ChemicalBook > CAS DataBase List > N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

Product Name
N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline
CAS No.
70627-52-0
Chemical Name
N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline
Synonyms
ETMB-02;Ezetimibe Impurity 80;Propanoylchloride,5-ethoxy-;4-Benzyloxybenzylidene-(4-f...;EZETIMIBE 163222-33-1 INTERMEDIATES;1H-Indene-1,3(2H)-dione,5,11-dichloro-;4-(4-Benzyloxybenzylidene)Fluoroaniline;4-BENZYLOXYBENZYLIDENE-(4-FLUORO)ANILINE;4'-(Benzyloxy)benzylidene-4-fluoroaniline;4, 4-Benzyloxybenzylidene P- Fluoroaniline
CBNumber
CB2363060
Molecular Formula
C20H16FNO
Formula Weight
305.35
MOL File
70627-52-0.mol
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N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Property

Melting point:
136-138 ºC
Boiling point:
455.2±35.0 °C(Predicted)
Density 
1.07
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Acetonitrile (Slightly), Chlorofrom (Slightly), Methanol (Slightly, Sonicated)
form 
Solid
pka
3.71±0.50(Predicted)
color 
Very Dark Orange
InChI
InChI=1S/C20H16FNO/c21-18-8-10-19(11-9-18)22-14-16-6-12-20(13-7-16)23-15-17-4-2-1-3-5-17/h1-14H,15H2
InChIKey
IWNBEFDVKWCBFY-UHFFFAOYSA-N
SMILES
C1(N=CC2=CC=C(OCC3=CC=CC=C3)C=C2)=CC=C(F)C=C1
CAS DataBase Reference
70627-52-0
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Safety

HS Code 
2925.29.9000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B4301
Product name
4'-(Benzyloxy)benzylidene-4-fluoroaniline
Purity
>98.0%(GC)
Packaging
5g
Price
$38
Updated
2025/07/31
TCI Chemical
Product number
B4301
Product name
4'-(Benzyloxy)benzylidene-4-fluoroaniline
Purity
>98.0%(GC)
Packaging
25g
Price
$192
Updated
2025/07/31
TRC
Product number
B286525
Product name
4-Benzyloxybenzylidene4-Fluoroaniline
Packaging
100mg
Price
$150
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0012856
Product name
4-BENZYLOXYBENZYLIDENE-(4-FLUORO)ANILINE
Purity
95.00%
Packaging
1G
Price
$1380.23
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
43706
Product name
4-Benzyloxybenzylidene4-Fluoroaniline
Packaging
1g
Price
$2200
Updated
2021/12/16
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N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Chemical Properties,Usage,Production

Uses

4-Benzyloxybenzylidene 4-Fluoroaniline is an intermediate in the synthesis of Linezolid (L466500).

Synthesis

4397-53-9

371-40-4

70627-52-0

General procedure for the synthesis of 4-benzylbenzylidene-(4-fluoro)aniline from 4-benzyloxybenzaldehyde and 4-fluorobenzenamine: 4-fluorobenzylidene-(4-fluoro)aniline (100 g, 1.1 eq.) was mixed with isopropanol (1730 ml, 10 V) and heated under mechanical stirring up to 40 °C, whereby a large amount of light yellow crystalline solid was gradually precipitated. Stirring was continued and the reaction was monitored until completion. The heating was stopped and the reaction was cooled naturally to room temperature with stirring. Extraction and filtration operations were carried out, and the filter cake was washed with cold isopropanol and dried to give the light yellow crystalline product SM 2 with a mass of 238 g, 95% yield and 99% purity.

References

[1] Patent: JP2016/147843, 2016, A. Location in patent: Paragraph 0016
[2] Patent: CN107793339, 2018, A. Location in patent: Paragraph 0021; 0023; 0031; 0038
[3] Pharmacy and Pharmacology Communications, 2000, vol. 6, # 1, p. 25 - 29
[4] Journal of Organic Chemistry, 2018,

N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Preparation Products And Raw materials

Raw materials

Ethanol N,N-Dimethylformamide Potassium iodide Sodium sulfate Potassium carbonate PETROLEUM ETHER 4-Hydroxybenzaldehyde Benzyl bromide Ethyl acetate 4-Fluoroaniline

Preparation Products

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View Lastest Price from N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
4-BENZYLOXYBENZYLIDENE-(4-FLUORO)ANILINE 70627-52-0
Price
US $2.00-5.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-07-24
Henan Aochuang Chemical Co.,Ltd.
Product
N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline 70627-52-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Shanghai CRM New Material Technology Co., LTD
Product
N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline 70627-52-0
Price
US $10.00-15.00/g
Min. Order
10g
Purity
99%
Supply Ability
2546245
Release date
2022-11-10

70627-52-0, N-(4-(Benzyloxy)benzylidene)-4-fluoroanilineRelated Search:

(3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one Benzyloxyacetyl chloride 4-Fluoroaniline 3,3',5,5'-Tetramethylbenzidine dihydrochloride PHENYL VALERATE Phenetidine p-Anisidine 4-Methoxybenzyl alcohol N,N-Dimethylaniline 4-(Trifluoromethoxy)aniline Benzalacetone Methyltrimethoxysilane 4-Methoxybenzylchloride Phenylhydrazine 4-[[(4-Fluorophenyl)imino]methyl]-phenol 4,4'-Diphenylmethane diisocyanate Methylene Blue 5-(4-FLUOROPHENYL)VALERIC ACID

  • 4-BENZYLOXYBENZYLIDENE-(4-FLUORO)ANILINE
  • 4-(4-Benzyloxybenzylidene)Fluoroaniline
  • N-(4-(benzyloxy)benzylidene)-4-fluorobenzenamine
  • 4-Fluoro-N-[[4-(phenylmethoxy)phenyl]methylene]benzenamine
  • N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline
  • 4, 4-Benzyloxybenzylidene P- Fluoroaniline
  • 4-Benzyloxybenzylidene-(4-f...
  • BenzenaMine,4-fluoro-N-[[4-(phenylMethoxy)phenyl]Methylene]-
  • ETMB-02
  • N-(4-fluorophenyl)-1-(4-phenylmethoxyphenyl)methanimine
  • N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline70627-52-0
  • Ezetimibe Impurity 80
  • N-fluoro-4-[(4-phenylmethoxyphenyl)methylidene]-1-cyclohexa-1,5-dienamine
  • 4'-(Benzyloxy)benzylidene-4-fluoroaniline &gt
  • EZETIMIBE 163222-33-1 INTERMEDIATES
  • N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline ISO 9001：2015 REACH
  • 4-(4-Benzyloxybenzlidipine)-P-Fluoro Aniline
  • 1H-Indene-1,3(2H)-dione,5,11-dichloro-
  • Propanoylchloride,5-ethoxy-
  • 4'-(Benzyloxy)benzylidene-4-fluoroaniline, ≥ 98.0%
  • 4'-(Benzyloxy)benzylidene-4-fluoroaniline
  • N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline (Intermediate of Ezetimibe)
  • 4-Fluoro-N-[[4-(benzyloxy)phenyl]methylene]-aniline
  • 70627-52-0
  • C20H16FNO