4-Nitroanisole
- Product Name
- 4-Nitroanisole
- CAS No.
- 100-17-4
- Chemical Name
- 4-Nitroanisole
- Synonyms
- 1-METHOXY-4-NITROBENZENE;Nitroanisole;4-Nitroanisol;PARA-NITROANISOLE;4-Nitroanisole,98%;p-Nitroanisol;p-nitro-anisol;4-NITROANISOLE;P-NITROANISOLE;Anisole, p-nitro-
- CBNumber
- CB0182966
- Molecular Formula
- C7H7NO3
- Formula Weight
- 153.14
- MOL File
- 100-17-4.mol
4-Nitroanisole Property
- Melting point:
- 51-53 °C
- Boiling point:
- 260 °C
- Density
- 1.233 g/mL at 25 °C(lit.)
- refractive index
- 1.5030 (estimate)
- Flash point:
- 130 °C
- form
- Crystals
- Specific Gravity
- 1.233
- color
- Green to brown
- Water Solubility
- 0.468 g/L (20 ºC)
- Merck
- 14,6584
- BRN
- 1865361
- Dielectric constant
- 24.0(20℃)
- Stability:
- Stable. Incompatible with strong oxidizing agents, strong bases.
- CAS DataBase Reference
- 100-17-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzene, 1-methoxy-4-nitro-(100-17-4)
- IARC
- 2B (Vol. 123) 2020
- EPA Substance Registry System
- p-Nitroanisole (100-17-4)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H351Suspected of causing cancer
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 103543
- Product name
- 4-Nitroanisole
- Purity
- 97%
- Packaging
- 5g
- Price
- $31.3
- Updated
- 2023/06/20
- Product number
- 103543
- Product name
- 4-Nitroanisole
- Purity
- 97%
- Packaging
- 25g
- Price
- $55.2
- Updated
- 2023/06/20
- Product number
- N0126
- Product name
- 4-Nitroanisole
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $23
- Updated
- 2023/06/20
- Product number
- N0126
- Product name
- 4-Nitroanisole
- Purity
- >98.0%(GC)
- Packaging
- 100g
- Price
- $48
- Updated
- 2023/06/20
- Product number
- A19152
- Product name
- 4-Nitroanisole, 97%
- Packaging
- 250g
- Price
- $36.7
- Updated
- 2023/06/20
4-Nitroanisole Chemical Properties,Usage,Production
Chemical Properties
beige crystalline solid. soluble in alcohol, ether and boiling petroleum ether, slightly soluble in cold petroleum ether, insoluble in water.
Uses
o-Isomer as dye intermediate; in organic syntheses.
Uses
4-Nitroanisole is an intermediate in the manufacture of azo dyes. A toxic organic pollutant and a risk factor for urinary bladder cancer in humans.
Definition
ChEBI: 4-nitroanisole is a member of the class of 4-nitroanisoles that is anisole in which one the hydrogen meta to the methoxy group is replaced by a nitro group.
Preparation
Produced from p-nitrochlorobenzene by methoxylation.
Synthesis Reference(s)
Synthetic Communications, 25, p. 1367, 1995 DOI: 10.1080/00397919508013838
Tetrahedron Letters, 14, p. 1397, 1973
General Description
A light red or amber-colored liquid or crystals. Insoluble in water and denser than water. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion, inhalation or skin absorption. Used to make other chemicals.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
4-Nitroanisole reacts explosively with (sodium hydroxide + zinc). 4-Nitroanisole reacts vigorously with hydrogen + catalyst (at 482° F and 25500 mm Hg).
Health Hazard
Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Biochem/physiol Actions
4-Nitroanisole is O-demethylated to 4-nitrophenol by human liver microsomes.
Safety Profile
A poison by ingestion. Mutation data reported. Can explode in presence of Ni. When heated to decomposition it emits toxic fumes of NOx. See also o-NITROANISOLE and NITRO COMPOUNDS OF AROMATIC HYDROCARBONS.
Purification Methods
Crystallise it from pet ether or hexane and dry it in vacuo. [Beilstein 6 IV 1282.]
4-Nitroanisole Preparation Products And Raw materials
Raw materials
Preparation Products
4-Nitroanisole Suppliers
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