4-Fluoroaniline

ChemicalBook > CAS DataBase List > 4-Fluoroaniline

Product Name: 4-Fluoroaniline
CAS No.: 371-40-4
Chemical Name: 4-Fluoroaniline
Synonyms: P-FLUOROANILINE;fluoroanilines;4-fluorobenzenamine;1-AMINO-4-FLUOROBENZENE;NSC 579;uoroaniL;AKOS 91149;4-Fluoranilin;4-fluoro-anilin;p-fluoro-anilin
CBNumber: CB8143013
Molecular Formula: C6H6FN
Formula Weight: 111.12
MOL File: 371-40-4.mol

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4-Fluoroaniline Property

Melting point:: -1.9 °C
Boiling point:: 187 °C/767 mmHg (lit.)
Density: 1.173 g/mL at 25 °C (lit.)
refractive index: n20/D 1.539(lit.)
Flash point:: 165 °F
storage temp.: 2-8°C
solubility: 33g/l
pka: 4.65(at 25℃)
form: Oily Liquid
Specific Gravity: 1.173
color: Clear pale yellow to red-brown
Water Solubility: 33 g/L (20 ºC)
Merck: 14,4169
BRN: 742030
Stability:: Stable. Incompatible with acids, oxidizing agents.
CAS DataBase Reference: 371-40-4(CAS DataBase Reference)
NIST Chemistry Reference: p-Fluoroaniline(371-40-4)
EPA Substance Registry System: p-Fluoroaniline (371-40-4)

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Safety

Hazard Codes: C,T,Xi,Xn
Risk Statements: 22-34-36/38-33-23/24/25
Safety Statements: 26-36/37/39-45-37/39-28
RIDADR: UN 2941 6.1/PG 3
WGK Germany: 1
RTECS: BY1575000
Hazard Note: Toxic/Irritant
TSCA: T
HazardClass: 6.1
PackingGroup: III
HS Code: 29214210
Hazardous Substances Data: 371-40-4(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F3800
Product name: 4-Fluoroaniline
Purity: 99%
Packaging: 25g
Price: $24.1
Updated: 2024/03/01

TCI Chemical

Product number: F0033
Product name: 4-Fluoroaniline
Purity: >98.0%(GC)(T)
Packaging: 25mL
Price: $50
Updated: 2024/03/01

TCI Chemical

Product number: F0033
Product name: 4-Fluoroaniline
Purity: >98.0%(GC)(T)
Packaging: 500mL
Price: $528
Updated: 2021/12/16

Alfa Aesar

Product number: A15597
Product name: 4-Fluoroaniline, 99%
Packaging: 25g
Price: $24
Updated: 2024/03/01

Alfa Aesar

Product number: A15597
Product name: 4-Fluoroaniline, 99%
Packaging: 100g
Price: $43.1
Updated: 2024/03/01

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4-Fluoroaniline Chemical Properties,Usage,Production

Chemical Properties

4-Fluoroaniline is a light yellow to gold-coloured liquid.It is easy to oxidize and turn red in air.

Uses

4-Fluoroaniline is a degradation product of Ezetimibe (E975000). 4-Fluoroaniline is used as an analytical reagent in the enzymic detection of glucose.

Uses

4-Fluoroaniline may be employed as one of the target pollutant during the investigation of biodegradability of fluorinated compounds under aerobic conditions. It may be used for the synthesis of luminescent and cationic monocyclometalated gold(III) monoaryl complexes.

Uses

Intermediate in the manufacture of herbicides and plant growth regulators.

Preparation

The better process in the one-step process is the nitrobenzene method, which is obtained by deoxygenation, hydrogenation and fluorination. With PdCl2-V2O5 as the catalyst and carbon monoxide as the reducing agent, the reaction was carried out at 160°C for 3h, and the yield of 4-fluoroaniline could reach 90%, with another 10% of aniline as a by-product. With PtO2 as the catalyst, BF3-HF as the fluorinating agent and hydrogen as the reducing agent, the reaction was carried out at 42℃ for 12.5h, with 100% conversion and 95% yield.

Definition

ChEBI: 4-fluoroaniline is a primary arylamine that is the derivative of aniline in which the hydrogen at position 4 has been substituted by fluorine. It is used as an intermediate in the manufacture of pharmaceuticals, herbicides and plant growth regulators. It is a primary arylamine and a fluoroaniline.

Synthesis Reference(s)

Journal of the American Chemical Society, 70, p. 654, 1948 DOI: 10.1021/ja01182a065
The Journal of Organic Chemistry, 26, p. 4014, 1961 DOI: 10.1021/jo01068a089

General Description

4-fluoroaniline is a light-colored oily liquid. Mixture of three isomers. Insoluble in water and denser than water. Contact may cause irritation to skin, eyes, and mucous membranes. May be toxic by ingestion. Used to make other chemicals. The barriers to inversion and internal rotation of the NH2 group in 4-fluoroaniline has been investigated by far infrared gas spectra.

Hazard

Toxic material.

Flammability and Explosibility

Not classified

Safety Profile

Poison by ingestion. Mutation data reported. A severe skin and eye irritant. When heated to decomposition it emits very toxic fumes of NOx and F-.

4-Fluoroaniline Preparation Products And Raw materials

Raw materials

Phenyl phosphine Fluorine 4-Fluoronitrobenzene 4-Chloronitrobenzene Formic acid Styrene Sulfolane Potassium fluoride N-Phenylhydroxylamine Polyethylene Glycol Benzotrichloride Dimethyl sulfoxide N,N-Dimethylacetamide 15-Crown-5

Preparation Products

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View Lastest Price from 4-Fluoroaniline manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: 4-Fluoroaniline 371-40-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-22

Baoji Guokang Bio-Technology Co., Ltd.

Product: 4-Fluoroaniline 371-40-4
Price: US $132.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1-20mt
Release date: 2021-06-08

Wuhan Boyuan Import & Export Co., LTD

Product: 4-Fluoroaniline 371-40-4
Price: US $10.00/mL
Min. Order: 1mL
Purity: 99%
Supply Ability: 5000L
Release date: 2023-04-12

371-40-4, 4-FluoroanilineRelated Search:

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371-40-4

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