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p-Anisidine

Product Name
p-Anisidine
CAS No.
104-94-9
Chemical Name
p-Anisidine
Synonyms
nsc7921;ccris917;ai3-02392;4-Anisidin;P-ANISIDINE;4-ANISIDINE;1,4-Anisidine;p-Anisylamine;4-Anisidine 0;For anisidine
CBNumber
CB6852649
Molecular Formula
C7H9NO
Formula Weight
123.15
MOL File
104-94-9.mol
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p-Anisidine Property

Melting point:
56-59 °C(lit.)
Boiling point:
240-243 °C(lit.)
Density 
1.06
vapor density 
4.28
vapor pressure 
0.02 hPa (20 °C)
refractive index 
1.5559
Flash point:
122 °C
storage temp. 
Store below +30°C.
solubility 
21g/l
pka
5.34(at 25℃)
form 
crystalline
Specific Gravity
1.07
color 
dark gray to brown
PH
7.7 (1g/l, H2O, 20℃)
Water Solubility 
21 g/L (20 ºC)
Merck 
14,667
BRN 
471556
Henry's Law Constant
(x 10-8 atm?m3/mol): 6.62 at 25 °C (thermodynamic method-GC/UV spectrophotometry, Altschuh et al., 1999)
Exposure limits
NIOSH REL: TWA 0.5 mg/m3, IDLH 50 mg/m3; OSHA PEL: TWA 0.5 mg/m3; ACGIH TLV: TWA 0.1 ppm (adopted).
CAS DataBase Reference
104-94-9(CAS DataBase Reference)
IARC
3 (Vol. 27, Sup 7) 1987
NIST Chemistry Reference
Benzenamine, 4-methoxy-(104-94-9)
EPA Substance Registry System
p-Anisidine (104-94-9)
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Safety

Hazard Codes 
T+,N,Xi
Risk Statements 
45-26/27/28-33-50
Safety Statements 
53-28-36/37-45-61-28A
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
2
RTECS 
BZ5450000
8
Autoignition Temperature
959 °F
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29222200
Hazardous Substances Data
104-94-9(Hazardous Substances Data)
Toxicity
Acute oral LD50 for rats 1,400 mg/kg, mice 810 mg/kg, rabbits 2,900 mg/kg (quoted, RTECS, 1985).
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H301Toxic if swalloed

H310Fatal in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H330Fatal if inhaled

H350May cause cancer

H370Causes damage to organs

H372Causes damage to organs through prolonged or repeated exposure

H373May cause damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P320Specific treatment is urgent (see … on this label).

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P405Store locked up.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.00458
Product name
p-Anisidine
Purity
for synthesis
Packaging
100 g
Price
$27.47
Updated
2021/03/22
Sigma-Aldrich
Product number
A88255
Product name
p-Anisidine
Purity
≥99%
Packaging
5g
Price
$18.2
Updated
2021/03/22
Sigma-Aldrich
Product number
8.00458
Product name
p-Anisidine
Purity
for synthesis
Packaging
500 g
Price
$70.85
Updated
2021/03/22
Sigma-Aldrich
Product number
A88255
Product name
p-Anisidine
Purity
≥99%
Packaging
1kg
Price
$128
Updated
2021/03/22
TCI Chemical
Product number
A0487
Product name
p-Anisidine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$27
Updated
2021/03/22
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p-Anisidine Chemical Properties,Usage,Production

Chemical Properties

Anisidine exists as ortho-, meta-, and paraisomers. They have characteristic amine (fishy) odors.

Chemical Properties

grey to brown crystalline powder, granules

Physical properties

Yellow to light brown powder, leaflets, solid or crystals with a characteristic amine or ammonialike odor

Uses

p-Anisidine is used mostly for producing dyes, and some smaller quantities are employed in making pharmaceuticals and liquid crystals.

