-amine 6-Fluoro-4-(trifluoromethyl)quinoline-2-carboxylic acid ,97% 2-BROMO-4-(TRIFLUOROMETHYL)QUINOLINE 4-Fluorophenyl isocyanate 6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone 4-TRIFLUOROMETHYL-QUINOLINE-2-CARBOXYLIC ACID
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View Lastest Price from 4-Fluoroaniline manufacturers

Baoji Guokang Bio-Technology Co., Ltd.
Product
4-Fluoroaniline 371-40-4
Price
US $132.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1-20mt
Release date
2021-06-08
Wuhan Boyuan Import & Export Co., LTD
Product
4-Fluoroaniline 371-40-4
Price
US $10.00/mL
Min. Order
1mL
Purity
99%
Supply Ability
5000L
Release date
2023-04-12
Hebei Weibang Biotechnology Co., Ltd
Product
4-Fluoroaniline 371-40-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-07-16

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