N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

Product Name: N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline
CAS No.: 70627-52-0
Chemical Name: N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline
Synonyms: ETMB-02;Ezetimibe Impurity 80;Propanoylchloride,5-ethoxy-;4-Benzyloxybenzylidene-(4-f...;EZETIMIBE 163222-33-1 INTERMEDIATES;1H-Indene-1,3(2H)-dione,5,11-dichloro-;4-(4-Benzyloxybenzylidene)Fluoroaniline;4-BENZYLOXYBENZYLIDENE-(4-FLUORO)ANILINE;4'-(Benzyloxy)benzylidene-4-fluoroaniline;4, 4-Benzyloxybenzylidene P- Fluoroaniline
CBNumber: CB2363060
Molecular Formula: C20H16FNO
Formula Weight: 305.35
MOL File: 70627-52-0.mol

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N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Property

Melting point:: 136-138 ºC
Boiling point:: 455.2±35.0 °C(Predicted)
Density: 1.07
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Acetonitrile (Slightly), Chlorofrom (Slightly), Methanol (Slightly, Sonicated)
form: Solid
pka: 3.71±0.50(Predicted)
color: Very Dark Orange
InChI: InChI=1S/C20H16FNO/c21-18-8-10-19(11-9-18)22-14-16-6-12-20(13-7-16)23-15-17-4-2-1-3-5-17/h1-14H,15H2
InChIKey: IWNBEFDVKWCBFY-UHFFFAOYSA-N
SMILES: C1(N=CC2=CC=C(OCC3=CC=CC=C3)C=C2)=CC=C(F)C=C1
CAS DataBase Reference: 70627-52-0

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Safety

HS Code: 2925.29.9000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4301
Product name: 4'-(Benzyloxy)benzylidene-4-fluoroaniline
Purity: >98.0%(GC)
Packaging: 5g
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: B4301
Product name: 4'-(Benzyloxy)benzylidene-4-fluoroaniline
Purity: >98.0%(GC)
Packaging: 25g
Price: $192
Updated: 2025/07/31

TRC

Product number: B286525
Product name: 4-Benzyloxybenzylidene4-Fluoroaniline
Packaging: 100mg
Price: $150
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0012856
Product name: 4-BENZYLOXYBENZYLIDENE-(4-FLUORO)ANILINE
Purity: 95.00%
Packaging: 1G
Price: $1380.23
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 43706
Product name: 4-Benzyloxybenzylidene4-Fluoroaniline
Packaging: 1g
Price: $2200
Updated: 2021/12/16

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N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Chemical Properties,Usage,Production

Uses

4-Benzyloxybenzylidene 4-Fluoroaniline is an intermediate in the synthesis of Linezolid (L466500).

Synthesis

4397-53-9

371-40-4

70627-52-0

General procedure for the synthesis of 4-benzylbenzylidene-(4-fluoro)aniline from 4-benzyloxybenzaldehyde and 4-fluorobenzenamine: 4-fluorobenzylidene-(4-fluoro)aniline (100 g, 1.1 eq.) was mixed with isopropanol (1730 ml, 10 V) and heated under mechanical stirring up to 40 °C, whereby a large amount of light yellow crystalline solid was gradually precipitated. Stirring was continued and the reaction was monitored until completion. The heating was stopped and the reaction was cooled naturally to room temperature with stirring. Extraction and filtration operations were carried out, and the filter cake was washed with cold isopropanol and dried to give the light yellow crystalline product SM 2 with a mass of 238 g, 95% yield and 99% purity.

References

[1] Patent: JP2016/147843, 2016, A. Location in patent: Paragraph 0016
[2] Patent: CN107793339, 2018, A. Location in patent: Paragraph 0021; 0023; 0031; 0038
[3] Pharmacy and Pharmacology Communications, 2000, vol. 6, # 1, p. 25 - 29
[4] Journal of Organic Chemistry, 2018,

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Preparation Products And Raw materials

Raw materials

Ethanol N,N-Dimethylformamide Potassium iodide Sodium sulfate Potassium carbonate PETROLEUM ETHER 4-Hydroxybenzaldehyde Benzyl bromide Ethyl acetate 4-Fluoroaniline

Preparation Products

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N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Suppliers

Americas 1 Canada 1 China 164 Europe 2 Germany 1 India 25 Japan 1 Russia 1 United Kingdom 2 United States 16 Global 214

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
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INTATRADE GmbH

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Email: sales@intatrade.de
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TCI (Shanghai) Development Co., Ltd.

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Email: Sales-CN@TCIchemicals.com
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Capot Chemical Co., Ltd

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Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
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Email: info@yuhaochemical.com
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View Lastest Price from N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-BENZYLOXYBENZYLIDENE-(4-FLUORO)ANILINE 70627-52-0
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-24

Henan Aochuang Chemical Co.,Ltd.

Product: N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline 70627-52-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Shanghai CRM New Material Technology Co., LTD

Product: N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline 70627-52-0
Price: US $10.00-15.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 2546245
Release date: 2022-11-10

70627-52-0, N-(4-(Benzyloxy)benzylidene)-4-fluoroanilineRelated Search:

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4-BENZYLOXYBENZYLIDENE-(4-FLUORO)ANILINE

4-(4-Benzyloxybenzylidene)Fluoroaniline

N-(4-(benzyloxy)benzylidene)-4-fluorobenzenamine

4-Fluoro-N-[[4-(phenylmethoxy)phenyl]methylene]benzenamine

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

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4-Benzyloxybenzylidene-(4-f...

BenzenaMine,4-fluoro-N-[[4-(phenylMethoxy)phenyl]Methylene]-

ETMB-02

N-(4-fluorophenyl)-1-(4-phenylmethoxyphenyl)methanimine

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline70627-52-0

Ezetimibe Impurity 80

N-fluoro-4-[(4-phenylmethoxyphenyl)methylidene]-1-cyclohexa-1,5-dienamine

4'-(Benzyloxy)benzylidene-4-fluoroaniline &gt

EZETIMIBE 163222-33-1 INTERMEDIATES

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline ISO 9001：2015 REACH

4-(4-Benzyloxybenzlidipine)-P-Fluoro Aniline

1H-Indene-1,3(2H)-dione,5,11-dichloro-

Propanoylchloride,5-ethoxy-

4'-(Benzyloxy)benzylidene-4-fluoroaniline, ≥ 98.0%

4'-(Benzyloxy)benzylidene-4-fluoroaniline

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline (Intermediate of Ezetimibe)

4-Fluoro-N-[[4-(benzyloxy)phenyl]methylene]-aniline

70627-52-0

C20H16FNO