Uses

p-Anisidine is used as a reagent to indicate the secondary stage of the oxidation, it is one of the three possible isomers of the Anisidine or methoxyaniline. The other two isomers are o-Anisidine (2-methoxyaniline) and m-Anisidine (3-methoxyaniline).
The p-anisidine is widely used as an intermediate in the production of numerous azo and triphenylmethane dyes, and pigments. It is also used in the production of pharmaceuticals including the guaiacol expectorant, as an antioxidant for polymercaptan resins, and as a corrosion inhibitor for steel. Apart from the beneficial use of p-anisidine, it is toxic for human beings. The acute exposure may cause skin irritation, whereas the chronic exposure may cause headaches, vertigo, and blood complications like sulfhemoglobin, and methemoglobin. The oral exposure to anisidine hydrochloride resulted in cancer of the urinary bladder in male and female rats.
https://www.longdom.org/open-access/physicochemical-and-spectroscopic-characterization-of-biofield-energytreated-panisidine-paco-1000102.pdf

Uses

In the preparation of azo dyes; corrosion inhibitor; chemical intermediate

Synthesis Reference(s)

Journal of the American Chemical Society, 99, p. 98, 1977 DOI: 10.1021/ja00443a018
The Journal of Organic Chemistry, 49, p. 1434, 1984 DOI: 10.1021/jo00182a023
Tetrahedron Letters, 21, p. 2603, 1980 DOI: 10.1016/S0040-4039(00)92816-8

General Description

Brown crystals or dark brown solid. Characteristic amine odor.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

p-Anisidine may be sensitive to heat, light and moisture. Reacts with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents. Incompatible with alkaline materials. Incompatible with aldehydes, ketones and nitrates.

Hazard

Strong irritant. Toxic when absorbed through the skin. Questionable carcinogen.

Fire Hazard

p-Anisidine is flammable.

Safety Profile

Moderately toxic by several routes. A mild sensitizer. May cause a contact dermatitis. Mutation data reported. Questionable carcinogen. See also ANILINE. When heated to decomposition it emits toxic fumes of Nox

Potential Exposure

Anisidines are used in the manufacture of azo dyes; pharmaceuticals; textile-processing chemicals Incompatibilities: Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine,bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Attacks some coatings and some forms of plastic and rubber.

Carcinogenicity

Available data were inadequate to evaluate the carcinogenicity of p-anisidine.

Environmental Fate

Chemical/Physical. Releases toxic nitrogen oxides when heated to decomposition (Sax and Lewis, 1987).

Shipping

UN2431 Anisidines, Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Purification Methods

Crystallise p-anisidine from H2O or aqueous EtOH. Dry it in a vacuum oven at 35o for 6hours and store it in a dry box. [More et al. J Am Chem Soc 108 2257 1986.] Purify it also by vacuum sublimation [Guarr et al. J Am Chem Soc 107 5104 1985]. [Beilstein 13 IV 1015.]

Waste Disposal

Dissolve in combustible solvent (alcohols, benzene, etc.) and spray solution into furnace equipped with afterburner and scrubber, or burn spill residue on sand and soda ash absorbent in a furnace.

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p-Anisidine Suppliers

GuangTuo Chemical (Shanghai) Co., Ltd.
Tel
021-60899189-8001 18918189673
Fax
021-60899304
Email
gtchem@126.com
Country
China
ProdList
2673
Advantage
58
Changzhou GuangJia Chemical Co. Ltd.
Tel
0519-85267898-
Fax
0519-85267898
Email
sales@guanjiachem.net;
Country
China
ProdList
17
Advantage
55
Shanghai Kaisai Chemical Co., Ltd
Tel
021-33516711;021-33516722
Fax
021-33516776
Email
kaisaichem1@163.com;kaisaichem1@163.com
Country
China
ProdList
4719
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2346
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
010-60275820-
Fax
010-60270825
Email
elainezt@sina.com
Country
China
ProdList
1401
Advantage
62
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43496
Advantage
61
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View Lastest Price from p-Anisidine manufacturers

Hebei Guanlang Biotechnology Co., Ltd.
Product
p-Anisidine 104-94-9
Price
US $10.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2021-05-12
Hebei Miaobian Biotechnology Co., Ltd
Product
p-Anisidine 104-94-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99.99
Supply Ability
10Ton
Release date
2020-11-27
Shaanxi Dideu Medichem Co. Ltd
Product
p-Anisidine 104-94-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-01-02

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